Effects of cigar flavors on measures of abuse liability among young adults

雪茄口味对年轻人滥用倾向的影响

• 批准号: 9350274
• 负责人: Andrew James Barnes
• 金额: $ 11.44万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9350274
• 关键词: Address; Adult; Apple; Behavioral; Candy; Cessation of life; Characteristics; Cigar; Cigar Smoking; Cigarette; Cigarette Smoker; Consumption; Cream; Dependence; Epidemiology; Exposure to; Formulation; Fruit; Grant; Guidelines; High School Student; Individual; Laboratories; Lead; Link; Marketing; Masks; Measures; Menthol; Methods; Nicotine; Perception; Physical Dependence; Physiological; Policies; Population; Procedures; Psychological Dependence; Psychotropic Drugs; Public Health; Regulation; Reporting; Research; Risk; Sales; Saliva; Smoke; Smoker; Taste Perception; Taxes; Testing; Time; Tobacco; Tobacco Industry; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; Weight; Wine; Work; Youth; aged; authority; behavior measurement; ethnic minority population; evidence base; high risk; innovation; nonmedical use; racial and ethnic; smoke inhalation; young adult

PROJECT SUMMARY Tobacco use contributes to nearly half a million deaths in the United States annually. To reduce this death toll, the Food and Drug Administration (FDA) was granted regulatory authority over tobacco in 2009. This authority was limited with respect to cigars, which are increasingly popular. In 2014, FDA proposed broader regulatory control over these products, including flavored cigars. The availability of cigar flavors, among other characteristics, has been linked to increased sales and consumption, with the largest increases among youth/young adults and certain racial/ethnic minorities. No studies exist quantifying the effect of cigar flavors on abuse liability—the degree to which a psychoactive drug or formulation would be used for nonmedical purposes and that abuse would lead to dependence. Such evidence is essential to reducing cigar smoking among youth/young adults, who have a high risk of experimentation and relevance to FDA priorities. The current study aims to address this critical evidence gap by systematically examining the effect of four flavors of Black & Mild (B&M), the most popular cigar brand, on three measures of abuse liability in young adult conventional tobacco cigarette (CTC) smokers: 1) exposure to nicotine via saliva concentrations; 2) breakpoint from behavioral tasks where individuals choose between money or cigar puffs; 3) and subjective measures of cigar effects. Current CTC smokers (N=25; aged 18-21 years), who are inexperienced cigar smokers (≤5 times), will complete 5 Latin-square ordered, within-subject laboratory conditions that differ by product smoked: own brand CTC or B&M cigars in original, apple, cream, or wine flavor. The proposed study closely aligns with FDA-CTP priorities articulated in RFA-OD-15-004 including cigar initiation, use (and multiple use), perceptions, dependence and toxicity and the impact of tobacco product characteristics on initiation among populations most at-risk for flavored tobacco use. Results from this work will inform the impending regulation of cigars specifically as well as provide a method that can be used to evaluate the influence of flavors in other tobacco products. We will leverage the evidence base established from this research into a R01 proposal to test a broad spectrum of policies to regulate tobacco product flavors.

项目摘要 在美国，吸烟每年导致近50万人死亡。减少 这一死亡人数，食品和药物管理局（FDA）被授予监管权力， 2009年，烟草。这一权力在雪茄方面受到限制，雪茄越来越受欢迎。 2014年，FDA提议对这些产品进行更广泛的监管控制，包括调味雪茄。 雪茄口味的可用性，以及其他特性，与销售增加有关 青年/年轻人和某些种族/族裔群体的增幅最大， 少数群体 目前还没有研究量化雪茄口味对滥用倾向的影响-- 精神活性药物或制剂将用于非医疗目的，滥用将导致 依赖这些证据对于减少年轻人/年轻人吸烟至关重要，他们 实验的高风险和与FDA优先事项的相关性。 目前的研究旨在通过系统地检查这种影响来解决这一关键证据缺口。 最受欢迎的雪茄品牌Black & Mild（B&M）的四种口味的三种滥用程度 年轻成年传统烟草香烟（CTC）吸烟者的易感性：1）通过 唾液浓度; 2）行为任务的断点，其中个体在金钱之间进行选择 或雪茄泡芙; 3）和雪茄效果的主观测量。当前CTC吸烟者（N=25;年龄18-21岁 年），谁是没有经验的雪茄吸烟者（≤5次），将完成5拉丁方订购， 受试者内实验室条件因吸烟产品而异： 原味、苹果味、奶油味或葡萄酒味。 拟议研究与RFA-OD-15-004中阐述的FDA-CTP优先事项密切一致，包括 雪茄的开始，使用（和多次使用），感知，依赖性和毒性以及 在最易食用香料烟草的人群中， 使用.这项工作的结果将具体告知即将实施的雪茄法规， 提供了一种可用于评估其他烟草产品中香料影响的方法。 我们将利用从本研究中建立的证据基础，将其纳入R 01提案，以测试 广泛的政策来规范烟草产品的口味。