2/2 Collaboration to Establish the Prevalence and Characteristics of FASD in U.S. Communities: Continuation of the CoFASP Initiative

摘要 胎儿酒精谱系障碍患病率合作倡议由以下机构发起： NIAAA在2010年建立了合理的，可重复的和可推广的患病率估计， 胎儿酒精谱系障碍（FASD）的特征在定义的区域社区的美国。 有了这个建议，胎儿酒精流行病学研究（FASER）小组的研究人员，从协调 位于查佩尔山的北卡罗来纳州大学将继续与该大学的调查人员合作 的加州，圣地亚哥（UCSD）和NIAAA顾问完成CoFASP的具体目标。我们将 合作生产新RFA AA-16-007中要求的特定产品。根据持续的具体目标， FASER的合作者将实现以下两个目标：1.）使用商定的标准， CoFASP参与者2012-2015，我们将完成所有样本数据，分析，并共同撰写的手稿， FASD的患病率和特征以及FASD的母亲危险因素。数据来自9 FASER团队从三个不同州的五个不同社区收集的独立样本， 美国.我们将提供所有的数据到UCSD数据分析协调单位（DACU）的未来 分析和出版物。2.）我们将完成：a.）母亲营养的详细研究样本， FASER研究点的营养数据系统（NDSR）和B.）人体测量研究和生长 解剖学特征曲线对准确诊断儿童出生时FASD连续体至关重要- 18 年龄，并将数据提供给DACU。3.）第三章为了实现新的RFA驱动的具体目标，我们将：a. 合作提供时间轴和研究方案纲要，用于计算每个阶段的患病率估计值 位点; B.）完成一份共同撰写的手稿，详细介绍了最终的采样，诊断，和强大的，分析 在一般人群中确定准确、透明、基于地点的流行率的方法; c.） 提供其他FASD诊断标准和方法（例如ICD-10，加拿大系统， ND-PAE和临床判断）影响FASD的诊断和患病率， 与CoFASP研究中产生的经验数据最接近; d.）明确增长的贡献 对FAS和其他FASD进行制造;以及e.）合作有效完成和传播成果 通过多个，参考出版物和演示文稿。

ABSTRACT The Collaboration of Fetal Alcohol Spectrum Disorders Prevalence (CoFASP) initiative was launched by NIAAA in 2010 to establish reasonable, reproducible, and generalizable estimates of the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) within defined regional communities of the USA. With this proposal, the Fetal Alcohol Epidemiology Research (FASER) Team investigators, coordinated from the University of North Carolina, Chapel Hill, will continue to collaborate with investigators from the University of California, San Diego (UCSD) and NIAAA advisors to complete the specific aims of CoFASP. We will collaborate and produce specific products called for in the new RFA AA-16-007. Under continuing specific aims of CoFASP, FASER collaborators will accomplish the following two aims: 1.) Using criteria agreed upon by CoFASP participants 2012-2015, we will complete all sample data, analyses, and co-authored manuscripts on the prevalence and characteristics of FASD and maternal risk factors for FASD. The data come from nine independent samples collected by the FASER Team from five different communities in three different states of the USA. We will deliver all of the data to the UCSD Data Analysis Coordination Unit (DACU) for future analyses and publications. 2.) We will complete: a.) the detailed study samples of maternal nutrition with the Nutrition Data System for Research (NDSR) at FASER sites and b.) the anthropometric study and growth curves of anatomical features essential to the accurate diagnosis of the FASD continuum in children birth - 18 years of age and provide the data to the DACU. 3.) To accomplish new RFA-driven specific aims, we will: a.) collaborate to deliver a timeline and outline of study protocols used to calculate prevalence estimates at each site; b.) complete a co-authored manuscript detailing the final sampling, diagnostic, and robust, analytic methodology for establishing accurate, transparent, site-based prevalence rates in a general population; c.) provide comparisons of how other FASD diagnostic criteria and approaches (e.g. ICD-10, Canadian system, ND-PAE, and clinical judgement) affect diagnosis and prevalence rates of FASD and which approaches mesh most closely with the empirical data generated in the CoFASP studies; d.) clarify the contribution that growth makes to FAS and other FASD; and e.) collaborate for effective completion and dissemination of results through multiple, refereed publications and presentations.