UCSF Core Center for Musculoskeletal Biology and Medicine

拟议的加州大学旧金山分校医学肌肉骨骼生物学核心中心(CCMBM)将是一个 由39名致力于了解生物学的基础和临床科学家组成的跨学科联盟 和肌肉骨骼疾病的病理生理学。目标是刺激和支持跨学科 加州大学旧金山分校现有的一流研究项目之间的合作，以加快 骨质疏松症和骨性关节炎的翻译研究。从板凳到床边的根本挑战 翻译研究需要在人类身上验证来自小动物模型的发现。这个 提出的CCMBM将通过在研究疾病的科学家之间建立联系来克服这一障碍 生物学，分析大量临床数据的研究人员，以及积极治疗患者的从业者。 加州大学旧金山分校CCMBM提出了三个核心：1)骨骼生物学核心；2)肌肉骨骼和定量 影像核心；3)流行病学和生物统计学核心。这些核心将提供研究支持和 技术培训，以及新合作的场所和新成员的切入点。《中心》 还将通过丰富计划促进科学交流；课程包括每月一次的 以当地和来访的科学家为特色的研讨会，与外部顾问委员会的年度全天静修， 以及每季度半天的研讨会，轮流讨论与骨质疏松症和骨性关节炎相关的话题。另一个 该中心的重要组成部分是其试点/可行性计划。这为朱尼尔提供了种子资金 研究人员和刚接触肌肉骨骼研究的科学家。最后，工具和技术补助 本计划将为中心成员提供资金，以利用优秀的专业人员 加州大学旧金山分校CCMBM以外的研究服务。 总体而言，拟议的CCMBM的资金基础是强大的，加州大学旧金山分校的支持是强有力的，以及 中心内外互动的机会很多。该中心的宗旨是。 最大限度地利用所有可用资源，促进肌肉骨骼基础生物学的发现 疾病。

The proposed UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) w/ill be an interdisciplinary consortium of thirty-nine basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in osteoporosis and osteoarthritis. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between scientists who study disease biology, researchers who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology Core; 2) Musculoskeletal and Quantitative Imaging Core; and 3) Epidemiology and Biostatistics Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes a monthly seminar featuring local and visiting scientists, an annual full-day retreat with the External Advisory board, and a quarterly half-day symposium with a rotating topic relevant to osteoporosis and osteoarthritis. Another vital component of the Center is its Pilot/Feasibility Program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology Grant Program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the proposed CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to. make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.