Advanced Technologies Core

HU CFAR的最大附加值之一是加速了成员获得新的和 新兴技术。在前两个竞争提交中，这些技术主要是 通过分子生物学和基因组学核心和免疫学核心提供。提供的服务 主要集中在基因组和流式细胞技术上，并随着时间的推移而不断发展，继续 向成员提供个别调查员无法获得的支助。基于我们 2012年CFAR战略审查，成员们得出结论认为，通过整合这些核心， 先进的免疫学和基因组学技术的交叉和日益增长的计算能力， 与此相关的挑战，我们可以更好地利用CFAR资源为成员服务。这两 因此，这些核心被合并并重新定义，以形成单个高级技术核心（ATC）。整体 新的先进技术核心的使命是提供先进的细胞计数/基因组 技术和计算方法是一个越来越具有挑战性的障碍，个人 investigators.目前，已确定的成员需求主要是获取信息 关于单个细胞的表型和功能状态，索引这些样品，然后 利用这一珍贵的生物材料来开发一个全面的基因组景观， 存在于特定的疾病状态中。为了确保所有哈佛CFAR实验室都能使用这个 这一核心具有非凡的分析能力，将通过以下目标促进获得此类技术： 1)为CFAR成员提供最先进的技术。 2)提供上述技术的用户培训以及计算协助。 3)使用最先进的共享和分发工具构建虚拟社区。

One of the greatest added values of the HU CFAR has been accelerated member access to new and emerging technologies. In the previous two competing submissions, these technologies have been largely provided through the Molecular Biology & Genomics Core and the Immunology Core. Services provided have focused largely on genomic and flow cytometic technologies, and have evolved over time, continuing to provide members with support that would be otherwise inaccessible to individual investigators. Based on our 2012 CFAR Strategic Review, the membership concluded that by integrating these cores and focusing on the intersection of advanced immunologic and genomic technologies and the increasing computational challenges associated with these, we could better leverage CFAR resources to serve members. These two cores were thus merged and redefined to form a single Advanced Technologies Core (ATC). The overall mission of the new Advanced Technologies Core is to provide access to advanced cytometric/genomic technologies and the computational methodologies that are an increasingly challenging barrier to individual investigators. At the current time, much of the identified need for members is in the capture of information regarding the phenotypic and functional state of individual cells, indexing these samples, and then capitalizing on this precious biomaterial to develop a comprehensive picture of the genomic landscape that exists in particular disease states. To ensure that all Harvard CFAR laboratories have access to this remarkable analytical power, this core will facilitate access to such technologies through the following aims: 1) Provide CFAR member access to state-of-the art technologies. 2) Providing user training in the above technologies, as well as computational assistance. 3) Building a virtual community using state of the art sharing and distribution tools.