Alliance for Regenerative Rehabilitation Research & Training (AR3T)

 描述(由申请人提供)：再生医学原理和技术的进步具有巨大的潜力，可以推动在预防和治疗因损伤、疾病或衰老而导致的各种病理疾病方面取得进展。再生医学的长期目标是促进组织的修复、替代或再生。同样，康复寻求利用身体与生俱来的再生潜力，以最大限度地发挥功能。这两个领域都具有巨大的潜力，可以推动在治疗一系列 急性和慢性的病理学。我们认为这两个领域是密不可分地交织在一起的；这两个学科的交叉被称为再生康复。为了充分发挥再生康复的巨大潜力，我们必须促进基础科学家与康复专家的互动。我们还必须培训康复临床医生，他们可以帮助监督这些创新的再生康复技术的质量、安全性和有效性。再生康复研究与培训联盟(AR3T)的首要目标是建立一个全国性的网络，将科学知识、专业知识和方法扩展到再生医学和康复领域。AR3T将提供教学培训，使康复研究人员接触到再生医学领域的尖端研究和最先进的技术(具体目标1)。AR3T将 通过以下方式推动再生康复的科学基础：在再生医学领域培养康复研究人员和国际知名研究人员之间的合作机会(特定目标2)；启动一项试点资助计划，以支持再生康复研究的新思路(特定目标3)；开发和验证技术，以阐明干细胞对外部机械信号的反应(特定目标4)。如具体目标5所述，认真监测和评估我们方案的有效性，将确保这些目标取得尽可能大的成功。这五个目标已经被组织起来，以便与P2C赠款提案的每一个组成部分相平行。

 DESCRIPTION (provided by applicant): The advancement of regenerative medicine principles and technologies holds great potential to drive progress in the prevention and treatment of individuals with a host of pathologies resulting from injury, disease or aging. The long-term goal of regenerative medicine is to promote the repair, replacement, or regeneration of tissues. Likewise, rehabilitation seeks to harness the body's innate regenerative potential in order to maximize function. Both fields hold great potential to drive progress in the treatment of a host of acute and chronic pathologies. We propose that these two fields are inextricably intertwined; an intersection of disciplines known as Regenerative Rehabilitation. To fully realize the tremendous potential of Regenerative Rehabilitation, we must promote the interaction of basic scientists with rehabilitation specialists. We must also train rehabilitation clinicians who can help oversee the quality, safety, and validity of these innovative Regenerative Rehabilitation technologies. The overarching goal of the Alliance for Regenerative Rehabilitation Research & Training (AR3T) is to establish a national network that will expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. AR3T will provide didactic training that exposes rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Specific Aim 1). AR3T will drive the science underlying Regenerative Rehabilitation by: cultivating collaborative opportunities among rehabilitation researchers and internationally renowned investigators in the field of regenerative medicine (Specific Aim 2); launching a pilot funding program to support novel lines of Regenerative Rehabilitation investigations (Specific Aim 3); developing and validating technologies to elucidate the stem cell response to extrinsic mechanical signals (Specific Aim 4). Careful monitoring and evaluation of the effectiveness of our program, as outlined in Specific Aim 5, will ensure that these aims achieve the greatest success possible. These five aims have been organized to parallel each of the P2C grant proposal components.