Cancer-Translational Nanotechnology Training Program (Cancer-TNT)

 描述(申请人提供)：拟议的博士后培训计划，癌症-翻译纳米技术培训(癌症-TNT)计划，是一个多样化和协同的3年期培训计划，汇集了来自三所学校的25名教员和9个系，以培训下一代跨学科领导者，他们将在癌症研究和临床翻译方面面临挑战。癌症纳米技术是一个快速发展的领域，需要来自不同科学领域的研究人员密切互动，如化学、材料科学、癌症生物学和医学。在拟议的5年周期内，我们将招聘12名博士后学员，为他们提供教育和跨学科培训，以培养癌症纳米技术翻译方面的跨学科研究人员。八(8)名学员将在5年周期内完成培训。我们受训人员的技能组合将连接多个学科，如化学、分子生物学、生物工程、分子成像、纳米工程和临床癌症医学。受训人员将能够推进癌症研究、诊断和管理。来自医学方面的斯坦福大学分子成像计划(MIPS)，以及来自工程方面的化学、材料科学和工程系，将为我们的计划提供坚实的基础。斯坦福大学的环境还领导着一个富有成效的癌症纳米技术卓越中心(CCNE-T)、国家癌症研究所指定的综合癌症中心(NCI)、活体细胞和分子成像中心(ICMIC@Stanford)、高效的跨学科Bio-X计划、纳米制造和纳米表征设施以及纳米信息学能力、金丝雀癌症早期检测中心和物理科学肿瘤学中心(PSOC)，其中我们的几位导师在其中发挥了主导作用。通过这些活动，我们已经成功地培训了下一代癌症纳米技术专家，我们对通过癌症-TNT正式开展和扩大培训活动的可能性感到兴奋。我们的计划包括代表五个计划领域的不同的教师导师小组。通过这个导师小组，我们能够将癌症生物学、癌症免疫学、分子成像、分子药理学和基因治疗、纳米医学、微/纳米制造、生物芯片、电气工程和材料科学；纳米表征方面的实践培训活动；以及包括斯坦福肿瘤学临床讲座系列在内的临床组成部分整合在一起。癌症-TNT研究员将被招募到一个为期3年的项目中，在两名互补导师的指导下完成课程和研究。学员将在第二年准备模拟助学金提案，以帮助他们在助学金申请过程中获得经验和信心。培训委员会将监督学员的进展，咨询委员会将监督整个计划。在NCI的支持下，斯坦福大学准备成为快速增长的癌症纳米技术领域的主要培训中心。

 DESCRIPTION (provided by applicant): The proposed postdoctoral training program, Cancer-Translational Nanotechnology Training (Cancer-TNT) Program, is a diverse and synergistic 3-year training program bringing together 25 faculty and 9 Departments from three schools to train the next generation of interdisciplinary leaders who will pursue challenges in cancer research and clinical translation. Cancer nanotechnology is a rapidly growing field that requires close interactions of researchers from disparate fields of science, such as chemistry, materials science, cancer biology, and medicine. During the proposed 5-year cycle, we will recruit a total of 12 postdoctoral trainees to provide them with education and cross-disciplinary training to develop interdisciplinary researchers in cancer nanotechnology translation. Eight (8) trainees will complete training during the 5-year cycle. Our trainees' skill sets will bridge multiple disciplines such as chemistry, molecular biology, bioengineering, molecular imaging, nanoengineering, and clinical cancer medicine. Trainees will be able to advance cancer research, diagnosis, and management. The Molecular Imaging Program at Stanford (MIPS) from the medicine side, with the Departments of Chemistry, Materials Science and Engineering from the engineering side, will provide a solid foundation for our program. The Stanford environment also leads a productive Center for Cancer Nanotechnology Excellence (CCNE-T), an NCI Designated Comprehensive Cancer Center, an In Vivo Cellular and Molecular Imaging Center (ICMIC @ Stanford), the highly effective interdisciplinary Bio-X program, facilities for Nanofabrication and Nanocharacterization, as well as Nanoinformatics capabilities, the Canary Center for Cancer Early Detection, and a Physical Sciences Oncology Center (PSOC), in which several of our mentors have leading roles. Through these activities, we have already been successfully training the next generation of cancer nanotechnologists and we are excited by the possibility to formalize and expand training activities through the Cancer-TNT. Our program includes a diverse group of faculty mentors representing five program areas. Through this mentor group, we are able to bring together formal courses in cancer biology, cancer immunology, molecular imaging, molecular pharmacology, and gene therapy, nanomedicine, micro/nanofabrication, biochips, electrical engineering, and materials science; hands-on training activities in Nanocharacterization; and a clinical component including Stanford Oncology Clinical Lecture Series. The Cancer-TNT fellows will be recruited into a 3-year program to complete coursework and research with two complementary mentors. Trainees will prepare a mock grant proposal in their second year to help them gain experience and confidence in the grant application process. A Training Committee will oversee trainee progress, with an Advisory Committee monitoring the entire program. Stanford University, with support from the NCI, is poised to be a major training center for the rapidly growing field of cancer nanotechnology.