Clinical Characterization Core

临床表征核心

• 批准号: 9388748
• 负责人: Kelly Powell
• 金额: $ 42.61万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9388748
• 关键词: Area; Attention; Autistic Disorder; Behavior; Behavioral; Biological; Biopsy; Caring; Child; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Skills; Communication; Complex; Consult; Consultations; Data; Data Collection; Databases; Date of birth; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Eligibility Determination; Enrollment; Ensure; Ethics; Evaluation; Faculty; Family; Feedback; Fellowship Program; Functional Imaging; Human Resources; Image; Individual; Infant; International; Internships; Knowledge; Leadership; Length; Maintenance; Measures; Mentors; Mentorship; Mission; Modeling; National Institute of Child Health and Human Development; Neonatal; Online Systems; Parents; Participant; Pathway interactions; Postdoctoral Fellow; Procedures; Process; Prospective Studies; Protocols documentation; Psychology; Psychometrics; Quality Control; Recommendation; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Running; Schedule; School-Age Population; Science; Scientific Advances and Accomplishments; Secure; Skin; Social Workers; Standardization; Supervision; Symptoms; Technical Expertise; Time; Toddler; Training; Training Support; Training and Education; Validity and Reliability; Visit; c new; cellular imaging; clinical care; cohort; cost effectiveness; desensitization; design; evidence base; experience; family support; fetal; follow-up; high risk infant; imaging approach; interdisciplinary approach; meetings; member; molecular imaging; neurodevelopment; next generation; pre-doctoral; prevent; programs; psychologic; retention rate; screening; skills; success; synergism; training opportunity; training project; undergraduate student

SUMMARY The Clinical Characterization Core (CC Core) has been carefully designed to support the science proposed in the five individual Projects while also advancing the ACE Center’s integrative mission: utilizing interdisciplinary approaches to answer critical questions about underlying mechanisms and biological pathways implicated in the expression of ASD-related symptoms across developmental epochs spanning fetal and neonatal, infant and toddler, as well as school aged periods. The overarching purpose of the CC Core is to provide the recruitment and scheduling infrastructure across all five ACE Projects, as well as comprehensive clinical characterization for all participants. The CC core draws on a highly trained group of clinicians and support staff who have extensive knowledge and long-standing experience working with individuals with ASD and their families. Centralizing the recruitment, scheduling, and clinical characterization efforts across Projects will ensure cost effectiveness, while capitalizing on expert clinical and technical skills. The CC Core will perform, assist, train, and support the implementation of a comprehensive set of characterization procedures. Moreover, the CC Core will train both pre and post-doctoral fellows. Clinical staff will consult as well as assist Project personnel in evidenced based strategies to use while working with children with ASD in order to increase the success rate of participant completion during experimental procedures. The Core’s objectives include: (1) supporting the various projects in executing highly complex daily operational and organizational tasks including recruitment and scheduling; (2) promoting synergy across projects via facilitation of enrollment in all eligible studies; (3) providing well-characterized cohorts of participants to the various project areas at the highest possible level of expertise, validity, and reliability; (4) maintaining reliability and validity, as well as other standards of clinical care, education, and training; (5) making available behavioral, diagnostic, and psychometric expertise to all Core users; (6) making data readily available to other investigators and to comply with NDAR requests. Via advancing these objectives, we will ensure cost effectiveness and quality control is maximized.

总结 临床表征核心（CC核心）经过精心设计，以支持 五个独立的项目，同时也推进ACE中心的综合使命：利用跨学科 方法来回答有关的潜在机制和生物学途径的关键问题， ASD相关症状在胎儿、新生儿、婴儿、 幼儿期和学龄期。CC核心的首要目的是提供 所有五个ACE项目的招聘和调度基础设施，以及全面的临床 对所有参与者的描述。CC核心由训练有素的临床医生和支持人员组成 谁拥有广泛的知识和长期的经验与个人与ASD和他们的 家庭在项目中集中招募、安排和临床表征工作将 确保成本效益，同时利用专业的临床和技术技能。CC核心将执行， 协助、培训和支持实施一套全面的表征程序。此外，委员会认为， CC核心将培训博士前和博士后研究员。临床工作人员将咨询并协助项目 在与ASD儿童一起工作时使用基于证据的策略， 参与者在实验过程中完成的成功率。核心的目标包括：（1） 支持各种项目执行高度复杂的日常运营和组织任务，包括 招聘和时间安排;（2）通过促进所有符合条件的项目的招生，促进项目之间的协同作用 研究;（3）为各个项目领域提供特征鲜明的参与者群体， 可能的专业水平，有效性和可靠性;（4）保持可靠性和有效性，以及其他 临床护理、教育和培训标准;（5）提供行为、诊断和 心理测量专业知识的所有核心用户;（6）使数据随时提供给其他调查人员，并遵守 NDAR请求。通过推进这些目标，我们将确保成本效益和质量控制 最大化。