Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

预防老龄化人口中的感染和抗生素耐药性：转化研究和培训计划

• 批准号: 10586080
• 负责人: Lona Mody
• 金额: $ 11.49万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586080
• 关键词: Accounting; Acute; Admission activity; Aging; Antibiotic Therapy; Antimicrobial Resistance; Applications Grants; Area; Bacterial Infections; COVID-19 mortality; COVID-19 survivors; Capsicum; Cardiovascular Diseases; Career Choice; Caring; Clinical; Cognitive; Collaborations; Communicable Diseases; Data Set; Databases; Dedications; Development; Diabetes Mellitus; Diagnostic; Discipline of Nursing; Education; Elderly; Environment; Environmental Pollution; Epidemiology; Event; Face; Faculty; Foundations; Frail Elderly; Funding; Geriatrics; Goals; Grant; Guidelines; Health; Health Care Costs; Health Professional; Healthcare; Healthcare Systems; High Prevalence; Hospitals; Individual; Infection; Infection Control; Infection prevention; Institution; Insurance; Integration Host Factors; Internal Medicine; International; Intervention; Intervention Studies; K-Series Research Career Programs; Lead; Length of Stay; Life; Link; Long-Term Care; Measures; Medicaid; Medicare; Medicine; Mentors; Mentorship; Metadata; Michigan; Microbe; Microbiology; Modeling; Molecular Epidemiology; Movement; Nose; Nursing Homes; Obesity; Older Population; Operative Surgical Procedures; Outcome; Outcomes Research; Paper; Patient Care; Patients; Patients' Rooms; Persons; Pharyngeal structure; Population; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Precision Health; Predisposition; Prevention program; Privatization; Public Health Schools; Publications; Publishing; Quality of Care; Randomized; Recreation; Research; Research Personnel; Resistance to infection; Resources; Respiratory Tract Infections; Risk; Role; SARS-CoV-2 infection history; Safety; Sampling; Scholarship; Shapes; Stream; Structure; System; Testing; Training; Training Programs; Translational Research; Unemployment; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Variant; Viral; Virus Diseases; Visit; Vulnerable Populations; Work; acute care; adverse outcome; aging population; antimicrobial; career; career development; career life balance; clinical diagnostics; clinical practice; cohort; community based participatory research; comorbidity; data repository; design; detection method; disability; evidence base; health care delivery; healthcare-associated infections; high risk; improved outcome; indexing; infection management; innovation; medical appointment; medical schools; meetings; microbiome; multi-drug resistant pathogen; multidisciplinary; next generation; novel; pathogen; pathogenic bacteria; pathogenic virus; patient oriented research; patient safety; post SARS-CoV-2 infection; professor; programs; rapid technique; research study; respiratory; response; risk minimization; systemic barrier; tenure track; transmission process; viral transmission

ABSTRACT Frail older adults in institutional settings such as hospitals and nursing homes (NHs) are at a particularly high risk of poor outcomes. Translation of research findings into clinical practice, particularly in NHs, is challenging. Educating and training a multidisciplinary group of junior investigators is key to designing evidence-based, randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in NH settings. In order to continue her well-established translational research, Dr. Lona Mody, Amanda Sanford Hickey Professor of Internal Medicine at the University of Michigan, is submitting this K24 renewal proposal. Dr. Mody’s career objective is to develop a nationally and internationally recognized program in infection prevention among susceptible populations. She will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces transmission of bacterial and viral infections in a vulnerable older population and by educating and training a multidisciplinary group of mentees. The majority of her professional life has been dedicated to the conduct of patient-oriented research. During the past 5 years, she has published 90 papers, including six articles pertaining to career development and work-life balance. Fifty-three were as first or senior author (59% of 90) and 59 publications were mentor/mentee collaborations (66% of 90). Several of her mentees have received career development awards including GEMSSTAR, K awards and institutional career development grants leading to independent academic careers and tenure track positions. She has established a steady stream of research funding and effective mentorship, with continued collaboration throughout the course of mentees’ careers. Dr. Mody’s research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing, and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by the NIA, AHRQ, CDC, T. Franklin Williams Scholarship (now known as GEMSSTAR), and the Hartford Foundation. Several currently funded grants will serve as the platform for this grant proposal, including ongoing work funded by NIH, AHRQ, VA, and the Kahn Foundation. These studies will yield rich datasets and banked microbes that will be utilized to educate and train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the education, training, and development include the University of Michigan Medical School, VA Ann Arbor Healthcare System, UM Department of Medicine, UM Department of Surgery, Michigan Institute for Clinical and Health Research (MICHR, UM-CTSA), UM OAIC Pepper Center, and the UM School of Public Health.

抽象的 医院和疗养院 (NH) 等机构环境中的体弱老年人的患病率特别高 不良结果的风险。将研究成果转化为临床实践，特别是在 NH 中， 具有挑战性的。教育和培训多学科的初级研究人员小组是设计的关键 基于证据的随机研究，以测试减少感染和减少感染的创新模型和实践 NH 环境中的抗菌药物耐药性。为了继续她完善的转化研究，博士。 罗娜·莫迪 (Lona Mody) 是密歇根大学阿曼达·桑福德·希基 (Amanda Sanford Hickey) 内科医学教授 提交此 K24 续订提案。莫迪博士的职业目标是在国内和国际上发展 公认的易感人群感染预防计划。她将通过以下方式实现这一目标 开展以患者为中心的研究，以改善传染病的结果并减少 细菌和病毒感染在脆弱的老年人群中传播，并通过教育和培训 多学科的受训者小组。她职业生涯的大部分时间都致力于开展 以患者为导向的研究。近5年发表论文90篇，其中论文6篇 关于职业发展和工作与生活的平衡。 53 人是第一作者或资深作者（90 人中的 59%） 59 篇出版物是导师/受训者合作的（90 篇文章中的 66%）。她的几名学员已获得 职业发展奖，包括 GEMSSTAR、K 奖和机构职业发展补助金 导致独立的学术生涯和终身教职。她已经建立了源源不断的 研究经费和有效的指导，并在受指导者的整个过程中持续合作 职业生涯。 莫迪博士的研究汇集了老年医学和衰老研究、微生物学和传染病方面的专业知识 疾病、流行病学、结果研究、护理等。她在减少感染方面的工作 弱势群体的抗菌药物耐药性源于 NIA、AHRQ 最初资助的工作， CDC、T. Franklin Williams 奖学金（现称为 GEMSSTAR）和哈特福德基金会。一些 目前资助的赠款将作为该赠款提案的平台，包括由以下机构资助的正在进行的工作 NIH、AHRQ、VA 和卡恩基金会。这些研究将产生丰富的数据集和微生物库 将用于教育和培训学员进行以患者为导向的研究，并扩展到分子研究 流行病学和基于社区的参与性研究。支持教育、培训和培训的资源 开发项目包括密歇根大学医学院、VA Ann Arbor 医疗系统、UM 密歇根大学医学系 密歇根临床与健康研究所外科系 （MICHR、UM-CTSA）、UM OAIC 胡椒中心和 UM 公共卫生学院。