Clinical Characterization Core

临床表征核心

• 批准号: 10240566
• 负责人: Kelly Powell
• 金额: $ 46.66万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240566
• 关键词: Area; Attention; Behavior; Behavioral; Biological; Biopsy; Caring; Child; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Skills; Communication; Complex; Consult; Consultations; Data; Data Collection; Databases; Date of birth; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Enrollment; Ensure; Ethics; Evaluation; Faculty; Family; Feedback; Fellowship Program; Functional Imaging; Human Resources; Image; Individual; Infant; Infrastructure; International; Internships; Knowledge; Leadership; Length; Maintenance; Measures; Mentors; Mentorship; Mission; Modeling; National Institute of Child Health and Human Development; Neonatal; Online Systems; Parents; Participant; Pathway interactions; Patient Recruitments; Postdoctoral Fellow; Procedures; Process; Prospective Studies; Protocols documentation; Psychology; Psychometrics; Quality Control; Recommendation; Reporting; Research; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Running; Schedule; School-Age Population; Science; Scientific Advances and Accomplishments; Secure; Skin; Social Workers; Standardization; Supervision; Symptoms; Technical Expertise; Time; Toddler; Training; Training Support; Training and Education; Validity and Reliability; Visit; autism spectrum disorder; autistic children; c new; cellular imaging; clinical care; cohort; cost effectiveness; desensitization; design; evidence base; experience; family support; fetal; follow-up; high risk infant; imaging approach; individuals with autism spectrum disorder; interdisciplinary approach; meetings; member; molecular imaging; neurodevelopment; next generation; participant retention; pre-doctoral; prevent; programs; psychologic; recruit; retention rate; screening; skills; success; synergism; training opportunity; training project; undergraduate student

SUMMARY The Clinical Characterization Core (CC Core) has been carefully designed to support the science proposed in the five individual Projects while also advancing the ACE Center’s integrative mission: utilizing interdisciplinary approaches to answer critical questions about underlying mechanisms and biological pathways implicated in the expression of ASD-related symptoms across developmental epochs spanning fetal and neonatal, infant and toddler, as well as school aged periods. The overarching purpose of the CC Core is to provide the recruitment and scheduling infrastructure across all five ACE Projects, as well as comprehensive clinical characterization for all participants. The CC core draws on a highly trained group of clinicians and support staff who have extensive knowledge and long-standing experience working with individuals with ASD and their families. Centralizing the recruitment, scheduling, and clinical characterization efforts across Projects will ensure cost effectiveness, while capitalizing on expert clinical and technical skills. The CC Core will perform, assist, train, and support the implementation of a comprehensive set of characterization procedures. Moreover, the CC Core will train both pre and post-doctoral fellows. Clinical staff will consult as well as assist Project personnel in evidenced based strategies to use while working with children with ASD in order to increase the success rate of participant completion during experimental procedures. The Core’s objectives include: (1) supporting the various projects in executing highly complex daily operational and organizational tasks including recruitment and scheduling; (2) promoting synergy across projects via facilitation of enrollment in all eligible studies; (3) providing well-characterized cohorts of participants to the various project areas at the highest possible level of expertise, validity, and reliability; (4) maintaining reliability and validity, as well as other standards of clinical care, education, and training; (5) making available behavioral, diagnostic, and psychometric expertise to all Core users; (6) making data readily available to other investigators and to comply with NDAR requests. Via advancing these objectives, we will ensure cost effectiveness and quality control is maximized.

摘要 临床特征核心(CC核心)经过精心设计，以支持在 五个单独的项目，同时推进ACE中心的综合使命：利用跨学科 回答有关潜在机制和生物学途径的关键问题的方法 自闭症相关症状在胎儿、新生儿、婴儿各发育阶段的表达 儿童和学龄儿童以及学龄儿童。CC核心的主要目的是提供 所有五个ACE项目的招聘和调度基础设施，以及全面的临床 所有参与者的特征。CC核心由训练有素的临床医生和支持人员组成 他们拥有广泛的知识和长期的工作经验，与患有ASD的个人和他们的 家人。将跨项目的招募、计划和临床特征工作集中起来将 确保成本效益，同时利用专业的临床和技术技能。CC Core将执行、 协助、培训和支持实施一套全面的定性程序。此外， CC Core将培训博士后和博士后研究员。临床工作人员将提供咨询并协助项目 以证据为基础的策略中的人员在处理ASD儿童时使用，以增加 实验过程中参与者完成的成功率。核心的目标包括：(1) 支持各种项目执行高度复杂的日常业务和组织任务，包括 招聘和日程安排；(2)通过促进在所有符合条件的项目中登记，促进项目之间的协同 研究；(3)向最高级别的各个项目领域提供具有良好特点的参与者队列 专业知识、效度和可靠性的可能水平；(4)保持信度和效度以及其他 临床护理、教育和培训的标准；(5)提供行为、诊断和培训 向所有核心用户提供心理测量专业知识；(6)使其他调查人员随时可以获得数据并遵守 使用NDAR请求。通过推进这些目标，我们将确保成本效益和质量控制 最大化。