Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

预防老龄化人口中的感染和抗生素耐药性：转化研究和培训计划

• 批准号: 9232068
• 负责人: Lona Mody
• 金额: $ 16.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232068
• 关键词: Admission activity; Adult; Age; Age-Years; Aging; Antibiotics; Antimicrobial Resistance; Applications Grants; Award; Bacillus (bacterium); Basic Science; Capsicum; Caregivers; Caring; Clinical; Clinical Research; Clostridium difficile; Collaborations; Communicable Diseases; Comorbidity; Data; Data Set; Development; Devices; Disabled Persons; Discipline of Nursing; Education; Elderly; Environment; Epidemiology; Faculty; Fostering; Foundations; Frail Elderly; Frail Older Adults; Funding; Future Generations; Genomics; Geography; Geriatrics; Goals; Grant; Health; Healthcare; Home Nursing Care; Home environment; Hospitalization; Hospitals; Infection; Infection Control; Infection prevention; Infectious Disease Epidemiology; Institution; International; Laboratories; Laboratory Research; Learning; Length of Stay; Life; Location; Long-Term Care; Maps; Mentors; Methodology; Methods; Michigan; Microbe; Microbiology; Modeling; Molecular; Molecular Epidemiology; Morbidity - disease rate; Multiple Anatomic Sites; Nurses; Nursing Homes; Older Population; Organism; Outcome; Outcomes Research; Pathway interactions; Policies; Population; Prevalence; Prevention Research; Program Development; Public Health Schools; Quality of Care; Randomized; Research; Research Methodology; Research Personnel; Resistance; Resistance to infection; Resources; Risk; Risk Factors; Risk stratification; Role; Safety; Saints; Sampling; Scholarship; Stream; Students; Subgroup; Techniques; Testing; Training; Training Programs; Training Support; Translational Research; Unemployment; United States; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vancomycin resistant enterococcus; Vulnerable Populations; Work; aging population; base; career; career development; clinical candidate; clinical epidemiology; clinical practice; clinically significant; community based participatory research; design; evidence base; functional disability; functional status; genome sequencing; high risk; hospice environment; implantable device; improved outcome; innovation; interest; methicillin resistant Staphylococcus aureus; microbiome; mortality; multi-component intervention; multi-drug resistant pathogen; multidisciplinary; next generation; pathogen; patient oriented; patient oriented research; patient safety; programs; public health relevance; skill acquisition; skills; translational study; transmission process; vector

 DESCRIPTION (provided by applicant): The candidate's career objective is to develop a nationally and internationally known program in `Infection Prevention in Aging'. The candidate will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces antimicrobial resistance in a vulnerable older population and by training a multidisciplinary group of students, residents, fellows, nurse investigators and junior faculty who wish to conduct patient-oriented and outcomes research in infection prevention. The majority of the candidate's professional life has been dedicated to the conduct of patient-oriented research in infection prevention, establish a steady stream of research funding and organize numerous career-development programs in aging research nationally. Translation of research findings into clinical practice, particularly in nursing homes, is challenging. Frail olde adults who receive care in institutional settings are a particularly high risk of poor outcomes. Training a multidisciplinary group of junior investigators is key to design evidence-based randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in nursing homes. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to effectively mentor a multi-disciplinary group of mentees in patient-oriented research by bridging basic science, clinical and community-based participatory research programs Aim 2: To expand the candidate's clinical research program `Infection Prevention in Aging' in directions that create new and innovative opportunities for her and her mentees The candidate's research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by NIA, AHRQ, T. Franklin Williams Scholarship (now known as GEMSSTAR) and the Hartford foundation. Three federally funded grants will serve as the platform for this grant proposal: an NIA funded RO1 grant: "Targeted Infection Control Program (TIP) to reduce antimicrobial resistance and infections in Nursing Homes", NIA funded concurrent RO1: "Pathway from functional disability to antimicrobial resistance in Nursing Homes" and an AHRQ award: `AHRQ Safety Program for long-term care: CAUTI'. These federally funded studies have created rich datasets and banked microbes that will be utilized to train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the training and development include the MICHR, University of Michigan Pepper Center, UM School of Public Health, UM Patient Safety Enhancement Program (PSEP), and UM Host Microbiome Initiative.

 描述（由申请人提供）：候选人的职业目标是开发一个国内和国际知名的“老龄化感染预防”项目。候选人将通过开展以患者为导向的研究来实现这一目标，以改善传染病的结果并减少弱势老年人群的抗菌素耐药性，并培训由学生、住院医生、研究员、护士调查员和初级教员组成的多学科小组，他们希望在感染预防方面进行以患者为导向的结果研究。候选人的大部分职业生涯都致力于开展以患者为中心的感染预防研究，建立稳定的研究经费，并在全国范围内组织许多老龄化研究的职业发展项目。将研究成果转化为临床实践，尤其是在疗养院，具有挑战性。在机构环境中接受护理的体弱老年人出现不良结果的风险特别高。培训由初级研究人员组成的多学科小组是设计循证随机研究的关键，以测试减少疗养院感染和抗菌药物耐药性的创新模型和实践。因此，该提案的总体目标是： 目标 1：通过连接基础科学、临床和社区参与性研究项目，增强候选人有效指导多学科受训者小组进行以患者为导向的研究的能力 目标 2：扩大候选人的临床研究项目“老龄化感染预防”，为她和她的受训者创造新的创新机会 候选人的研究汇集了老年病学方面的专业知识 以及衰老研究、微生物学和传染病、流行病学、结果研究、护理等。她在减少弱势群体感染和抗菌素耐药性方面的工作最初由 NIA、AHRQ、T. Franklin Williams 奖学金（现称为 GEMSSTAR）和哈特福德基金会资助。三项联邦资助的赠款将作为该赠款提案的平台：NIA 资助的 RO1 赠款：“有针对性的感染控制计划（TIP），以减少疗养院的抗菌药物耐药性和感染”，NIA 资助的并发 RO1：“疗养院从功能性残疾到抗菌药物耐药性的途径”和 AHRQ 奖项：“AHRQ 长期护理安全计划：CAUTI”。这些联邦政府资助的研究创建了丰富的数据集和微生物库，将用于培训学员进行以患者为导向的研究，并扩展到分子流行病学和基于社区的参与性研究。支持培训和发展的资源包括 MICHR、密歇根大学胡椒中心、密西根大学公共卫生学院、密西根大学患者安全增强计划 (PSEP) 和密西根大学宿主微生物组计划。