Infectious Disease and Basic Microbiological Mechanisms

描述（由申请人提供）：传染病和微生物学仍然是医疗保健研究中至关重要的领域。感染仍然是世界范围内死亡的主要原因，并在美国造成个人和公共卫生关注的严重问题。抗生素耐药性在所有类别的哺乳动物病原体中以惊人的速度和不断增加的速度发生。此外，曾经被认为在发达国家已接近根除的疾病，如肺结核、霍乱和风湿热，又以新的强度卷土重来。目前在其第36年，传染病和基本微生物学机制培训计划保持作为其主要目标的科学家谁有解决医学相关问题的职业目标，谁选择严格的实验室或流行病学培训的任何哈佛成人传染病计划或其他哈佛为基础的机构参与这一计划的培训。在过去的36年里，该计划成功地培养了学术医学和研究人员谁作出了重要贡献的领域的领导者。在这个竞争性的重新提交申请中，我们建议增加五年的资金，并将培训计划维持在目前每年8名博士后培训生的水平。我们将使用这些插槽直接提供支持选定的传染病医师研究员在指导研究，并提供支持选定的博士。哈佛医学院传染病和微生物学实验室的受训人员专注于具有重要临床相关性的领域，以支持这些实验室内的医生-科学家丰富的研究-培训环境，并提供这些博士学位。受训者密集接触受过医学训练的临床研究人员。培训将包括至少两年的指导研究，并进行实验室内的实践培训，适当的高级非学位授予研究生课程，学员出席和参加与传染病和微生物学研究直接相关的定期会议和研讨会，并指导编写有竞争力的供资提案，特别强调K和其他职业发展奖项的申请，包括基金会奖项。该培训计划的具体目标如下：1。在基本的实验室或流行病学技术和方法方面获得足够的培训，以便对相关的传染病问题进行有效的前沿研究;通过项目教师强有力的纵向指导来促进重要科学贡献的创造; 3.发展主要的研究重点和对传染病和微生物学的广泛理解，以便能够进行新的跨学科研究并导致独立。

DESCRIPTION (provided by applicant): Infectious diseases and microbiology continue to be areas of pivotal importance in health care research. Infection remains a major cause of mortality worldwide and poses serious problems of both individual and public health concern in the United States. Antibiotic resistance occurs at an alarming and increasing rate among all classes of mammalian pathogens. Moreover, diseases once thought to be near eradication from the developed world-for example, tuberculosis, cholera, and rheumatic fever-have rebounded with renewed intensity. Currently in its 36th year, the Infectious Disease and Basic Microbiological Mechanisms training program maintains as its primary goal the training of scientists who have a career goal of solving medically relevant problems and who elect rigorous laboratory or epidemiologic training in any of the Harvard adult infectious disease programs or other Harvard-based institutions participating in this program. Over the past 36 years, the program has successfully trained leaders in academic medicine and investigators who have made important contributions to the field. In this competing resubmission application, we propose an additional five years of funding and to maintain the training program at its current level of eight postdoctoral trainees slots per year. We will use these slots to provide support directly to selected infectious disease physician fellows during mentored research, and to also provide support to selected Ph.D. trainees in Harvard Medical School infectious disease and microbiology laboratories focused on areas that have significant clinical relevance, so as to support the rich research- training environment for physician-scientists within these laboratories and to provide these Ph.D. trainees intensive exposure to medically-trained clinically-active researchers. Training will include a minimum of two years of mentored research with hands-on in-laboratory training, appropriate advanced non-degree-granting post-graduate coursework, attendance and participation of trainees at regular meetings and seminars of direct relevance to infectious disease and microbiology research, and instruction in the preparation of competitive proposals for funding, with a particular emphasis on applications for K and other career development awards, including foundation awards. The specific aims of this training program are as follows: 1. To acquire sufficient training in basic laboratory or epidemiologic techniques and approaches to conduct effective leading edge research into relevant infectious disease problems; 2. To foster the creation of important scientific contributions by means of strong and longitudinal mentorship by program faculty; and 3. To develop a primary research focus and a broad understanding of infectious diseases and microbiology, so as to both enable novel interdisciplinary research and lead to independence.