Elucidating the role of cognitive and physiological aspects of affect in alcohol use relapse

阐明认知和生理方面的影响在酗酒复发中的作用

• 批准号: 9188860
• 负责人: DAVID EDDIE
• 金额: $ 5.7万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2018-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9188860
• 关键词: Address; Adult; Affect; Affective; Alcohol consumption; Ambulatory Monitoring; Anxiety; Area; Autonomic nervous system; Awareness; Behavioral; Biological; Biological Markers; Brain; Clinical; Cognitive; Complement; Conscious; Cues; Data; Development; Disease; Disease remission; Ecological momentary assessment; Environment; Event; Fellowship; Future; Goals; Health Services Accessibility; In Situ; Individual; Intervention; Investigation; Knowledge; Lead; Measurement; Measures; Mediating; Mental disorders; Methods; Modality; Modeling; Monitor; Moods; Neurologic; Outpatients; Participant; Patient Self-Report; Patients; Pattern; Physiological; Principal Investigator; Process; Psychophysiology; Recovery; Regulation; Relapse; Reporting; Research; Research Methodology; Research Technics; Risk; Role; Sampling; Signal Transduction; Substance Use Disorder; System; Techniques; Testing; Time; Training; Work; abstracting; addiction; alcohol abstinence; alcohol abuse therapy; alcohol relapse; alcohol use disorder; base; biobehavior; clinical care; cost; craving; design; follow-up; improved; indexing; negative mood; novel; programs; psychologic; psychosocial; relapse prediction; relapse risk; skills; stem; stressor; treatment program

R&R7. Project Summary/Abstract There is a pressing need to better understand specific factors that lead to relapse among individuals seeking treatment for alcohol use disorder (AUD) in order to improve existing treatments and develop new interventions for this pervasive and costly disorder. While psychological and affective factors have been investigated as predictors of relapse, little is currently known about physiological markers of relapse risk, and most existing research has not taken advantage of newer real-time psychological assessment methods. This investigation is novel in that it will study simultaneously, cognitive factors associated with alcohol relapse such as anxiety and craving, and associated autonomic nervous system processes as they occur in the environment, in order to identify psychological and biological vulnerabilities that may heighten relapse risk for AUD. The study's goal to identify patterns of real-time affect and patterns of affective lability that predict relapse, as well as attendant biomarkers of affect regulation that operate outside of conscious awareness, and thus may add important, objective information about affective regulation that can complement self-report measures in the study of AUD. Further, the training plan outlined in this fellowship will provide the principal investigator with an important set of skills that will grow his capacity to conduct cutting edge research in the areas of substance use disorders (SUDs) and other mental disorders characterized by affect dysregulation. This will be achieved through specialized training in ecological momentary assessment (EMA), a powerful research modality for studying affective and behavioral processes in real time, as individuals interact with their environment. The long-term goal of this program of research and the attendant training plan is to develop integrated biobehavioral treatments for alcohol and other SUDs that address individual vulnerabilities that can undermine individuals' attempts to achieve lasting remission. This study will provide valuable information about the utility and feasibility of applying novel assessment techniques like EMA and ambulatory psychophysiological assessment to the study of addictive disorders, which has the potential to open up new avenues of research.

R&R7.项目总结/摘要 迫切需要更好地了解导致寻求庇护者复发的具体因素。 酒精使用障碍（AUD）的治疗，以改善现有的治疗和开发新的干预措施 治疗这种普遍而昂贵的疾病虽然心理和情感因素已被调查， 复发的预测因子，目前对复发风险的生理标志物知之甚少，大多数现有的 研究没有利用更新的实时心理评估方法。这项调查是 新颖之处在于，它将同时研究与酒精复发相关的认知因素，如焦虑， 渴望和相关的自主神经系统过程，因为它们发生在环境中，以 识别可能增加AUD复发风险的心理和生物脆弱性。该研究的目标是 识别预测复发的实时情感模式和情感不稳定模式，以及伴随的 影响调节的生物标志物在意识意识之外运作，因此可能增加重要的， 情感调节的客观信息可以补充AUD研究中的自我报告措施。 此外，本研究金中概述的培训计划将为主要研究者提供一套重要的 这些技能将提高他在物质使用障碍领域进行尖端研究的能力 （SUD）和其他以情感失调为特征的精神障碍。完成这项工作的方法是 在生态瞬时评估（EMA）的专业培训，一个强大的研究模式，研究 情感和行为过程在真实的时间，作为个人与他们的环境相互作用。长期 这项研究计划的目标和随之而来的培训计划是开发综合生物行为 针对酒精和其他SUD的治疗，解决可能破坏个人健康的个人脆弱性。 努力实现持久缓解。这项研究将提供有价值的信息， 应用新型评估技术（如EMA和动态心理生理评估）的可行性 成瘾性疾病的研究，这有可能开辟新的研究途径。