Cancer-Translational Nanotechnology Training Program (Cancer-TNT)

 描述（由申请人提供）：拟议的博士后培训计划，癌症转化纳米技术培训（癌症-TNT）计划，是一个多样化和协同的3年培训计划，汇集了来自三所学校的25名教师和9个部门，以培养下一代跨学科领导者，他们将追求癌症研究和临床翻译的挑战。癌症纳米技术是一个快速发展的领域，需要来自不同科学领域的研究人员的密切互动，如化学，材料科学，癌症生物学和医学。在拟议的5年周期内，我们将招募共12名博士后学员，为他们提供教育和跨学科培训，以培养癌症纳米技术翻译的跨学科研究人员。八（8）名受训人员将在五年周期内完成培训。我们的学员的技能将跨越多个学科，如化学，分子生物学，生物工程，分子成像，纳米工程和临床癌症医学。学员将能够推进癌症研究，诊断和管理。斯坦福大学（MIPS）的分子成像项目将为我们的项目提供坚实的基础。斯坦福大学的环境还导致了一个生产中心的癌症纳米技术卓越（CCNE-T），NCI指定的综合癌症中心，在体内细胞和分子成像中心（ICMIC @斯坦福大学），高效的跨学科Bio-X计划，纳米结构和纳米表征设施，以及纳米信息学能力，金丝雀癌症早期检测中心，和物理科学肿瘤中心（PSOC），其中我们的几位导师担任领导角色。通过这些活动，我们已经成功地培训了下一代癌症纳米技术专家，我们对通过Cancer-TNT正式化和扩大培训活动的可能性感到兴奋。我们的计划包括代表五个计划领域的教师导师的多元化群体。通过这个导师小组，我们能够汇集癌症生物学，癌症免疫学，分子成像，分子药理学和基因治疗，纳米医学，微/纳米纤维，生物芯片，电气工程和材料科学的正式课程;纳米表征的实践培训活动;和临床部分，包括斯坦福大学肿瘤学临床讲座系列。癌症TNT研究员将被招募到一个为期3年的计划，完成课程和研究与两个互补的导师。学员将在第二年准备一份模拟赠款提案，以帮助他们获得赠款申请过程中的经验和信心。培训委员会将监督学员的进展，咨询委员会将监督整个计划。斯坦福大学在NCI的支持下，准备成为快速发展的癌症纳米技术领域的主要培训中心。

 DESCRIPTION (provided by applicant): The proposed postdoctoral training program, Cancer-Translational Nanotechnology Training (Cancer-TNT) Program, is a diverse and synergistic 3-year training program bringing together 25 faculty and 9 Departments from three schools to train the next generation of interdisciplinary leaders who will pursue challenges in cancer research and clinical translation. Cancer nanotechnology is a rapidly growing field that requires close interactions of researchers from disparate fields of science, such as chemistry, materials science, cancer biology, and medicine. During the proposed 5-year cycle, we will recruit a total of 12 postdoctoral trainees to provide them with education and cross-disciplinary training to develop interdisciplinary researchers in cancer nanotechnology translation. Eight (8) trainees will complete training during the 5-year cycle. Our trainees' skill sets will bridge multiple disciplines such as chemistry, molecular biology, bioengineering, molecular imaging, nanoengineering, and clinical cancer medicine. Trainees will be able to advance cancer research, diagnosis, and management. The Molecular Imaging Program at Stanford (MIPS) from the medicine side, with the Departments of Chemistry, Materials Science and Engineering from the engineering side, will provide a solid foundation for our program. The Stanford environment also leads a productive Center for Cancer Nanotechnology Excellence (CCNE-T), an NCI Designated Comprehensive Cancer Center, an In Vivo Cellular and Molecular Imaging Center (ICMIC @ Stanford), the highly effective interdisciplinary Bio-X program, facilities for Nanofabrication and Nanocharacterization, as well as Nanoinformatics capabilities, the Canary Center for Cancer Early Detection, and a Physical Sciences Oncology Center (PSOC), in which several of our mentors have leading roles. Through these activities, we have already been successfully training the next generation of cancer nanotechnologists and we are excited by the possibility to formalize and expand training activities through the Cancer-TNT. Our program includes a diverse group of faculty mentors representing five program areas. Through this mentor group, we are able to bring together formal courses in cancer biology, cancer immunology, molecular imaging, molecular pharmacology, and gene therapy, nanomedicine, micro/nanofabrication, biochips, electrical engineering, and materials science; hands-on training activities in Nanocharacterization; and a clinical component including Stanford Oncology Clinical Lecture Series. The Cancer-TNT fellows will be recruited into a 3-year program to complete coursework and research with two complementary mentors. Trainees will prepare a mock grant proposal in their second year to help them gain experience and confidence in the grant application process. A Training Committee will oversee trainee progress, with an Advisory Committee monitoring the entire program. Stanford University, with support from the NCI, is poised to be a major training center for the rapidly growing field of cancer nanotechnology.