Predicting Effects of ENDS Flavor Regulations Among Latinx/e Smokers: Impact of Cultural Assets on Attitudes, Intentions, and Behavior.

项目总结。吸烟是肺癌的主要诱因，肺癌是肺癌的主要诱因。 拉美裔男性癌症死亡原因(13%)，仅次于乳腺癌 女性患癌症(10%)。几乎没有研究过电子尼古丁输送系统是如何 (完)吸烟量影响到拉美吸烟者的烟草使用和相关毒性。最近， FDA开始对JUUL等封闭系统设备进行监管，这些设备已经捕获了超过70%的 终端市场，促进了青年终端使用量的大幅增加。截至2020年初， 加味的端子盒(用作端子的一部分的小的封闭式单元) 薄荷醇/烟草在美国是被禁止的。然而，为了实现其公共卫生使命，FDA 必须在限制接触吸引年轻人的口味与需要证据之间取得平衡 关于某些口味是否以及如何帮助成年吸烟者减少吸烟和 转而使用可能危害较小的产品。了解Ends的潜力，以减少 燃烧烟草使用造成的公共健康负担公平地需要有针对性的研究来预测 未来风味法规将如何影响Latinx/e吸烟者。目前的研究将评估 是否结束香料供应影响烟草使用的衡量标准，并调查 拉丁裔/e成年吸烟者(N=150)成瘾机制的交叉研究 横断面研究。研究人员将专注于弗吉尼亚州服务不足的拉丁裔/e人社区 在需要提供双语服务的地方。这项研究将在文化上 采用来自父母研究的一个目标(预测Ends风味规则对 非裔美国人薄荷醇吸烟者的烟草行为、毒性和滥用倾向)，而 结合交叉文化因素对烟草和物质的可能影响 使用。一系列措施将在一次面对面访问期间以英语或西班牙语实施 在弗吉尼亚州的里士满或通过Zoom。拉丁裔/e社区通常被排除在烟草之外 在卫生服务和药物使用预防方面的研究和服务不足。很多次 可能分享边缘化经验的社区被组织在一起进行研究， 忽略了这些群体之间的关键差异。这项工作的结果将有助于FDA做出 对跨多个交叉的Ends风味限制的监管影响的预测 吸烟者的身份。对这些问题的回答将涉及FDA在行为和 并将提供有关FDA潜在监管后果的新数据 对香料结束的行动有助于最大限度地提高健康效果，并将意外情况降至最低 拉丁裔/e吸烟者的后果。

PROJECT SUMMARY. Smoking is a major contributor to lung cancer, which is the leading cause of cancer death among Latinx/e men (13%) and the second leading cause after breast cancer for women (10%). Little work has examined how electronic nicotine delivery system (ENDS) uptake affects tobacco use and associated toxicity among Latinx/e smokers. Recently, FDA began regulating closed-system devices like JUUL, which have captured over 70% of the ENDS market and contributed to dramatic increases in youth ENDS use. As of early 2020, flavored ENDS cartridges (a small, enclosed unit used as part of an ENDS) other than menthol/tobacco are banned in the US. However, to achieve its public health mission, the FDA must balance restricting access to ENDS flavors that appeal to youth with the need for evidence on “whether and how certain flavors may help adult cigarette smokers reduce cigarette use and switch to potentially less harmful products”. Understanding the potential of ENDS to reduce the public health burden of combusted tobacco use equitably requires a targeted study to predict how future ENDS flavor regulations will impact Latinx/e smokers. The current study will evaluate whether ENDS flavor availability affects measures of tobacco use and investigate the mechanisms of addiction among Latinx/e adult smokers (N=150) by performing a cross- sectional study. The researcher will focus on the underserved Latinx/e community of Virginia where there is a need for the availability of bilingual services. The study will be culturally adapting one aim from the parent study (Predicting effects of ENDS flavor regulations on tobacco behavior, toxicity, and abuse liability among African American menthol smokers) while incorporating the possible implications of intersecting cultural factors on tobacco and substance use. A battery of measures will be administered in English or Spanish during one in person visit in Richmond, Virginia or via Zoom. Latinx/e communities are typically excluded from tobacco research and underserved in health services, and substance use prevention. Many times communities who may share marginalized experiences are grouped together in research which ignores crucial differences between these groups. Results of this work will help the FDA make predictions about the regulatory impact of ENDS flavor restrictions across multiple intersecting identities of smokers. Answers to these questions will address FDA’s priorities in behavior and addiction and will provide new data regarding the consequences of potential FDA regulatory actions on flavor ENDS to help maximize health-promoting effects and minimize unintended consequences among Latinx/e smokers.