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Translational models of neurodevelopmental epigenetics and disease using human iPSCs

Translational models of neurodevelopmental epigenetics and disease using human iPSCs
使用人类 iPSC 的神经发育表观遗传学和疾病的转化模型
批准号：
9324046
负责人：
Guo-li Ming
金额：
$25.01万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9324046
关键词：
AdultAlpha CellBiological ModelsBrainBrain regionCRISPR/Cas technologyCellsCytosineDNADNA MethylationDNA Modification ProcessData SetDevelopmentDiseaseEnzymesEpigenetic ProcessEventFunctional disorderGene Expression RegulationGenerationsGoalsGrowthHippocampal FormationHippocampus (Brain)HumanIn VitroIndividualLeadLearningLightMediatingMemoryModelingMolecularMusMutationNeuraxisNeurodegenerative DisordersNeurologicNeuronsOutcomePathologyPatientsPropertyProtein Binding DomainProtein FamilyProtocols documentationReaderRett SyndromeRoleSomatic CellStem cellsSynapsesSynaptic TransmissionSynaptic plasticityTechnologyTestingTetanus Helper PeptideTransplantationVariantautism spectrum disorderbiological adaptation to stresscell typedemethylationdentate gyrusepigenetic regulationepigenomein vivoinduced pluripotent stem cellinnovationlink proteinmood regulationnerve stem cellnervous system disorderneurodevelopmentneurogenesisneuron developmentneuropsychiatric disorderprotein functionsynaptogenesissynergismtechnology developmenttranscription factortranscriptomevirtual

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中文摘要
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英文摘要
PROJECT ABSTRACT – Project 3 N/A per PAR-14-183
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会议论文
Loss-of-Function Analyses of SETD1A in Human Neural Models
Loss-of-Function Analyses of SETD1A in Human Neural Models
Loss-of-Function Analyses of SETD1A in Human Neural Models
Engineering a human brain organoid-based platform to study neurotropic viruses
  • 批准号：
    9913453
  • 项目类别：
  • 资助金额：
    $151.19万
  • 财政年份：
    2017
  • 负责人：
    Guo-li Ming
  • 依托单位：
    UNIVERSITY OF PENNSYLVANIA
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