Biostatistics Core

生物统计学核心

• 批准号: 7529762
• 负责人: Ralph B. DAgostino
• 金额: $ 20.93万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-11 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7529762
• 关键词: Area; Attention; Basic Science; Biometry; Biostatistics Core; Cancer Center; Cancer Center Support Grant; Cancer Control; Categories; Clinical; Clinical Research; Collaborations; Comprehensive Cancer Center; Computers; Consultations; Data Analyses; Development; Ensure; Faculty; Foundations; Funding; Genetic Research; Goals; Grant; Health Sciences; Hour; Incidence; Industry; Laboratories; Malignant Neoplasms; Manuscripts; Mission; Monitor; Monitoring Clinical Trials; Morbidity - disease rate; Patient Recruitments; Peer Review; Phase; Phase III Clinical Trials; Preparation; Principal Investigator; Productivity; Protocols documentation; Public Health; Publishing; Randomized; Reporting; Research; Research Design; Research Methodology; Research Peer Review; Research Personnel; Research Project Grants; Resources; Review Committee; Role; Sampling; Scheme; Series; Services; Surveys; Symptoms; System; Time; Treatment Protocols; United States National Institutes of Health; Universities; Work; Writing; anticancer research; design; experience; forest; health related quality of life; improved; member; programs; protocol development; response

The primary goal of the Biostatistics Core (BioC) is to facilitate the peer-reviewed research of members of the Comprehensive Cancer Center at Wake Forest University (CCCWFU). We are responsible for collaborating with clinical, cancer control and basic science investigators throughout all phases of cancerrelated research projects designed to reduce the incidence of cancer and increase treatment options, improve response and survival, reduce morbidity, manage symptoms, improve health-related quality of life, and move important laboratory discoveries into clinical practice. Major responsibilities are assumed for methodological, statistical, and computer-related issues, including study design, sampling, statistical aspects of clinical trial monitoring, interim reviews, and final analysis. Specifically, we are responsible for 1) ensuring that study designs are adequate, 2) writing the statistical sections for all treatment protocols including plans for interim monitoring of trial results, 3) developing randomization schemes for phase III clinical trials, 4) assisting with the development of sample survey instruments, 5) monitoring ongoing protocol accrual, 6) providing methodological support to CCCWFU investigators, 7) performing interim data analyses, 8) performing ad hoc and final analyses, 9) collaborating in interpreting and publishing results, 10) participating in CCCWFU committees responsible for the scientific and administrative direction of the CCCWFU, 11) conducting a monthly seminar series on topics in research methods for CCCWFU members, and 12) holding statistical assistance planning sessions regularly to assist with grant submissions. In the reported year, July 1, 2004 through June 30,2005, the BioC provided over 3,460 hours of support for cancer related work. The BioC assisted over 70 different investigators from all Programs and Centers of Excellence within the CCCWFU. In addition, 15 investigator-initiated institutional protocols were opened, 18 manuscripts were published and over 20 grants submitted with the assistance of the Biostatistics Core during this time. Over half of the effort provided by the Core (1862.5 hours (54%)) was for performing statistical analyses. An additional 589.5 hours (17%) were spent on grant development, 329 hours (10%) on protocol development, 570.5 hours (16%) on administration and clinical monitoring, and 110 hours (3%) on activities that bridged more than one category. Biostatisticians also provided 1.62 FTEs of effort on external peer-reviewed cancer-related grants as Principal Investigators and Co-investigators during the reported year. For the proposed grant period, we request 1.75 FTEs of statistical support, 0.25 FTEs of administrative support, and 0.20 FTEs of programming support to provide these continued services to Cancer Center members.

生物统计学核心（BIOC）的主要目标是促进成员的同行评审研究 Wake Forest大学（CCCWFU）综合癌症中心。我们负责 与临床，癌症控制和基础科学研究者合作，在解散的所有阶段 旨在减少癌症发生率并增加治疗选择的研究项目， 改善反应和生存，减少发病率，管理症状，改善与健康相关的生活质量， 并将重要的实验室发现转移到临床实践中。假定主要责任 方法论，统计和计算机相关问题，包括研究设计，抽样，统计方面 临床试验监测，临时审查和最终分析。具体来说，我们负责1）确保 该研究设计足够，2）编写所有治疗方案的统计部分，包括计划 对于试验结果的临时监测，3）开发用于III期临床试验的随机方案，4） 协助开发样品调查工具，5）监控正在进行的协议应计，6） 为CCCWFU研究者提供方法论支持，7）进行临时数据分析，8） 进行临时和最终分析，9）合作解释和发布结果，10）参与 在负责CCCWFU科学和行政方向的CCCWFU委员会中，11） 为CCCWFU成员进行有关研究方法的主题的每月研讨会系列，12） 定期统计援助计划会议，以协助赠款提交。 在2004年7月1日至2005年6月30日的报告中，BIOC提供了3,460小时的时间 支持与癌症相关的工作。 Bioc协助了来自所有计划的70名不同的研究人员， CCCWFU内的卓越中心。此外，15个调查员发起的机构方案是 开放，出版了18份手稿，并在生物统计学的协助下提交了20多个赠款 这段时间的核心。核心提供的一半以上（1862.5小时（54％））用于执行 统计分析。额外花了589.5小时（17％）用于赠款开发，329小时（10％） 协议开发，管理和临床监控为570.5小时（16％），在110小时（3％）上 桥接多个类别的活动。生物统计学家还为外部提供了1.62英尺的努力 在报告的一年中，与同行评审的癌症相关的赠款是首席研究人员和共同研究人员。 在拟议的赠款期间，我们要求1.75英尺的统计支持，0.25英尺的管理 支持和0.20英尺的编程支持，以向癌症中心提供这些继续的服务 成员。