2/2 Collaboration to Establish the Prevalence and Characteristics of FASD in U.S. Communities: Continuation of the CoFASP Initiative

摘要 胎儿酒精谱系疾病患病率合作倡议由 NIAAA在2010年建立了合理的、可重复的和可推广的流行率和普遍性估计 美国确定的区域社区内胎儿酒精谱系障碍(FASD)的特征。 有了这项建议，胎儿酒精流行病学研究(FASER)小组的调查人员，从 北卡罗来纳大学教堂山分校将继续与该大学的调查人员合作 加州大学圣地亚哥分校(UCSD)和NIAAA顾问完成了COFASP的具体目标。我们会 协作生产新的RFA AA-16-007中要求的特定产品。在持续的具体目标下 在CoFASP中，Faser合作者将实现以下两个目标：1)使用由以下各方商定的标准 COFASP参与者2012-2015年，我们将完成所有样本数据、分析和共同撰写的手稿 胎儿自闭症的患病率、特点及母体危险因素这些数据来自九个国家 Faser团队从三个不同州的五个不同社区收集的独立样本 美国。我们将把所有数据提交给加州大学圣地亚哥分校数据分析协调股(DACU)以供将来使用 分析和出版物。2.)我们将完成：a.)孕妇营养状况的详细研究样本 Faser站点和b.的营养研究数据系统(NDSR)人体测量学研究与生长 对18岁以下儿童FASD连续体进行准确诊断所必需的解剖特征曲线 年龄，并将数据提供给DACU。3.)为了实现新的由RFA驱动的具体目标，我们将：a. 协作提供时间表和研究方案大纲，用于计算每个项目的患病率估计 站点；b.)完成一份共同撰写的手稿，详细说明最终采样、诊断和稳健的分析 C.在普通人群中确定准确、透明、以现场为基础的流行率的方法；c.) 提供其他FASD诊断标准和方法(例如ICD-10、加拿大系统、 ND-PAE和临床判断)影响FASD的诊断和患病率，并接近MESH 与COFASP研究中产生的经验数据最为接近；d.明确增长的贡献 对FASD和其他FASD；以及e.)为有效完成和传播成果而合作 通过多个被引用的出版物和演示文稿。

ABSTRACT The Collaboration of Fetal Alcohol Spectrum Disorders Prevalence (CoFASP) initiative was launched by NIAAA in 2010 to establish reasonable, reproducible, and generalizable estimates of the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) within defined regional communities of the USA. With this proposal, the Fetal Alcohol Epidemiology Research (FASER) Team investigators, coordinated from the University of North Carolina, Chapel Hill, will continue to collaborate with investigators from the University of California, San Diego (UCSD) and NIAAA advisors to complete the specific aims of CoFASP. We will collaborate and produce specific products called for in the new RFA AA-16-007. Under continuing specific aims of CoFASP, FASER collaborators will accomplish the following two aims: 1.) Using criteria agreed upon by CoFASP participants 2012-2015, we will complete all sample data, analyses, and co-authored manuscripts on the prevalence and characteristics of FASD and maternal risk factors for FASD. The data come from nine independent samples collected by the FASER Team from five different communities in three different states of the USA. We will deliver all of the data to the UCSD Data Analysis Coordination Unit (DACU) for future analyses and publications. 2.) We will complete: a.) the detailed study samples of maternal nutrition with the Nutrition Data System for Research (NDSR) at FASER sites and b.) the anthropometric study and growth curves of anatomical features essential to the accurate diagnosis of the FASD continuum in children birth - 18 years of age and provide the data to the DACU. 3.) To accomplish new RFA-driven specific aims, we will: a.) collaborate to deliver a timeline and outline of study protocols used to calculate prevalence estimates at each site; b.) complete a co-authored manuscript detailing the final sampling, diagnostic, and robust, analytic methodology for establishing accurate, transparent, site-based prevalence rates in a general population; c.) provide comparisons of how other FASD diagnostic criteria and approaches (e.g. ICD-10, Canadian system, ND-PAE, and clinical judgement) affect diagnosis and prevalence rates of FASD and which approaches mesh most closely with the empirical data generated in the CoFASP studies; d.) clarify the contribution that growth makes to FAS and other FASD; and e.) collaborate for effective completion and dissemination of results through multiple, refereed publications and presentations.