Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

预防老龄化人口中的感染和抗生素耐药性：转化研究和培训计划

• 批准号: 10586080
• 负责人: Lona Mody
• 金额: $ 11.49万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586080
• 关键词: Accounting; Acute; Admission activity; Aging; Antibiotic Therapy; Antimicrobial Resistance; Applications Grants; Area; Bacterial Infections; COVID-19 mortality; COVID-19 survivors; Capsicum; Cardiovascular Diseases; Career Choice; Caring; Clinical; Cognitive; Collaborations; Communicable Diseases; Data Set; Databases; Dedications; Development; Diabetes Mellitus; Diagnostic; Discipline of Nursing; Education; Elderly; Environment; Environmental Pollution; Epidemiology; Event; Face; Faculty; Foundations; Frail Elderly; Funding; Geriatrics; Goals; Grant; Guidelines; Health; Health Care Costs; Health Professional; Healthcare; Healthcare Systems; High Prevalence; Hospitals; Individual; Infection; Infection Control; Infection prevention; Institution; Insurance; Integration Host Factors; Internal Medicine; International; Intervention; Intervention Studies; K-Series Research Career Programs; Lead; Length of Stay; Life; Link; Long-Term Care; Measures; Medicaid; Medicare; Medicine; Mentors; Mentorship; Metadata; Michigan; Microbe; Microbiology; Modeling; Molecular Epidemiology; Movement; Nose; Nursing Homes; Obesity; Older Population; Operative Surgical Procedures; Outcome; Outcomes Research; Paper; Patient Care; Patients; Patients' Rooms; Persons; Pharyngeal structure; Population; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Precision Health; Predisposition; Prevention program; Privatization; Public Health Schools; Publications; Publishing; Quality of Care; Randomized; Recreation; Research; Research Personnel; Resistance to infection; Resources; Respiratory Tract Infections; Risk; Role; SARS-CoV-2 infection history; Safety; Sampling; Scholarship; Shapes; Stream; Structure; System; Testing; Training; Training Programs; Translational Research; Unemployment; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Variant; Viral; Virus Diseases; Visit; Vulnerable Populations; Work; acute care; adverse outcome; aging population; antimicrobial; career; career development; career life balance; clinical diagnostics; clinical practice; cohort; community based participatory research; comorbidity; data repository; design; detection method; disability; evidence base; health care delivery; healthcare-associated infections; high risk; improved outcome; indexing; infection management; innovation; medical appointment; medical schools; meetings; microbiome; multi-drug resistant pathogen; multidisciplinary; next generation; novel; pathogen; pathogenic bacteria; pathogenic virus; patient oriented research; patient safety; post SARS-CoV-2 infection; professor; programs; rapid technique; research study; respiratory; response; risk minimization; systemic barrier; tenure track; transmission process; viral transmission

ABSTRACT Frail older adults in institutional settings such as hospitals and nursing homes (NHs) are at a particularly high risk of poor outcomes. Translation of research findings into clinical practice, particularly in NHs, is challenging. Educating and training a multidisciplinary group of junior investigators is key to designing evidence-based, randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in NH settings. In order to continue her well-established translational research, Dr. Lona Mody, Amanda Sanford Hickey Professor of Internal Medicine at the University of Michigan, is submitting this K24 renewal proposal. Dr. Mody’s career objective is to develop a nationally and internationally recognized program in infection prevention among susceptible populations. She will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces transmission of bacterial and viral infections in a vulnerable older population and by educating and training a multidisciplinary group of mentees. The majority of her professional life has been dedicated to the conduct of patient-oriented research. During the past 5 years, she has published 90 papers, including six articles pertaining to career development and work-life balance. Fifty-three were as first or senior author (59% of 90) and 59 publications were mentor/mentee collaborations (66% of 90). Several of her mentees have received career development awards including GEMSSTAR, K awards and institutional career development grants leading to independent academic careers and tenure track positions. She has established a steady stream of research funding and effective mentorship, with continued collaboration throughout the course of mentees’ careers. Dr. Mody’s research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing, and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by the NIA, AHRQ, CDC, T. Franklin Williams Scholarship (now known as GEMSSTAR), and the Hartford Foundation. Several currently funded grants will serve as the platform for this grant proposal, including ongoing work funded by NIH, AHRQ, VA, and the Kahn Foundation. These studies will yield rich datasets and banked microbes that will be utilized to educate and train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the education, training, and development include the University of Michigan Medical School, VA Ann Arbor Healthcare System, UM Department of Medicine, UM Department of Surgery, Michigan Institute for Clinical and Health Research (MICHR, UM-CTSA), UM OAIC Pepper Center, and the UM School of Public Health.

摘要 在医院和疗养院等机构环境中，虚弱的老年人处于特别高的水平。 不良后果的风险。将研究结果转化为临床实践，特别是在NHS中， 挑战性教育和培训一个多学科的初级研究人员小组是设计 以证据为基础的随机研究，以测试减少感染的创新模式和做法， NH环境中的抗菌素耐药性。为了继续她完善的翻译研究，博士。 Lona Mody是密歇根大学的阿曼达桑福德·希基内科学教授， 提交K24更新提案。Mody博士的职业目标是在国内和国际上发展 在易感人群中开展公认的感染预防方案。她将通过以下方式实现这一目标： 开展以患者为导向的研究，改善传染病的结果， 预防细菌和病毒感染在脆弱的老年人口中的传播，并通过教育和培训， 多学科学员小组。她的大部分职业生涯都致力于 以病人为中心的研究。在过去的5年里，她发表了90篇论文，其中包括6篇文章 关于职业发展和工作与生活的平衡。53人是第一或资深作者（占90人的59%） 59篇出版物是导师/学员合作（占90篇的66%）。她的几位学员已经收到了 职业发展奖，包括GEMSSTAR、K奖和机构职业发展赠款 导致独立的学术生涯和终身职位。她建立了一个稳定的 研究经费和有效的指导，并在整个过程中继续合作的学员 careers. 博士Mody的研究汇集了老年医学和衰老研究，微生物学和传染病方面的专业知识， 疾病，流行病学，结果研究，护理和其他。她在减少感染方面的工作， 脆弱人群的抗菌素耐药性源于最初由NIA，AHRQ， CDC，T.富兰克林威廉姆斯奖学金（现称为GEMSSTAR）和哈特福德基金会。几 目前资助的赠款将作为本赠款提案的平台，包括由资助的正在进行的工作 NIH、AHRQ、VA和Kahn基金会。这些研究将产生丰富的数据集和微生物库， 将被用来教育和培训学员在以病人为导向的研究与扩展的分子 流行病学和社区参与性研究。支持教育、培训和 发展包括密歇根大学医学院，弗吉尼亚州安阿伯医疗保健系统，UM 密歇根大学医学系密歇根大学临床与健康研究所外科系 （MICHR，UM-CTSA），UM OAIC胡椒中心和UM公共卫生学院。