UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain

加州大学旧金山分校建议的以患者为中心的慢性下腰痛机械表型分析中心 加州大学旧金山分校REACH将是一个由基础和临床科学家组成的跨学科联盟，致力于了解 阐明慢性腰痛(CLBP)的生物心理社会机制。加州大学旧金山分校的目标是达到 是定义慢性下腰痛(CLBP)的表型和疼痛机制，可以导致 为人群中的患者提供有效、个性化的治疗。一个根本性的挑战是 改善慢性下腰痛患者的生活是疼痛可以持续和恶化的结果，因为 有几个病人特有的因素。然而，主要因素及其相互作用仍然不清楚，因为 他们还没有在单一的纵向队列中得到严格的调查。REACH建议克服这一点 通过在研究疾病生物学的研究人员、开发先进技术的专家之间建立联系来克服障碍 研究工具和方法，分析大量临床数据档案的科学家，以及 积极救治患者。加州大学旧金山分校REACH提出六个核心：1)管理核心；2)临床核心；3)信息学 核心；4)生物行为核心；5)病理生理学核心；6)身体功能和生物力学核心。这些 核心将为专注于开发经过验证的挑战的单个研究项目提供支持 以及可采用的工具，使CLBP患者能够进行全面而常规的临床评估和治疗。 REACH还将通过丰富计划促进科学交流；课程包括研讨会 以当地和来访的科学家为特色，与外部咨询委员会举行一年一度的全天务虚会，以及 与慢性下腰痛的生物-心理-社会模型相关的轮流主题的日专题讨论会。另一个重要组成部分是 REACH是其试点/辅助研究计划。这提供了种子资金来利用REACH临床数据和 核心。总体而言，REACH的目标是最佳地利用所有可用的资源来催化发现和 翻译新的诊断和治疗方法以改善慢性下腰痛患者的预后。

The proposed UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain (UCSF REACH) will be an interdisciplinary consortium of basic and clinical scientists dedicated to understanding and clarifying the biopsychosocial mechanisms of chronic low back pain (cLBP). The goal of UCSF REACH is to define chronic low back pain (cLBP) phenotypes and pain mechanisms that can lead to effective, personalized treatments for patients across the population. A fundamental challenge for improving lives of cLBP patients is that pain can perpetuate and worsen as a result of dynamic interaction among several patient-specific factors. However, the principle factors and their interactions remain obscure because they haven't been rigorously investigated in a single longitudinal cohort. REACH proposes to overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. UCSF REACH proposes six cores: 1) Administrative Core; 2) Clinical Core; 3) Informatics Core; 4) Bio-behavioral Core; 5) Pathophysiology Core; and 6) Physical Function and Biomechanics Core. These cores will provide support to a single research project that is focused on the challenge of developing validated and adoptable tools that enable comprehensive yet routine clinical assessment and treatment of CLBP patients. REACH will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External Advisory Committee, and half- day symposia with a rotating topic relevant to the biopsychosocial model of cLBP. Another vital component of REACH is its Pilot/Ancillary Studies Program. This provides seed money to leverage REACH clinical data and cores. Overall, the object of REACH is to make optimum use of all available resources to catalyze discovery and translation of novel diagnostics and therapeutics that improve outcomes of cLBP patients.