Alzheimer's Disease Viewed as a Neurovascular Inflammatory Disorder
Alzheimer's Disease Viewed as a Neurovascular Inflammatory Disorder
批准号:
9195011
负责人:
Costantino Iadecola
金额:
$1.5万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-12-06 至 2017-12-05
关键词:
AcademiaAcademyAddressAgeAlzheimer&aposs DiseaseAmyloidAnimal ModelAreaAwards and PrizesBasic ScienceBiological MarkersBiologyBlood - brain barrier anatomyBlood VesselsBrainCerebral Amyloid AngiopathyCerebrovascular DisordersChild CareClinicalClinical SciencesClinical TrialsCollaborationsCommunicationCommunitiesDataDementiaDeveloping CountriesDevelopmentDisabled PersonsDiseaseDisease ProgressionEnsureEnvironmentEtiologyEventFacultyFamilyFellowshipFemaleFosteringFoundationsFunctional disorderFutureGeneticGoalsGovernmentHeadHealthHealthcare SystemsHumanImageImmune responseImpaired cognitionImpairmentIndustryInflammationInflammatoryInternationalKnowledgeLabelLifeLinkMapsMedical ResearchMicrovascular DysfunctionMolecularMolecular TargetMonitorNational Institute of Neurological Disorders and StrokeNeurodegenerative DisordersNeuronsNew YorkNonprofit OrganizationsOnset of illnessOralParticipantPathologyPatientsPersonsPhysiological ProcessesPopulationPreventionPrizeProcessPublicationsPublishingResearchResearch PersonnelRisk FactorsRoleScienceStrokeStudy modelsTechnologyTestingTranslatingTranslationsTravelUnderrepresented MinorityUpdateVascular DementiaVascular DiseasesWomanWorkabstractingaging populationbasebiomarker identificationcareerdata exchangediscounteffective therapygenetic informationglobal healthhealth economicsimprovedinsightinterdisciplinary approachknowledge basemeetingsminority investigatorneuropathologyneurovascularnew therapeutic targetnovelpatient populationposterspre-clinicalpreventracial minorityrepositorysocioeconomicssymposiumtherapeutic targettoolvascular contributionsvascular inflammationwebinar
中文摘要
阿尔茨海默病被视为一种神经血管炎症性疾病
英文摘要
Alzheimer’s Disease Viewed as a Neurovascular Inflammatory Disorder
PROJECT SUMMARY / ABSTRACT
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder lacking effective treatments. Most
clinical trials testing the long-standing amyloid hypothesis of AD have shown little promise. The future of novel
treatments targeting other pathophysiological processes in the disease is uncertain. Growing evidence
supports a role for neurovascular inflammation as a major causative or exacerbating factor in AD onset and
progression. However, the scientific community has yet to label AD a vascular disease and questions remain
about the viability of neurovascular inflammation as a potential therapeutic target. To address this controversy
head-on, the New York Academy of Sciences will present a 1-day symposium and simulcast Webinar,
“Alzheimer’s Disease Viewed as a Neurovascular Inflammatory Disorder” on 12/6/2016. The goal of this
symposium is to evaluate clinical and preclinical data investigating the role of neurovascular pathology in the
development of AD. Critical barriers to understanding how to clinically test vascular-based hypotheses for the
treatment of AD will be discussed, including recent imaging advances for monitoring disease progression.
Moreover, emerging science on molecular and physiological processes that can be leveraged as targets for
novel therapeutics will be presented. This symposium will fill an important gap in the conference landscape,
presenting a focused, in-depth discussion on the synergies between AD and vascular disease research,
building upon the recently defined need to better understand neurovascular dysregulation in AD and vascular
dementia (36). This landmark event will unite 200 in-person basic, translational, and clinical researchers —
along with a global audience of Webinar participants — from academia, industry, government, and non-profit
organizations, working on neurodegenerative disorders and vascular disease in an effort to understand,
prevent, and treat AD and vascular dementias such as small vessel disease (SVD). Sessions will address
5 central aims: (i) Elucidate the relationship between genetic information and neurovascular pathology in AD
and SVD; (ii) Explore novel molecular targets and physiological processes critical to vascular function and CNS
health, using human studies and animal models; (iii) Describe clinical aspects of neurovascular dysregulation
and inflammation in AD and SVD and identify biomarkers for vascular-based mechanisms; (iv) Identify
knowledge gaps and future research required for breakthroughs in prevention and treatment of AD; and (v)
Showcase and encourage the participation of Early-Career, female, and Underrepresented Minority
investigators via short talks, poster presentations and prizes, travel fellowships, and discounted registration.
In addition, the NINDS’ specific goal of disseminating information will be met through a simulcast Webinar
and publication of an enduring open-access Academy eBriefing. A collaborative, multidisciplinary
approach will be critical to meeting the urgent unmet need for AD patients. To that end, this event will
consider new disease mechanisms and therapeutic targets for AD, from a broad range of perspectives.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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批准号:10419353
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ApoE4 and mechanisms of diffuse white matter injury
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资助金额:$70.43万
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Dietary sodium, neurovascular dysfunction and cerebrovascular risk
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项目类别:
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资助金额:$59.9万
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财政年份:2015
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负责人:Costantino Iadecola
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依托单位:
Hypertension and neurovascular dysfunction
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批准号:9915965
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项目类别:
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资助金额:$46.61万
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财政年份:2015
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负责人:Costantino Iadecola
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依托单位:
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular Risk
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批准号:10650322
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项目类别:
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资助金额:$57.41万
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财政年份:2015
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负责人:Costantino Iadecola
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依托单位:
Dietary sodium, neurovascular dysfunction and cerebrovascular risk
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批准号:10447695
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项目类别:
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资助金额:$57.41万
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财政年份:2015
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负责人:Costantino Iadecola
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CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
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项目类别:
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项目类别:
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资助金额:$36.6万
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财政年份:2011
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负责人:Costantino Iadecola
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依托单位:
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依托单位:
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项目类别:
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资助金额:$35.67万
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财政年份:2011
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负责人:Costantino Iadecola
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依托单位:
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资助金额:$36.97万
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Forebrain Plasticity in Hypertension
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海外基金