UCSF Core Center for Musculoskeletal Biology and Medicine

加州大学旧金山分校肌肉骨骼生物学和医学核心中心

• 批准号: 9102736
• 负责人: JEFFREY C. LOTZ
• 金额: $ 60.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9102736
• 关键词: Animal Model; Archives; Area; Biology; Biostatistics Core; Clinical; Clinical Data; Collaborations; Degenerative polyarthritis; Diagnosis; Discipline; Disease; Educational Curriculum; Epidemiology; Fostering; Functional disorder; Funding; Goals; Grant; Human; Laboratories; Medicine; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Osteoporosis; Patients; Research; Research Personnel; Research Support; Resources; Scientist; Services; Specialist; Technology; Training; Translating; Translational Research; Visit; base; bench to bedside; interdisciplinary collaboration; member; musculoskeletal imaging; programs; quantitative imaging; skeletal; symposium; tool

The proposed UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) w/ill be an interdisciplinary consortium of thirty-nine basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in osteoporosis and osteoarthritis. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between scientists who study disease biology, researchers who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology Core; 2) Musculoskeletal and Quantitative Imaging Core; and 3) Epidemiology and Biostatistics Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes a monthly seminar featuring local and visiting scientists, an annual full-day retreat with the External Advisory board, and a quarterly half-day symposium with a rotating topic relevant to osteoporosis and osteoarthritis. Another vital component of the Center is its Pilot/Feasibility Program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology Grant Program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the proposed CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to. make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

拟议中的UCSF医学肌肉骨骼生物学核心中心（CCMBM）将成为一个 由39名基础和临床科学家组成的跨学科联盟，致力于了解生物学 和肌肉骨骼疾病的病理生理学。目标是激励和支持跨学科 UCSF现有的首要研究项目之间的合作，以加快 骨质疏松症和骨关节炎的转化研究。从临床到临床的根本挑战 转化研究需要在人类身上验证小动物模型的发现。的 拟议中的CCMBM将通过在研究疾病的科学家之间建立联系来克服这一障碍 生物学，分析大量临床数据档案的研究人员，以及积极治疗患者的从业人员。 UCSF CCMBM提出了三个核心：1）骨骼生物学核心; 2）肌肉骨骼和定量 影像学核心;和3）流行病学和生物统计学核心。这些核心将提供研究支持， 技术培训，以及新合作的场所和新成员的切入点。中心 还将通过丰富计划促进科学交流;课程包括每月 由当地和访问科学家参加的研讨会，与外部咨询委员会举行的年度全天务虚会， 每季度举行一次为期半天的专题讨论会，轮流讨论与骨质疏松症和骨关节炎有关的主题。另一 该中心的重要组成部分是其试点/可行性方案。这为初级教育提供了种子资金 研究人员和科学家新的肌肉骨骼研究。最后，工具和技术补助金 该计划将提供资金，以中心成员的目的，利用优秀的专业 在UCSF的CCMBM之外提供的研究服务。 总的来说，拟议的CCMBM的资金基础是强大的，来自UCSF的支持是强大的， 中心内外的互动机会很多。该中心的目标是。 充分利用所有可用资源，促进肌肉骨骼基础生物学的发现 疾病