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Electronic Access to Mouse Tumor Data

小鼠肿瘤数据的电子获取

基本信息

批准号：
9264508
负责人：
CAROL J BULT
金额：
$ 78.83万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-01-10 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9264508
关键词：
Access to Information Affect Alleles Animal Model Bioinformatics Biological Models Biology CRISPR/Cas technology Cancer Biology Cancer Model Clinical Data Clinical Research Collaborations Communities Community Outreach Complex Computer software Credentialing Data Data Set Databases Development Diagnostic Disease Educational workshop Evaluation Experimental Models Feedback Frequencies Funding Gene Expression Genes Genetic Genetic Research Genetically Engineered Mouse Genomics Goals Growth Histopathology Human Human Biology Human Genetics Hyperplasia Hypertrophy Image Immune Inbreeding Incidence Individual Informatics International Investigation Laboratory mice Large-Scale Sequencing Light Literature Maintenance Malignant Neoplasms Modality Modeling Molecular Genetics Mouse Strains Mus Mutate Mutation Neoplasms Oncogenes Pathologist Pathology Patients Pattern Peer Review Pharmaceutical Preparations Phenotype Play Positioning Attribute Predisposition Property Reaction Time Reporting Research Research Infrastructure Research Personnel Resources Review Literature Role Semantics Services Side Surveys Swelling Tissues Tumor Biology Tumor Suppressor Proteins Variant Visualization software Work Xenograft Model Xenograft procedure anticancer research base cancer genetics cancer genome cancer genomics cancer therapy clinically relevant comparative comparative genomics data acquisition data archive data modeling design genetic resource genome-wide genomic data human cancer mouse model humanized mouse indexing insight mouse development mouse model mutant neoplastic new technology novel strategies novel therapeutics pre-clinical precise genome editing public health relevance response symposium tool trait translational cancer research tumor tumorigenesis usability

项目摘要

DESCRIPTION (provided by applicant): The laboratory mouse is the preeminent animal model system for investigation into the biology and genetics of human cancer. Mouse models have provided key insights into cancer susceptibility, the molecular genetics of tumor suppressor and oncogenes, and therapy response in pre-clinical and co-clinical studies. Human tumors engrafted into immune compromised and humanized mice (aka, Patient Derived Xenografts) are playing an increasingly important role in basic and translational cancer biology. The Mouse Tumor Biology (MTB) database is a unique on-line compendium of mouse models for human cancer. MTB provides electronic access to expertly curated information on diverse mouse models for human cancer along with tools for accessing and visualizing associated data from these models (http://tumor.informatics.jax.org). MTB integrates data from peer-reviewed literature and from direct submissions from researchers. Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus (GEO), and ArrayExpress. The MTB project team has a strong record of supporting the use of the mouse in basic cancer biology and genetics research by providing expertly curated data that facilitates the selection of appropriate strains of mice for cancer genetics research. In this proposal we describe our plans for the continued development of MTB with an emphasis on expanded support for mouse-human comparative cancer genomics and the use of the mouse in translational and pre-clinical work. The major goals for the project renewal include the following: *continue to populate MTB with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, * incorporate new data types and develop new user interfaces for accessing information and data related to Patient Derived Xenograft (PDX) models of human cancer, develop new interfaces to support mouse-human comparative cancer genomics, and support the infrastructure of MTB and our user community through ongoing database maintenance, development of new software components, user support services, and community outreach activities.

描述(申请人提供)：实验小鼠是研究人类癌症生物学和遗传学的卓越动物模型系统。小鼠模型提供了对癌症易感性、肿瘤抑制基因和癌基因的分子遗传学以及临床前和联合临床研究中的治疗反应的关键见解。移植到免疫受损和人源化小鼠体内的人类肿瘤(又名患者来源的异种移植物)在基础和转化性癌症生物学中发挥着越来越重要的作用。小鼠肿瘤生物学(MTB)数据库是人类癌症小鼠模型的唯一在线概要。MTB提供对人类癌症不同小鼠模型的专业精选信息的电子访问，以及用于访问和可视化这些模型的相关数据的工具(http://tumor.informatics.jax.org).MTB整合了同行评审文献和研究人员直接提交的数据。MTB中的数据也从其他生物信息学资源中获得，包括PathBase、基因表达总览(GEO)和ArrayExpress。MTB项目团队通过提供专业精选的数据，促进为癌症遗传学研究选择合适的小鼠品系，在支持小鼠在基础癌症生物学和遗传学研究中的使用方面有着良好的记录。在这份提案中，我们描述了我们继续发展结核分枝杆菌的计划，重点是扩大对老鼠-人类比较癌症基因组学的支持，并将老鼠用于翻译和临床前工作。项目续签的主要目标包括： *继续用近亲交配、突变和基因工程小鼠中特定菌株致癌模式的数据填充MTB；*纳入新的数据类型并开发新的用户界面，以访问与患者衍生的人类癌症(PDX)模型相关的信息和数据；开发新的界面以支持鼠-人比较癌症基因组学；并通过持续的数据库维护、开发新的软件组件、用户支持服务和社区推广活动，支持MTB和我们的用户社区的基础设施。