Early Family Prevention of Adolescent Alcohol, Drug Use and Psychopathology

青少年酗酒、吸毒和精神病理学的早期家庭预防

• 批准号: 9269169
• 负责人: THOMAS J. DISHION
• 金额: $ 132.99万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9269169
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent; Age; Alcohol consumption; Alcohol or Other Drugs use; Behavior; Child; Child Rearing; Childhood; Clinical; Coercion; Collection; Communities; Cost Effectiveness Analysis; DNA; Data; Drug usage; Ecology; Education; Effectiveness; Eligibility Determination; Environment; Ethnic Origin; Family; Future; Genes; Genetic; Genetic Risk; Geography; HIV; Income; Intention; Intervention; Lifestyle-related condition; Link; Long-Term Effects; Longitudinal Studies; Low income; Mediating; Mediation; Mediator of activation protein; Methods; Modeling; Neighborhoods; Outcome; Parent-Child Relations; Parents; Participant; Pathway interactions; Prevention; Prevention trial; Preventive; Problem behavior; Psychopathology; Public Health; Randomized; Recruitment Activity; Reporting; Resources; Rewards; Risk; Risk Factors; Rural Community; Sampling; Schools; Services; Site; Testing; Time; Toddler; Youth; adolescent alcohol; adolescent substance use; alcohol risk; base; checkup examination; conduct problem; deprivation; design; deviant; early adolescence; early childhood; ethnic diversity; executive function; experience; family management; family support; follow up assessment; follow-up; gene environment interaction; high risk; high risk sexual behavior; improved; intervention effect; maternal stress; parental monitoring; peer; public health relevance; reduce adolescent alcohol; social; social exclusion; socioeconomics; substance use prevention; suburban communities; teacher

DESCRIPTION (provided by applicant): This proposal will test the long-term impact of the Family Check-Up (FCU) approach to preventing substance use and other high-risk problem behaviors from toddlerhood through adolescence by enhancing parenting. A critical question for a randomized prevention trial such as this is the extent to which early family support reduces adolescent alcohol and drug use (ADU), high-risk sexual behavior linked to HIV-AIDS, and serious problem behaviors in adolescence. The study also will examine how reduction in these adolescent problem behaviors is mediated by improvement in parenting and peer environments and is moderated by the family ecology and genetic risk. The proposed study will include follow-up assessments of 731 children through adolescence that include the collection of DNA; observations of family interaction; parent, youth and teacher report of adjustment; and assessments of and reports about peer environments. The Early Steps (ES) multisite sample was recruited from WIC centers in three geographically, socioeconomically, and ethnically diverse communities: Pittsburgh, PA; Charlottesville, VA; and Eugene, OR. To increase the number of sample families at risk for later ADU, eligibility was restricted to WIC families with additional socioeconomic (i.e., low parental education), family (i.e., maternal stress), and child (i.e., toddler conduct problems) risk factors. The children and families were initially assessed at child age 2 and then yearly through age 10.5, using a multi-agent and multi-method strategy that included direct observations of family interaction in most years. Families were randomly assigned to be offered a yearly FCU intervention, including adapted and tailored family management interventions. Specifically, the Family Check-Up will be evaluated as it relates to reducing adolescent substance use, high-risk sexual behavior linked to HIV, and other serious problem behavior at ages 14 and 16, how such intervention effects might be mediated by changes in parenting, and moderated by neighborhood adversity and GxE interactions.

描述（由申请人提供）：本提案将测试家庭检查（FCU）方法的长期影响，通过加强父母的教育，防止从幼儿期到青春期的药物使用和其他高风险问题行为。像这样的随机预防试验的一个关键问题是，早期家庭支持在多大程度上减少了青少年酗酒和吸毒（ADU）、与艾滋病毒/艾滋病相关的高风险性行为以及青春期的严重问题行为。该研究还将研究这些青少年问题行为的减少是如何通过父母教养和同伴环境的改善来调节的，并受到家庭生态和遗传风险的调节。这项拟议的研究将包括对731名儿童的后续评估，包括收集DNA；家庭互动观察；家长、青少年及老师的调整报告；以及对同伴环境的评估和报告。早期步骤（ES）多站点样本从三个地理、社会经济和种族多样化社区的WIC中心招募：宾夕法尼亚州匹兹堡；弗吉尼亚州夏洛茨维尔;和俄勒冈州的尤金。为了增加后期ADU风险的样本家庭数量，资格仅限于具有额外的社会经济（即父母教育程度低），家庭（即母亲压力）和儿童（即幼儿行为问题）风险因素的WIC家庭。儿童和家庭最初接受了评估