Sub-component for Institution # 16-01848 Biostatistics

机构的子组件

• 批准号: 9283080
• 负责人: Ralph B. DAgostino
• 金额: $ 17.56万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9283080
• 关键词: Address; Animals; Area; Bioinformatics Shared Resource; Biological; Biometry; Biostatistics Core; Cancer Center; Canis familiaris; Caring; Characteristics; Clinical; Collaborations; Communities; Comprehensive Cancer Center; Computers; Consultations; Core Facility; Data; Data Base Management; Data Collection; Database Management Systems; Databases; Development; Doctor of Philosophy; Elements; Experimental Designs; Faculty; Glioblastoma; Goals; Human; Image Analysis; Information Dissemination; Institution; Lead; Leadership; Manuscripts; Measures; Methodology; Methods; Modeling; Mus; Outcome; Participant; Phase; Preparation; Procedures; Protocols documentation; Publications; Quality Control; Rattus; Research Design; Research Personnel; Resources; Sample Size; Security; Services; Specific qualifier value; Standardization; Statistical Data Interpretation; Statistical Methods; Structure; Techniques; Testing; Therapeutic; Universities; Update; Work; computer network; cost effective; data management; data visualization; design; expectation; experience; follow-up; forest; medical schools; meetings; member; programs; success

The primary goal of the Biostatistics Core (Core 2) will be to provide cost-effective, comprehensive and critical support to the four projects and cores from this P01 application entitled “Maximizing Local Access to Therapeutic Deliveries in Glioblastoma”. To do this Core 2 has assembled a team of experienced faculty and staff statisticians and programmers. The Biostatistics Core will also act as a central resource throughout all phases of the project. Members of Core 2 will assume (and has assumed) major responsibilities for methodological, statistical, and computer-related issues, including study design for all projects; data collection, data entry, and analyses; quality control; computer networking; database management; statistical methodology development; and participation in manuscript preparation. Core 2 has worked with each Project Leader to insure that each study design is adequate to address all major hypotheses. This has involved refining study hypotheses, defining primary (and when necessary, secondary) end points for each study; determining the sample sizes necessary to test each hypothesis with a specified power and level of significance, and assessing the feasibility of each study relative to its hypothesis and the projected available subject pool. Core 2 has taken care to design the statistical analysis plans for each project to contain a combination of standard and advanced statistical methods as needed. This includes using methods for longitudinal data that account for repeated measures as well as handling missing data if it were to occur. In addition, Core 2 members will look for opportunities to develop new statistical methods for analyzing imaging data and these approaches are described in the proposal. To guarantee that successful implementation of these methods occurs, Core 2 members are committed to taking an active part in the daily activities of each project. For each project one of Core 2 members will serve as a co-investigator and participate in regular meetings among investigators for that project. This model of collaboration among Core 2 members and scientific investigators has been implemented within the Cancer Center at Wake Forest University for many years with great success. In conclusion, the Biostatistics Core is an integral component of this P01. It connects the four projects together and supports all other Cores by providing centralized analytic and data management support that will allow efficient dissemination of results to flow among projects and cores, and into the scientific community.

生物统计学核心（核心2）的主要目标是提供具有成本效益，全面和关键的 支持该P01应用程序的四个项目和核心，标题为“最大化本地访问权限 胶质母细胞瘤的治疗性分娩”。 员工统计学家和程序员。生物统计学核心也将充当所有人的中心资源 项目的阶段。 Core 2的成员将承担（并已假定）对 方法论，统计和与计算机有关的问题，包括所有项目的研究设计；数据收集， 数据输入和分析；质量控制；计算机网络；数据库管理；统计方法 发展;并参与手稿准备。 Core 2已与每个项目负责人合作，以确保每个研究设计都足以解决所有主要专业 假设。这涉及精炼研究假设，定义主要（必要时，第二） 每个研究的终点；确定使用指定的样本大小来检验每个假设所需的样本量 权力和重要性水平，并评估每个研究相对于其假设的可行性和 预计可用的主题池。 Core 2已注意为每个项目设计统计分析计划 根据需要包含标准和高级统计方法的组合。这包括使用 纵向数据的方法，该方法是重复措施以及处理丢失的数据的方法 发生。此外，Core 2成员将寻找机会开发新的统计方法进行分析 成像数据和这些方法在提案中描述。 为确保成功实施这些方法，核心2成员致力于 积极参与每个项目的日常活动。对于每个项目，核心2成员将服务 作为共同投资者，并参加该项目的调查人员之间的定期会议。这个模型 核心2成员和科学研究人员之间的合作已在癌症中实施 维克森林大学的中心多年，取得了巨大的成功。总之，生物统计学核心是 此P01的积分组件。它将四个项目连接在一起，并通过提供所有其他核心 集中式分析和数据管理支持，将有效地传播结果 在项目和核心中，进入科学界。