Sub-component for Institution # 16-01848 Biostatistics

机构的子组件

• 批准号: 10220886
• 负责人: Ralph B. DAgostino
• 金额: $ 12.7万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-17 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220886
• 关键词: Address; Animals; Area; Bioinformatics Shared Resource; Biological; Biometry; Biostatistics Core; Cancer Center; Canis familiaris; Caring; Characteristics; Clinical; Collaborations; Communities; Comprehensive Cancer Center; Computers; Consultations; Core Facility; Data; Data Collection; Database Management Systems; Databases; Development; Doctor of Philosophy; Elements; Experimental Designs; Faculty; Glioblastoma; Goals; Human; Image; Information Dissemination; Institution; Lead; Leadership; Manuscripts; Measures; Methodology; Methods; Modeling; Mus; Outcome; Participant; Phase; Preparation; Procedures; Protocols documentation; Publications; Quality Control; Rattus; Research Design; Research Personnel; Resources; Sample Size; Security; Services; Specific qualifier value; Standardization; Statistical Data Interpretation; Statistical Methods; Structure; Techniques; Testing; Therapeutic; Universities; Update; Work; computer network; cost effective; data management; data visualization; design; expectation; experience; follow-up; forest; medical schools; meetings; member; programs; secondary endpoint; success

The primary goal of the Biostatistics Core (Core 2) will be to provide cost-effective, comprehensive and critical support to the four projects and cores from this P01 application entitled “Maximizing Local Access to Therapeutic Deliveries in Glioblastoma”. To do this Core 2 has assembled a team of experienced faculty and staff statisticians and programmers. The Biostatistics Core will also act as a central resource throughout all phases of the project. Members of Core 2 will assume (and has assumed) major responsibilities for methodological, statistical, and computer-related issues, including study design for all projects; data collection, data entry, and analyses; quality control; computer networking; database management; statistical methodology development; and participation in manuscript preparation. Core 2 has worked with each Project Leader to insure that each study design is adequate to address all major hypotheses. This has involved refining study hypotheses, defining primary (and when necessary, secondary) end points for each study; determining the sample sizes necessary to test each hypothesis with a specified power and level of significance, and assessing the feasibility of each study relative to its hypothesis and the projected available subject pool. Core 2 has taken care to design the statistical analysis plans for each project to contain a combination of standard and advanced statistical methods as needed. This includes using methods for longitudinal data that account for repeated measures as well as handling missing data if it were to occur. In addition, Core 2 members will look for opportunities to develop new statistical methods for analyzing imaging data and these approaches are described in the proposal. To guarantee that successful implementation of these methods occurs, Core 2 members are committed to taking an active part in the daily activities of each project. For each project one of Core 2 members will serve as a co-investigator and participate in regular meetings among investigators for that project. This model of collaboration among Core 2 members and scientific investigators has been implemented within the Cancer Center at Wake Forest University for many years with great success. In conclusion, the Biostatistics Core is an integral component of this P01. It connects the four projects together and supports all other Cores by providing centralized analytic and data management support that will allow efficient dissemination of results to flow among projects and cores, and into the scientific community.

生物统计学核心（核心 2）的主要目标是提供具有成本效益的、全面的和关键的 支持这个 P01 应用程序的四个项目和核心，题为“最大化本地访问 胶质母细胞瘤的治疗交付”。为了实现这一目标，Core 2 组建了一支由经验丰富的教职员工和 统计员和程序员。生物统计核心还将充当所有领域的中心资源 项目的各个阶段。核心 2 成员将承担（并且已经承担）以下主要职责： 方法论、统计和计算机相关问题，包括所有项目的研究设计；数据收集， 数据输入和分析；质量控制；计算机网络；数据库管理；统计方法 发展;并参与稿件准备。 核心 2 与每个项目负责人合作，确保每个研究设计足以解决所有主要问题 假设。这涉及完善研究假设，定义主要的（必要时，定义次要的） 每项研究的终点；确定用指定的条件检验每个假设所需的样本量 能力和重要性水平，并评估每项研究相对于其假设和研究的可行性 预计可用主题库。 Core 2精心设计了每个项目的统计分析计划 根据需要包含标准和高级统计方法的组合。这包括使用 用于解释重复测量以及处理缺失数据的纵向数据的方法 发生。此外，Core 2 成员将寻找机会开发新的统计方法来分析 提案中描述了成像数据和这些方法。 为了保证这些方法的成功实施，Core 2 成员致力于 积极参与每个项目的日常活动。对于每个项目，核心 2 成员之一将担任职务 作为联合调查员并参加该项目调查员之间的定期会议。这个型号的 核心 2 成员和科学研究人员之间的合作已在癌症中心内实施 在维克森林大学中心工作多年并取得巨大成功。总之，生物统计学核心是 该 P01 的组成部分。它将四个项目连接在一起并通过提供支持所有其他核心 集中分析和数据管理支持，使结果能够有效传播 项目和核心之间，并进入科学界。