Infectious Disease and Basic Microbiological Mechanisms

描述（由申请人提供）：传染病和微生物学仍然是卫生保健研究中至关重要的领域。感染仍然是世界范围内导致死亡的一个主要原因，在美国对个人和公共卫生都构成了严重的问题。在所有种类的哺乳动物病原体中，抗生素耐药性正以惊人的速度不断增加。此外，曾经被认为在发达国家几乎被消灭的疾病，如肺结核、霍乱和风湿热，已经卷土重来。目前已经是第36个年头了，传染病和基本微生物机制培训项目的主要目标是培养以解决医学相关问题为职业目标的科学家，并在任何哈佛成人传染病项目或参与该项目的其他哈佛机构中选择严格的实验室或流行病学培训。在过去的36年里，该计划成功地培养了学术医学的领导者和研究人员，他们对该领域做出了重要贡献。在这个竞争性的重新提交申请中，我们建议再提供五年的资金，并将培训计划保持在目前每年8个博士后培训名额的水平。我们将利用这些名额直接支持在指导研究期间选定的传染病医师研究员，并为选定的哈佛医学院传染病和微生物学实验室的博士生提供支持，这些博士生专注于具有重要临床相关性的领域。以便在这些实验室中为医生科学家提供丰富的研究培训环境，并为这些博士学员提供与受过医学训练的临床活跃研究人员的密切接触。培训将包括至少两年的实验室实践指导研究、适当的不授予学位的高级研究生课程、受训者出席和参与与传染病和微生物学研究直接相关的定期会议和研讨会、指导编制竞争性供资提案，特别强调申请K奖和其他职业发展奖。包括基金会的奖励。本次培训计划的具体目的如下：1、培训内容：在基本的实验室或流行病学技术和方法方面获得足够的培训，以便对相关传染病问题进行有效的前沿研究；2. 通过项目教师强有力的纵向指导，促进重要科学贡献的创造；和3。建立一个主要的研究重点和对传染病和微生物学的广泛理解，以便进行新的跨学科研究并导致独立。

DESCRIPTION (provided by applicant): Infectious diseases and microbiology continue to be areas of pivotal importance in health care research. Infection remains a major cause of mortality worldwide and poses serious problems of both individual and public health concern in the United States. Antibiotic resistance occurs at an alarming and increasing rate among all classes of mammalian pathogens. Moreover, diseases once thought to be near eradication from the developed world-for example, tuberculosis, cholera, and rheumatic fever-have rebounded with renewed intensity. Currently in its 36th year, the Infectious Disease and Basic Microbiological Mechanisms training program maintains as its primary goal the training of scientists who have a career goal of solving medically relevant problems and who elect rigorous laboratory or epidemiologic training in any of the Harvard adult infectious disease programs or other Harvard-based institutions participating in this program. Over the past 36 years, the program has successfully trained leaders in academic medicine and investigators who have made important contributions to the field. In this competing resubmission application, we propose an additional five years of funding and to maintain the training program at its current level of eight postdoctoral trainees slots per year. We will use these slots to provide support directly to selected infectious disease physician fellows during mentored research, and to also provide support to selected Ph.D. trainees in Harvard Medical School infectious disease and microbiology laboratories focused on areas that have significant clinical relevance, so as to support the rich research- training environment for physician-scientists within these laboratories and to provide these Ph.D. trainees intensive exposure to medically-trained clinically-active researchers. Training will include a minimum of two years of mentored research with hands-on in-laboratory training, appropriate advanced non-degree-granting post-graduate coursework, attendance and participation of trainees at regular meetings and seminars of direct relevance to infectious disease and microbiology research, and instruction in the preparation of competitive proposals for funding, with a particular emphasis on applications for K and other career development awards, including foundation awards. The specific aims of this training program are as follows: 1. To acquire sufficient training in basic laboratory or epidemiologic techniques and approaches to conduct effective leading edge research into relevant infectious disease problems; 2. To foster the creation of important scientific contributions by means of strong and longitudinal mentorship by program faculty; and 3. To develop a primary research focus and a broad understanding of infectious diseases and microbiology, so as to both enable novel interdisciplinary research and lead to independence.