Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

 应聘者描述(由申请人提供)：应聘者的职业目标是发展一个全国和国际知名的‘老年感染预防’项目。候选人将通过以下方式实现这一目标：进行以患者为导向的研究，以改善易受感染的老年人口的结果并减少抗菌素耐药性；通过培训希望在感染预防方面进行以患者为导向和结果研究的学生、住院医生、研究员、护士研究员和初级教员的多学科小组。这位候选人的大部分职业生涯都致力于进行以患者为中心的感染预防研究，建立稳定的研究资金来源，并在全国范围内组织许多老龄研究的职业发展计划。将研究成果转化为临床实践，特别是在疗养院，是具有挑战性的。在机构环境中接受护理的虚弱老年人预后不良的风险特别高。培训一组多学科的初级调查人员是设计基于证据的随机研究的关键，以测试减少养老院感染和抗菌素耐药性的创新模式和做法。因此，这项建议的总体目标是：目标1：通过将基础科学、临床和社区参与性研究计划联系起来，提高候选人在以患者为导向的研究中有效指导多学科指导对象的能力。目标2：扩大候选人的临床研究计划“老年感染预防”的方向，为她和她的指导对象创造新的创新机会。候选人的研究汇集了老年病学和老龄研究、微生物学和传染病、流行病学、结果研究、护理等方面的专业知识。她在减少脆弱人群感染和抗菌素耐药性方面的工作源于NIA、AHRQ、T·富兰克林·威廉姆斯奖学金(现在称为GEMSSTAR)和哈特福德基金会最初资助的工作。三个联邦资助的赠款将作为这一赠款提案的平台：NIA资助的RO1赠款：“减少养老院抗菌素耐药性和感染的针对性感染控制计划(TIP)”，NIA资助的同时RO1：“疗养院从功能性残疾到抗菌素耐药性的途径”，以及AHRQ奖：“AHRQ长期护理安全计划：CAUTI”。这些由联邦政府资助的研究创建了丰富的数据集和微生物库，将用于培训指导对象进行以患者为导向的研究，并将其扩展到分子流行病学和基于社区的参与性研究。支持培训和发展的资源包括MICHR、密歇根大学胡椒中心、密歇根大学公共卫生学院、密歇根大学患者安全增强计划(PSEP)和密歇根大学宿主微生物组倡议。

 DESCRIPTION (provided by applicant): The candidate's career objective is to develop a nationally and internationally known program in `Infection Prevention in Aging'. The candidate will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces antimicrobial resistance in a vulnerable older population and by training a multidisciplinary group of students, residents, fellows, nurse investigators and junior faculty who wish to conduct patient-oriented and outcomes research in infection prevention. The majority of the candidate's professional life has been dedicated to the conduct of patient-oriented research in infection prevention, establish a steady stream of research funding and organize numerous career-development programs in aging research nationally. Translation of research findings into clinical practice, particularly in nursing homes, is challenging. Frail olde adults who receive care in institutional settings are a particularly high risk of poor outcomes. Training a multidisciplinary group of junior investigators is key to design evidence-based randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in nursing homes. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to effectively mentor a multi-disciplinary group of mentees in patient-oriented research by bridging basic science, clinical and community-based participatory research programs Aim 2: To expand the candidate's clinical research program `Infection Prevention in Aging' in directions that create new and innovative opportunities for her and her mentees The candidate's research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by NIA, AHRQ, T. Franklin Williams Scholarship (now known as GEMSSTAR) and the Hartford foundation. Three federally funded grants will serve as the platform for this grant proposal: an NIA funded RO1 grant: "Targeted Infection Control Program (TIP) to reduce antimicrobial resistance and infections in Nursing Homes", NIA funded concurrent RO1: "Pathway from functional disability to antimicrobial resistance in Nursing Homes" and an AHRQ award: `AHRQ Safety Program for long-term care: CAUTI'. These federally funded studies have created rich datasets and banked microbes that will be utilized to train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the training and development include the MICHR, University of Michigan Pepper Center, UM School of Public Health, UM Patient Safety Enhancement Program (PSEP), and UM Host Microbiome Initiative.