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Integrating Hippocampus, Ventral Striatum, and Prefrontal Cortex during Deliberative Decision Making

在深思熟虑的决策过程中整合海马、腹侧纹状体和前额皮质

基本信息

批准号：
9046376
负责人：
Brandy J Schmidt
金额：
$ 6万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9046376
关键词：
Area Behavior Behavioral Cells Code Computer Analysis Conceptions Conflict (Psychology)Corpus striatum structure Data Data Analyses Decision Making Electrophysiology (science)Environment Evaluation Faculty Flavoring Food Food Preferences Funding Future Goals Grant Health Hippocampus (Brain)Hour Human Individual Institution Intervention Journals Learning Learning Skill Measures Medial Neurobiology Neurologic Neurons Outcome Physiology Play Positioning Attribute Postdoctoral Fellow Prefrontal Cortex Primates Process Publishing Rattus Research Research Personnel Restaurants Rewards Rodent Role Running Secure Site Sorting - Cell Movement Specificity System Technology Testing Therapeutic Time Training United States National Institutes of Health Ventral Striatum Viral Writing abstracting addiction cognitive process cost designer receptors exclusively activated by designer drugs expectation extracellular faculty research graduate student information processing meetings neuroeconomics neurophysiology novel relating to nervous system simulation tenure track theories willingness

项目摘要

DESCRIPTION (provided by applicant): How does decision making go awry in addiction? Decision making processes have been extensively studied in humans, primates, and rodents. However, we still do not fully understand the neurophysiological processes supporting decision making. In order to answer how decision making goes awry, we must first ask how we make decisions. Maladaptive decision making could result from an error in processing in one or several decision making systems or a conflict between different decision making systems. Consequently, we need to establish a better understanding of the mechanisms of deliberative decision making in order to understand the neurological causes of maladaptive decision making. I propose to utilize a novel viral technology (DREADD) to examine how three neural systems integrate information during deliberative decision making. I propose to examine how the ventral striatum evaluates reward, how the hippocampus imagines the future, how the prefrontal cortex biases hippocampal representations of context, and finally how these three systems interact/bias each other during deliberative decision making. I propose to simultaneously record neuronal ensembles and local field potentials from the prefrontal cortex, hippocampus and ventral striatum in rats trained on a spatial neuroeconomic task (Restaurant Row). On the Restaurant Row task rats are presented with the option of different food rewards dispensed after variable random delays. The rats have the choice of waiting out the delay for the food reward or skipping the choice and moving on to the next reward site. Combining large ensemble recordings with sophisticated computational analyses permits us to measure neural processes at incredibly fast time-scales (ms vs. minutes and hours). By doing so we can better analyze neural processes at time-scales more analogous to the temporal specificity that characterizes information processing seen during decision-making (Johnson et al., 2009). Therefore, we can extrapolate abstract cognitive processes, such as decision-making, from concrete neurobiological processes. This proposal aims to examine three questions: 1) what are the effects of silencing the prefrontal cortex on behavioral correlates of the dynamic search and evaluation processes (VTE) seen during decision-making, 2) is there a causal relationship between PFC and hippocampal spatial representations of prediction/planning and/or ventral striatum covert expectations of reward, 3) does silencing the prefrontal cortex impair off-line coordinated hippocampal-ventral striatal place-reward reactivation (replay). By answering these questions we will have a better understanding of how these disparate neural systems interact during deliberative decision making and get closer to answer the question: how does decision making go awry in addiction?

描述(由申请人提供)：在上瘾的情况下，决策是如何出错的？人类、灵长类动物和啮齿动物的决策过程已被广泛研究。然而，我们仍然不完全了解支持决策的神经生理过程。为了回答决策是如何出错的，我们必须首先问一问我们是如何做出决策的。不适应决策可能是由于一个或多个决策系统中的处理错误或不同决策系统之间的冲突造成的。因此，我们需要对慎重决策的机制建立更好的理解，以便理解不适应决策的神经学原因。我建议利用一种新的病毒技术(DREADD)来研究三个神经系统如何在深思熟虑的决策过程中整合信息。我打算研究腹侧纹状体如何评估奖赏，海马体如何想象未来，前额叶皮质如何偏向海马体对背景的表征，以及最后这三个系统在审议决策过程中如何相互作用/偏见。我建议同时记录接受空间神经经济任务训练的大鼠的前额叶皮质、海马体和腹侧纹状体的神经元集合和局部场电位(Restaurant Row)。在餐厅排任务中，老鼠可以选择在可变的随机延迟后分配不同的食物奖励。老鼠可以选择等待食物奖励的延迟，也可以跳过选择，转移到下一个奖励地点。将大型整体记录与复杂的计算分析相结合，使我们能够以令人难以置信的快速时间尺度(毫秒与分钟和小时)测量神经过程。通过这样做，我们可以更好地分析时间尺度上的神经过程，更类似于决策过程中信息处理的时间特殊性(Johnson等人，2009年)。因此，我们可以从具体的神经生物学过程推断抽象的认知过程，如决策。这一建议旨在研究三个问题：1)沉默前额叶皮质对决策过程中动态搜索和评估过程(VTE)的行为相关有什么影响；2)PFC与预测/规划和/或腹侧纹状体隐性奖赏期望的海马区空间表征之间是否存在因果关系；3)沉默前额叶皮质是否会损害离线协调的海马-腹侧纹状体位置奖赏再激活(Replay)。通过回答这些问题，我们将更好地了解这些不同的神经系统在慎重决策过程中是如何相互作用的，并更接近于回答这个问题：决策是如何在上瘾时出错的？