Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

预防老龄化人口中的感染和抗生素耐药性：转化研究和培训计划

• 批准号: 9232068
• 负责人: Lona Mody
• 金额: $ 16.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232068
• 关键词: Admission activity; Adult; Age; Age-Years; Aging; Antibiotics; Antimicrobial Resistance; Applications Grants; Award; Bacillus (bacterium); Basic Science; Capsicum; Caregivers; Caring; Clinical; Clinical Research; Clostridium difficile; Collaborations; Communicable Diseases; Comorbidity; Data; Data Set; Development; Devices; Disabled Persons; Discipline of Nursing; Education; Elderly; Environment; Epidemiology; Faculty; Fostering; Foundations; Frail Elderly; Frail Older Adults; Funding; Future Generations; Genomics; Geography; Geriatrics; Goals; Grant; Health; Healthcare; Home Nursing Care; Home environment; Hospitalization; Hospitals; Infection; Infection Control; Infection prevention; Infectious Disease Epidemiology; Institution; International; Laboratories; Laboratory Research; Learning; Length of Stay; Life; Location; Long-Term Care; Maps; Mentors; Methodology; Methods; Michigan; Microbe; Microbiology; Modeling; Molecular; Molecular Epidemiology; Morbidity - disease rate; Multiple Anatomic Sites; Nurses; Nursing Homes; Older Population; Organism; Outcome; Outcomes Research; Pathway interactions; Policies; Population; Prevalence; Prevention Research; Program Development; Public Health Schools; Quality of Care; Randomized; Research; Research Methodology; Research Personnel; Resistance; Resistance to infection; Resources; Risk; Risk Factors; Risk stratification; Role; Safety; Saints; Sampling; Scholarship; Stream; Students; Subgroup; Techniques; Testing; Training; Training Programs; Training Support; Translational Research; Unemployment; United States; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vancomycin resistant enterococcus; Vulnerable Populations; Work; aging population; base; career; career development; clinical candidate; clinical epidemiology; clinical practice; clinically significant; community based participatory research; design; evidence base; functional disability; functional status; genome sequencing; high risk; hospice environment; implantable device; improved outcome; innovation; interest; methicillin resistant Staphylococcus aureus; microbiome; mortality; multi-component intervention; multi-drug resistant pathogen; multidisciplinary; next generation; pathogen; patient oriented; patient oriented research; patient safety; programs; public health relevance; skill acquisition; skills; translational study; transmission process; vector

 DESCRIPTION (provided by applicant): The candidate's career objective is to develop a nationally and internationally known program in `Infection Prevention in Aging'. The candidate will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces antimicrobial resistance in a vulnerable older population and by training a multidisciplinary group of students, residents, fellows, nurse investigators and junior faculty who wish to conduct patient-oriented and outcomes research in infection prevention. The majority of the candidate's professional life has been dedicated to the conduct of patient-oriented research in infection prevention, establish a steady stream of research funding and organize numerous career-development programs in aging research nationally. Translation of research findings into clinical practice, particularly in nursing homes, is challenging. Frail olde adults who receive care in institutional settings are a particularly high risk of poor outcomes. Training a multidisciplinary group of junior investigators is key to design evidence-based randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in nursing homes. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to effectively mentor a multi-disciplinary group of mentees in patient-oriented research by bridging basic science, clinical and community-based participatory research programs Aim 2: To expand the candidate's clinical research program `Infection Prevention in Aging' in directions that create new and innovative opportunities for her and her mentees The candidate's research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by NIA, AHRQ, T. Franklin Williams Scholarship (now known as GEMSSTAR) and the Hartford foundation. Three federally funded grants will serve as the platform for this grant proposal: an NIA funded RO1 grant: "Targeted Infection Control Program (TIP) to reduce antimicrobial resistance and infections in Nursing Homes", NIA funded concurrent RO1: "Pathway from functional disability to antimicrobial resistance in Nursing Homes" and an AHRQ award: `AHRQ Safety Program for long-term care: CAUTI'. These federally funded studies have created rich datasets and banked microbes that will be utilized to train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the training and development include the MICHR, University of Michigan Pepper Center, UM School of Public Health, UM Patient Safety Enhancement Program (PSEP), and UM Host Microbiome Initiative.

 描述（由申请人提供）：候选人的职业目标是开发国内和国际知名的“老年感染预防”项目。候选人将通过开展以患者为导向的研究来实现这一目标，该研究旨在改善传染病的结果并减少脆弱的老年人群中的抗菌素耐药性，并通过培训一个多学科的学生，居民，研究员，护士调查员和初级教师小组，他们希望在感染预防中进行以患者为导向的结果研究。候选人的大部分职业生涯都致力于开展以患者为导向的感染预防研究，建立稳定的研究资金流，并在全国范围内组织众多的老龄化研究职业发展计划。将研究结果转化为临床实践，特别是在养老院，是具有挑战性的。在机构环境中接受护理的体弱老年人结局不佳的风险特别高。培训一个多学科的初级研究人员小组是设计循证随机研究的关键，以测试减少养老院感染和抗菌素耐药性的创新模式和实践。因此，本提案的总体目标是：目标1：通过将基础科学、临床和基于社区的参与性研究计划联系起来，提高候选人在以患者为导向的研究中有效指导多学科受指导者群体的能力目标2：扩大候选人的临床研究计划。“老龄化感染预防”的方向，为她和她的学员创造新的和创新的机会。候选人的研究汇集了老年医学和老龄化研究的专业知识，微生物学和传染病，流行病学，结果研究，护理和其他。她在减少弱势群体感染和抗菌素耐药性方面的工作源于最初由NIA，AHRQ，T。富兰克林威廉姆斯奖学金（现称为GEMSSTAR）和哈特福德基金会。三个联邦资助的赠款将作为该赠款提案的平台：NIA资助的RO1赠款：“有针对性的感染控制计划（TIP），以减少护理之家的抗菌素耐药性和感染”，NIA资助的并行RO1：“护理之家从功能残疾到抗菌素耐药性的途径”和AHRQ奖：“AHRQ长期护理安全计划：CITTI”。这些由联邦政府资助的研究创建了丰富的数据集和微生物库，这些数据集和微生物库将用于培训学员进行以患者为导向的研究，并扩展到分子流行病学和基于社区的参与性研究。支持培训和发展的资源包括MICHR，密歇根大学胡椒中心，UM公共卫生学院，UM患者安全增强计划（PSEP）和UM宿主微生物组计划。