Predicting Effects of ENDS Flavor Regulations Among Latinx/e Smokers: Impact of Cultural Assets on Attitudes, Intentions, and Behavior.

项目摘要。吸烟是导致肺癌的主要因素， 拉丁裔/e裔男性癌症死亡的主要原因（13%），是仅次于乳腺癌的第二大原因 女性癌症（10%）。很少有研究表明电子尼古丁输送系统 （ENDS）摄取影响Latinx/e吸烟者的烟草使用和相关毒性。最近， FDA开始监管像JUUL这样的封闭系统设备，这些设备已经捕获了超过70%的 ENDS市场，并促成了青年ENDS使用的急剧增加。截至2020年初， 调味ENDS墨盒（作为ENDS一部分使用的小型封闭单元）， 烟草在美国被禁止。然而，为了实现其公共卫生使命，FDA 必须在限制获得吸引年轻人的ENDS口味与需要证据之间取得平衡 关于“某些口味是否以及如何帮助成年吸烟者减少吸烟， 转向潜在危害较小的产品”。了解ENDS在减少 公平使用燃烧烟草的公共卫生负担需要有针对性的研究来预测 未来的ENDS风味法规将如何影响拉丁裔/e吸烟者。本研究将评价 ENDS香料的可用性是否影响烟草使用的措施，并调查 在拉丁美洲/e成年吸烟者（N=150）中，通过进行交叉 分段研究研究人员将重点关注弗吉尼亚州服务不足的拉丁裔/e社区 需要提供双语服务的地方。该研究将在文化上 从母体研究中调整一个目标（预测ENDS风味调节对 非裔美国人薄荷醇吸烟者的烟草行为、毒性和滥用倾向）， 纳入交叉文化因素对烟草和物质的可能影响 使用.在一次亲自访问期间，将以英语或西班牙语执行一系列措施 在弗吉尼亚州的里士满或通过变焦。拉丁裔/e裔社区通常被排除在烟草之外 研究和保健服务不足以及预防药物使用。多次 在研究中，可能有着共同边缘化经历的社区被集中在一起， 忽略了这些群体之间的关键差异。这项工作的结果将有助于FDA 关于ENDS风味限制在多个交叉领域的监管影响的预测 吸烟者的身份对这些问题的回答将说明FDA在行为方面的优先事项， 成瘾，并将提供有关潜在的FDA监管后果的新数据。 对风味末端采取行动，以帮助最大限度地提高健康促进效果， 拉丁裔/e吸烟者的后果。

PROJECT SUMMARY. Smoking is a major contributor to lung cancer, which is the leading cause of cancer death among Latinx/e men (13%) and the second leading cause after breast cancer for women (10%). Little work has examined how electronic nicotine delivery system (ENDS) uptake affects tobacco use and associated toxicity among Latinx/e smokers. Recently, FDA began regulating closed-system devices like JUUL, which have captured over 70% of the ENDS market and contributed to dramatic increases in youth ENDS use. As of early 2020, flavored ENDS cartridges (a small, enclosed unit used as part of an ENDS) other than menthol/tobacco are banned in the US. However, to achieve its public health mission, the FDA must balance restricting access to ENDS flavors that appeal to youth with the need for evidence on “whether and how certain flavors may help adult cigarette smokers reduce cigarette use and switch to potentially less harmful products”. Understanding the potential of ENDS to reduce the public health burden of combusted tobacco use equitably requires a targeted study to predict how future ENDS flavor regulations will impact Latinx/e smokers. The current study will evaluate whether ENDS flavor availability affects measures of tobacco use and investigate the mechanisms of addiction among Latinx/e adult smokers (N=150) by performing a cross- sectional study. The researcher will focus on the underserved Latinx/e community of Virginia where there is a need for the availability of bilingual services. The study will be culturally adapting one aim from the parent study (Predicting effects of ENDS flavor regulations on tobacco behavior, toxicity, and abuse liability among African American menthol smokers) while incorporating the possible implications of intersecting cultural factors on tobacco and substance use. A battery of measures will be administered in English or Spanish during one in person visit in Richmond, Virginia or via Zoom. Latinx/e communities are typically excluded from tobacco research and underserved in health services, and substance use prevention. Many times communities who may share marginalized experiences are grouped together in research which ignores crucial differences between these groups. Results of this work will help the FDA make predictions about the regulatory impact of ENDS flavor restrictions across multiple intersecting identities of smokers. Answers to these questions will address FDA’s priorities in behavior and addiction and will provide new data regarding the consequences of potential FDA regulatory actions on flavor ENDS to help maximize health-promoting effects and minimize unintended consequences among Latinx/e smokers.