Alliance for Regenerative Rehabilitation Research & Training (AR3T)

再生康复研究联盟

• 批准号: 9145751
• 负责人: MICHAEL L. BONINGER
• 金额: $ 107.12万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-17 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9145751
• 关键词: Accountability; Activities of Daily Living; Acute; Age; Aging; Animal Model; Applications Grants; Basic Science; Biological Markers; Biological Models; Chronic; Clinical; Collaborations; Communities; Congenital Abnormality; Country; Data Analyses; Development; Disabled Persons; Discipline; Disease; Documentation; E-learning; Effectiveness; Ensure; Evaluation; Fostering; Foundations; Funding; Future; Goals; Health; Home environment; In Vitro; Incubators; Individual; Injury; Institutes; Institution; Intervention; Investigation; Knowledge; Laboratories; Life; Measurement; Mechanical Stimulation; Mechanics; Methodology; Methods; Monitor; Muscle satellite cell; Organ; Pathology; Performance; Physical Function; Physical Medicine; Physical activity; Physiological; Prevention; Process; Protocols documentation; Recommendation; Regenerative Medicine; Rehabilitation Research; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Training; Resources; Safety; Science; Scientist; Series; Signal Transduction; Skeletal Muscle; Specialist; Stem cells; Stimulus; Structure; Technology; Tissue Engineering; Tissues; Training; Translating; Trauma; Work; bioluminescence imaging; career; cell behavior; design; falls; frontier; improved; in vivo; innovation; interest; massive open online courses; mode of exercise; multidisciplinary; novel; operation; programs; regenerative; regenerative therapy; rehabilitation science; rehabilitation technology; repaired; response; restoration; sabbatical; stem cell therapy; success; symposium; therapy design; tissue regeneration; tissue repair; tool; webinar

 DESCRIPTION (provided by applicant): The advancement of regenerative medicine principles and technologies holds great potential to drive progress in the prevention and treatment of individuals with a host of pathologies resulting from injury, disease or aging. The long-term goal of regenerative medicine is to promote the repair, replacement, or regeneration of tissues. Likewise, rehabilitation seeks to harness the body's innate regenerative potential in order to maximize function. Both fields hold great potential to drive progress in the treatment of a host of acute and chronic pathologies. We propose that these two fields are inextricably intertwined; an intersection of disciplines known as Regenerative Rehabilitation. To fully realize the tremendous potential of Regenerative Rehabilitation, we must promote the interaction of basic scientists with rehabilitation specialists. We must also train rehabilitation clinicians who can help oversee the quality, safety, and validity of these innovative Regenerative Rehabilitation technologies. The overarching goal of the Alliance for Regenerative Rehabilitation Research & Training (AR3T) is to establish a national network that will expand scientific knowledge, expertise and methodologies across the domains of regenerative medicine and rehabilitation. AR3T will provide didactic training that exposes rehabilitation researchers to cutting-edge investigations and state-of-the-art technologies in the field of regenerative medicine (Specific Aim 1). AR3T will drive the science underlying Regenerative Rehabilitation by: cultivating collaborative opportunities among rehabilitation researchers and internationally renowned investigators in the field of regenerative medicine (Specific Aim 2); launching a pilot funding program to support novel lines of Regenerative Rehabilitation investigations (Specific Aim 3); developing and validating technologies to elucidate the stem cell response to extrinsic mechanical signals (Specific Aim 4). Careful monitoring and evaluation of the effectiveness of our program, as outlined in Specific Aim 5, will ensure that these aims achieve the greatest success possible. These five aims have been organized to parallel each of the P2C grant proposal components.