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Alzheimer's Disease Viewed as a Neurovascular Inflammatory Disorder

阿尔茨海默病被视为一种神经血管炎症性疾病

基本信息

批准号：
9195011
负责人：
Costantino Iadecola
金额：
$ 1.5万
依托单位：
NEW YORK ACADEMY OF SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2017-12-05
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9195011
关键词：
Academia Academy Address Age Alzheimer&apos s Disease Amyloid Animal Model Area Awards and Prizes Basic Science Biological Markers Biology Blood - brain barrier anatomy Blood Vessels Brain Cerebral Amyloid Angiopathy Cerebrovascular Disorders Child Care Clinical Clinical Sciences Clinical Trials Collaborations Communication Communities Data Dementia Developing Countries Development Disabled Persons Disease Disease Progression Ensure Environment Etiology Event Faculty Family Fellowship Female Fostering Foundations Functional disorder Future Genetic Goals Government Head Health Healthcare Systems Human Image Immune response Impaired cognition Impairment Industry Inflammation Inflammatory International Knowledge Label Life Link Maps Medical Research Microvascular Dysfunction Molecular Molecular Target Monitor National Institute of Neurological Disorders and Stroke Neurodegenerative Disorders Neurons New York Nonprofit Organizations Onset of illness Oral Participant Pathology Patients Persons Physiological Processes Population Prevention Prize Process Publications Publishing Research Research Personnel Risk Factors Role Science Stroke Study models Technology Testing Translating Translations Travel Underrepresented Minority Update Vascular Dementia Vascular Diseases Woman Work abstracting aging population base biomarker identification career data exchange discount effective therapy genetic information global health health economics improved insight interdisciplinary approach knowledge base meetings minority investigator neuropathology neurovascular new therapeutic target novel patient population posters pre-clinical prevent racial minority repository socioeconomics symposium therapeutic target tool vascular contributions vascular inflammation webinar

项目摘要

Alzheimer’s Disease Viewed as a Neurovascular Inflammatory Disorder PROJECT SUMMARY / ABSTRACT Alzheimer’s disease (AD) is a devastating neurodegenerative disorder lacking effective treatments. Most clinical trials testing the long-standing amyloid hypothesis of AD have shown little promise. The future of novel treatments targeting other pathophysiological processes in the disease is uncertain. Growing evidence supports a role for neurovascular inflammation as a major causative or exacerbating factor in AD onset and progression. However, the scientific community has yet to label AD a vascular disease and questions remain about the viability of neurovascular inflammation as a potential therapeutic target. To address this controversy head-on, the New York Academy of Sciences will present a 1-day symposium and simulcast Webinar, “Alzheimer’s Disease Viewed as a Neurovascular Inflammatory Disorder” on 12/6/2016. The goal of this symposium is to evaluate clinical and preclinical data investigating the role of neurovascular pathology in the development of AD. Critical barriers to understanding how to clinically test vascular-based hypotheses for the treatment of AD will be discussed, including recent imaging advances for monitoring disease progression. Moreover, emerging science on molecular and physiological processes that can be leveraged as targets for novel therapeutics will be presented. This symposium will fill an important gap in the conference landscape, presenting a focused, in-depth discussion on the synergies between AD and vascular disease research, building upon the recently defined need to better understand neurovascular dysregulation in AD and vascular dementia (36). This landmark event will unite 200 in-person basic, translational, and clinical researchers — along with a global audience of Webinar participants — from academia, industry, government, and non-profit organizations, working on neurodegenerative disorders and vascular disease in an effort to understand, prevent, and treat AD and vascular dementias such as small vessel disease (SVD). Sessions will address 5 central aims: (i) Elucidate the relationship between genetic information and neurovascular pathology in AD and SVD; (ii) Explore novel molecular targets and physiological processes critical to vascular function and CNS health, using human studies and animal models; (iii) Describe clinical aspects of neurovascular dysregulation and inflammation in AD and SVD and identify biomarkers for vascular-based mechanisms; (iv) Identify knowledge gaps and future research required for breakthroughs in prevention and treatment of AD; and (v) Showcase and encourage the participation of Early-Career, female, and Underrepresented Minority investigators via short talks, poster presentations and prizes, travel fellowships, and discounted registration. In addition, the NINDS’ specific goal of disseminating information will be met through a simulcast Webinar and publication of an enduring open-access Academy eBriefing. A collaborative, multidisciplinary approach will be critical to meeting the urgent unmet need for AD patients. To that end, this event will consider new disease mechanisms and therapeutic targets for AD, from a broad range of perspectives.

阿尔茨海默病被视为一种神经血管炎症性疾病