Advanced Technologies Core

先进技术核心

• 批准号: 9111795
• 负责人: Roger Keith Reeves
• 金额: $ 33.25万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111795
• 关键词: Acquired Immunodeficiency Syndrome; Area; Biocompatible Materials; Boston; Cell Separation; Cells; Cloud Computing; Collaborations; Communities; Computing Methodologies; Containment; Dana-Farber Cancer Institute; Data; Data Set; Development; Disease; Emerging Technologies; Ensure; Epigenetic Process; Equipment; Evaluation; Flow Cytometry; Fostering; General Hospitals; Genomics; Health; Hospitals; Human; Image; Imaging technology; Immunologics; Immunology; Individual; Institutes; Institution; Instruction; Internet; Israel; Laboratories; Massachusetts; Medical; Medical center; Microscopy; Mission; Molecular Biology; Pediatric Hospitals; Preventive Intervention; Procedures; Protocols documentation; Public Health Schools; Research; Research Design; Research Personnel; Resources; Sampling; Services; Site; Sorting - Cell Movement; Specimen; Standardization; Structure; Targeted Resequencing; Technology; Therapeutic Intervention; Time; Tissues; Training; Universities; Viral; Woman; base; cytokine; indexing; medical schools; member; new technology; online community; peripheral blood; symposium; tool; transcriptome sequencing; transcriptomics; vaccine development; virus host interaction

One of the greatest added values of the HU CFAR has been accelerated member access to new and emerging technologies. In the previous two competing submissions, these technologies have been largely provided through the Molecular Biology & Genomics Core and the Immunology Core. Services provided have focused largely on genomic and flow cytometic technologies, and have evolved over time, continuing to provide members with support that would be otherwise inaccessible to individual investigators. Based on our 2012 CFAR Strategic Review, the membership concluded that by integrating these cores and focusing on the intersection of advanced immunologic and genomic technologies and the increasing computational challenges associated with these, we could better leverage CFAR resources to serve members. These two cores were thus merged and redefined to form a single Advanced Technologies Core (ATC). The overall mission of the new Advanced Technologies Core is to provide access to advanced cytometric/genomic technologies and the computational methodologies that are an increasingly challenging barrier to individual investigators. At the current time, much of the identified need for members is in the capture of information regarding the phenotypic and functional state of individual cells, indexing these samples, and then capitalizing on this precious biomaterial to develop a comprehensive picture of the genomic landscape that exists in particular disease states. To ensure that all Harvard CFAR laboratories have access to this remarkable analytical power, this core will facilitate access to such technologies through the following aims: 1) Provide CFAR member access to state-of-the art technologies. 2) Providing user training in the above technologies, as well as computational assistance. 3) Building a virtual community using state of the art sharing and distribution tools.

HU CFAR最大的附加值之一是加快了成员访问新的和 新兴技术。在前两个相互竞争的提交文件中，这些技术在很大程度上 通过分子生物学和基因组学核心以及免疫学核心提供。提供的服务 主要专注于基因组和流式细胞学技术，并随着时间的推移而演变，继续 为成员提供个别调查人员无法获得的支持。基于我们的 2012年CFAR战略审查，成员总结说，通过整合这些核心并专注于 先进的免疫学和基因组技术的交叉以及日益增长的计算能力 为了应对这些挑战，我们可以更好地利用CFAR资源为成员提供服务。这两个 因此，核心被合并和重新定义，以形成一个单一的先进技术核心(ATC)。整体而言 新的先进技术核心的使命是提供先进的细胞学/基因组学信息 技术和计算方法对个人来说是一个日益具有挑战性的障碍 调查人员。目前，确定的成员需求很大程度上是获取信息 关于单个细胞的表型和功能状态，索引这些样本，然后 利用这一珍贵的生物材料来开发一幅全面的基因组图景 存在于特定的疾病状态。为了确保所有哈佛CFAR实验室都能访问这个 这一核心具有非凡的分析能力，将通过以下目标促进此类技术的获取： 1)为CFAR成员提供最先进的技术。 2)提供上述技术方面的用户培训，以及计算辅助。 3)使用最先进的共享和分发工具构建虚拟社区。