Effects of cigar flavors on measures of abuse liability among young adults

雪茄口味对年轻人滥用倾向的影响

• 批准号: 9350274
• 负责人: Andrew James Barnes
• 金额: $ 11.44万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9350274
• 关键词: Address; Adult; Apple; Behavioral; Candy; Cessation of life; Characteristics; Cigar; Cigar Smoking; Cigarette; Cigarette Smoker; Consumption; Cream; Dependence; Epidemiology; Exposure to; Formulation; Fruit; Grant; Guidelines; High School Student; Individual; Laboratories; Lead; Link; Marketing; Masks; Measures; Menthol; Methods; Nicotine; Perception; Physical Dependence; Physiological; Policies; Population; Procedures; Psychological Dependence; Psychotropic Drugs; Public Health; Regulation; Reporting; Research; Risk; Sales; Saliva; Smoke; Smoker; Taste Perception; Taxes; Testing; Time; Tobacco; Tobacco Industry; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; Weight; Wine; Work; Youth; aged; authority; behavior measurement; ethnic minority population; evidence base; high risk; innovation; nonmedical use; racial and ethnic; smoke inhalation; young adult

PROJECT SUMMARY Tobacco use contributes to nearly half a million deaths in the United States annually. To reduce this death toll, the Food and Drug Administration (FDA) was granted regulatory authority over tobacco in 2009. This authority was limited with respect to cigars, which are increasingly popular. In 2014, FDA proposed broader regulatory control over these products, including flavored cigars. The availability of cigar flavors, among other characteristics, has been linked to increased sales and consumption, with the largest increases among youth/young adults and certain racial/ethnic minorities. No studies exist quantifying the effect of cigar flavors on abuse liability—the degree to which a psychoactive drug or formulation would be used for nonmedical purposes and that abuse would lead to dependence. Such evidence is essential to reducing cigar smoking among youth/young adults, who have a high risk of experimentation and relevance to FDA priorities. The current study aims to address this critical evidence gap by systematically examining the effect of four flavors of Black & Mild (B&M), the most popular cigar brand, on three measures of abuse liability in young adult conventional tobacco cigarette (CTC) smokers: 1) exposure to nicotine via saliva concentrations; 2) breakpoint from behavioral tasks where individuals choose between money or cigar puffs; 3) and subjective measures of cigar effects. Current CTC smokers (N=25; aged 18-21 years), who are inexperienced cigar smokers (≤5 times), will complete 5 Latin-square ordered, within-subject laboratory conditions that differ by product smoked: own brand CTC or B&M cigars in original, apple, cream, or wine flavor. The proposed study closely aligns with FDA-CTP priorities articulated in RFA-OD-15-004 including cigar initiation, use (and multiple use), perceptions, dependence and toxicity and the impact of tobacco product characteristics on initiation among populations most at-risk for flavored tobacco use. Results from this work will inform the impending regulation of cigars specifically as well as provide a method that can be used to evaluate the influence of flavors in other tobacco products. We will leverage the evidence base established from this research into a R01 proposal to test a broad spectrum of policies to regulate tobacco product flavors.

项目摘要 在美国年度，烟草的使用造成了近半百万的死亡。减少 这次死亡人数，食品和药物管理局（FDA）被授予监管机构 2009年的烟草。关于公民越来越受欢迎的民事，这种权威受到限制。 2014年，FDA提出了对这些产品的更广泛的监管控制，包括调味的公民。 雪茄口味的可用性以及其他特征与销售的增加有关 和消费，青年/年轻人的增长最大，某些种族/种族 少数民族。 尚无研究来量化雪茄口味对滥用责任的影响 - 精神活性药物或配方将用于非医学目的，滥用将导致 依赖。这种证据对于减少有雪茄吸烟至关重要 实验的高风险和与FDA优先级相关的风险。 当前的研究旨在通过系统地检查效果来解决这一关键证据差距 最受欢迎的雪茄品牌的黑白（B＆M）的四种口味，以三种虐待措施 年轻成人常规烟草香烟（CTC）吸烟者的责任：1）通过 唾液浓度； 2）从个人在金钱之间选择的行为任务中的断点 或雪茄泡芙； 3）和雪茄效应的主观度量。当前的CTC吸烟者（n = 25；年龄18-21岁 几年），没有经验的雪茄吸烟者（≤5次），将完成5个拉丁平方订购， 受试者的受试者内实验室条件因吸烟而不同：自己的品牌CTC或B＆M民用 原始，苹果，奶油或葡萄酒味。 拟议的研究与在RFA-OD-15-004中阐明的FDA-CTP的优先级紧密一致 雪茄倡议，使用（和多种用途），感知，依赖性和毒性以及影响 烟草产品特征关于种群中最高风险的烟草的烟草的特征 使用。这项工作的结果将为即将到来的民用法规以及 提供一种可用于评估其他烟草产品影响的方法。 我们将利用从这项研究确定的证据基础到R01提案，以测试 广泛的政策，以调节烟草产品口味。