Early Family Prevention of Adolescent Alcohol, Drug Use and Psychopathology - Research Supplements to Promote Diversity in Health Related Research Supplement

青少年酒精、吸毒和精神病理学的早期家庭预防 - 促进健康相关研究补充多样性的研究补充

• 批准号: 9408847
• 负责人: THOMAS J. DISHION
• 金额: $ 12.87万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9408847
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescence; Adolescent; Age; Alcohol consumption; Alcohol or Other Drugs use; Behavior; Child; Child Rearing; Childhood; Clinical; Coercion; Collection; Communities; Cost Effectiveness Analysis; DNA; Data; Drug usage; Ecology; Education; Effectiveness; Eligibility Determination; Environment; Ethnic Origin; Family; Future; Genes; Genetic; Genetic Risk; Geography; HIV; Health; Income; Intention; Intervention; Lifestyle-related condition; Link; Long-Term Effects; Longitudinal Studies; Low income; Mediating; Mediation; Mediator of activation protein; Methods; Modeling; Neighborhoods; Outcome; Parent-Child Relations; Parents; Participant; Pathway interactions; Prevention; Prevention trial; Preventive; Problem behavior; Psychopathology; Public Health; Randomized; Recruitment Activity; Reporting; Research; Resources; Rewards; Risk; Risk Factors; Rural Community; Sampling; Schools; Services; Site; Testing; Time; Toddler; Youth; adolescent alcohol; adolescent substance use; alcohol risk; base; checkup examination; conduct problem; deprivation; design; deviant; early adolescence; early childhood; ethnic diversity; executive function; experience; family management; family support; follow up assessment; follow-up; gene environment interaction; high risk; high risk sexual behavior; improved; intervention effect; maternal stress; parental monitoring; peer; public health relevance; reduce adolescent alcohol; social; social exclusion; socioeconomics; substance use prevention; suburban communities; teacher

DESCRIPTION (provided by applicant): This proposal will test the long-term impact of the Family Check-Up (FCU) approach to preventing substance use and other high-risk problem behaviors from toddlerhood through adolescence by enhancing parenting. A critical question for a randomized prevention trial such as this is the extent to which early family support reduces adolescent alcohol and drug use (ADU), high-risk sexual behavior linked to HIV-AIDS, and serious problem behaviors in adolescence. The study also will examine how reduction in these adolescent problem behaviors is mediated by improvement in parenting and peer environments and is moderated by the family ecology and genetic risk. The proposed study will include follow-up assessments of 731 children through adolescence that include the collection of DNA; observations of family interaction; parent, youth and teacher report of adjustment; and assessments of and reports about peer environments. The Early Steps (ES) multisite sample was recruited from WIC centers in three geographically, socioeconomically, and ethnically diverse communities: Pittsburgh, PA; Charlottesville, VA; and Eugene, OR. To increase the number of sample families at risk for later ADU, eligibility was restricted to WIC families with additional socioeconomic (i.e., low parental education), family (i.e., maternal stress), and child (i.e., toddler conduct problems) risk factors. The children and families were initially assessed at child age 2 and then yearly through age 10.5, using a multi-agent and multi-method strategy that included direct observations of family interaction in most years. Families were randomly assigned to be offered a yearly FCU intervention, including adapted and tailored family management interventions. Specifically, the Family Check-Up will be evaluated as it relates to reducing adolescent substance use, high-risk sexual behavior linked to HIV, and other serious problem behavior at ages 14 and 16, how such intervention effects might be mediated by changes in parenting, and moderated by neighborhood adversity and GxE interactions.

描述（由申请人提供）：本提案将测试家庭检查（FCU）方法的长期影响，以通过加强养育来预防从幼儿期到青春期的药物使用和其他高风险问题行为。像这样的随机预防试验的一个关键问题是早期家庭支持在多大程度上减少了青少年酒精和药物使用（ADU），与艾滋病毒/艾滋病相关的高风险性行为以及青少年的严重问题行为。该研究还将研究如何减少这些青少年问题行为是通过改善父母和同伴环境来介导的，并受到家庭生态和遗传风险的调节。拟议的研究将包括对731名儿童到青春期的后续评估，其中包括收集DNA;观察家庭互动;父母、青年和教师的适应报告;以及对同伴环境的评估和报告。早期步骤（ES）多地点样本从WIC中心在三个地理，社会经济和种族多样化的社区：匹兹堡，宾夕法尼亚州，夏洛茨维尔，弗吉尼亚州和尤金，OR。为了增加后期面临ADU风险的样本家庭数量，资格仅限于具有额外社会经济地位的WIC家庭（即，父母教育程度低），家庭（即，母亲压力），和儿童（即，幼儿行为问题）的危险因素。这些儿童和家庭最初被评估为 儿童年龄2岁，然后每年通过年龄10.5，使用多代理和多方法的战略，其中包括在大多数年份的家庭互动的直接观察。家庭被随机分配，每年提供FCU干预，包括调整和定制的家庭管理干预。具体来说，家庭检查将进行评估，因为它涉及到减少青少年物质使用，与艾滋病毒相关的高风险性行为，以及14岁和16岁的其他严重问题行为，这种干预效果如何通过父母的改变来介导，并通过邻里逆境和GxE相互作用来调节。