Harmonization of existing registries of diabetes in youth

协调现有青少年糖尿病登记处

• 批准号: 9229031
• 负责人: Dana Dabelea
• 金额: $ 19.34万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-19 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9229031
• 关键词: 20 year old; Address; Affect; Age; Age-Years; Area; Bilateral; Characteristics; Childhood; Clinical; Colorado; Country; Data; Data Set; Demographic Factors; Diabetes Mellitus; Diabetes prevention; Educational workshop; Elements; Endocrinologist; Ensure; Environmental Exposure; Epidemiology; Ethnic Origin; Evaluation; Evolution; Funding Opportunities; Future; Future Generations; Geographic Locations; Goals; Health Care Costs; Health Policy; Healthcare; Hospitals; Hygiene; Incidence; India; Insulin-Dependent Diabetes Mellitus; Knowledge; Lead; Location; Medical Research; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pattern; Phenotype; Policies; Population; Population Surveillance; Prevalence; Provider; Public Health; Quality of Care; Quality of life; Race; Recording of previous events; Registries; Reporting; Research; Research Personnel; Risk; Risk Factors; SEARCH for Diabetes in Youth; Site; Solid; System; Technology; Time; Work; Youth; age group; aged; data registry; diabetes management; diabetes risk; epidemiology study; high risk; improved; innovation; insight; interest; mortality; nutrition; population based; public health relevance; response; sex; surveillance network; trend; young adult

 DESCRIPTION (provided by applicant): Diabetes affects nearly 26 million people in the U.S. and over 62 million in India, placing these nations second and third in the world in terms of population burden of diabetes. Diabetes is reported as increasing in younger age groups both in India and the US, with long-term implications for burden of complications, health care costs, and risk of diabetes in future generations. In 2000, the Indian Council of Medical Research (ICMR) established the Registry of People with Diabetes with Young Age at Onset (YDR), including youth and young adults less than 25 years of age from eight sites across India. In the U.S., the SEARCH for Diabetes in Youth study is a multicenter epidemiologic study conducting population-based case ascertainment of youth with diabetes before age 20 years since 2001, currently in five locations across the U.S. However, the ability to compare the epidemiologic characteristics of diabetes in youth between India and the U.S. is at present lacking. Knowledge of whether prevalence, incidence, mortality, and clinical presentation, treatment, quality of care and quality of life differ can lead to new insights into the potential causes and improved treatment. A sensitive surveillance system in both countries can also inform policy about whether changes in underlying risk factors such as obesity, environmental exposures and other factors are leading to an increase in risk, or whether improved nutrition and environmental hygiene have reduced risk over time. These challenges have been identified by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the ICMR who sponsored an Indo-U.S. workshop titled "Innovative Approaches and Technologies for Diabetes Prevention and Management", held on February 4-6, 2013, in New Delhi. In response to the recent NIDDK funding opportunity announcement (FOA) we propose to conduct preliminary harmonization work of U.S. and Indian registries of childhood diabetes to address several specific aims: AIM 1: To harmonize the Indian YDR and the SEARCH registry in the U.S. AIM 2: To compare phenotypic, clinical and demographic characteristics by type of diabetes between YDR and SEARCH. AIM 3: To compare the burden of diabetes in youth by age, sex, race/ethnicity and type of diabetes between India and the US. Harmonization of the SEARCH and YDR registries is a critical step towards building capacity to understand global trends. This application is significant in proposing to harmonize registries covering both T1 and T2D at a critical moment in history when trends in diabetes are dynamic yet poorly understood from a global perspective.

 描述（由申请人提供）：糖尿病影响美国近2600万人，印度超过6200万人，在糖尿病人口负担方面，这些国家在世界上排名第二和第三。据报道，在印度和美国，糖尿病在年轻人群中呈上升趋势，对并发症负担、医疗保健费用和后代患糖尿病的风险具有长期影响。2000年，印度医学研究理事会（ICMR）建立了年轻发病糖尿病患者登记处（YDR），包括来自印度8个地点的青年和25岁以下的年轻人。在美国，青年糖尿病研究是一项多中心流行病学研究，自2001年以来，对20岁以下的糖尿病青年进行基于人群的病例确定，目前在美国的五个地点进行。然而，目前缺乏比较印度和美国青年糖尿病流行病学特征的能力。了解患病率、发病率、死亡率和临床表现、治疗、护理质量和生活质量是否不同，可以对潜在原因和改善治疗产生新的见解。这两个国家的敏感监测系统还可以为政策提供信息，了解肥胖、环境暴露和其他因素等潜在风险因素的变化是否导致风险增加，或者营养和环境卫生的改善是否随着时间的推移降低了风险。国家糖尿病、消化和肾脏疾病研究所（NIDDK）和ICMR已经确定了这些挑战，ICMR赞助了2013年2月4日至6日在新德里举行的题为“糖尿病预防和管理的创新方法和技术”的印美研讨会。为了响应最近的NIDDK资助机会公告（FOA），我们建议对美国和印度儿童糖尿病登记处进行初步协调工作，以解决几个具体目标：目的1：协调印度YDR和美国的YDR登记处目的2：比较YDR和YDR之间糖尿病类型的表型，临床和人口统计学特征。目的3：按年龄、性别、种族/民族和糖尿病类型比较印度和美国青年的糖尿病负担。协调统一《京都议定书》和《千年发展目标》登记册是建设了解全球趋势的能力的一个关键步骤。在糖尿病趋势动态但从全球角度了解甚少的历史关键时刻，该申请对于协调涵盖T1和T2 D的登记研究具有重要意义。