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Highly-compliant Microneedle Arrays for Peripheral Nerve Mapping

用于周围神经映射的高度顺应性微针阵列

基本信息

批准号：
9415137
负责人：
Timothy M. Bruns
金额：
$ 93.89万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-24 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9415137
关键词：
Action Potentials Acute Adopted Affect American Amplifiers Anatomy Anesthesia procedures Animal Experiments Animal Model Animals Axon Behavior assessment Bladder Bladder Control Bladder Dysfunction Blood-Nerve Barrier Brain Bypass Caliber Cell Communication Chronic Clinical Communication Cues Cytology Data Collection Data Set Devices Dimensions Distal Distant Effectiveness Electrodes Electrophysiology (science)Environment Evaluation Event Felis catus Fibrosis Filament Future Ganglia Goals Healthcare Healthcare Systems Histologic Implant Intercept Learning Letters Lower urinary tract Mechanics Methods Mission Modification Monitor Motor Needles Nerve Neurons Noise Operative Surgical Procedures Organ Organism Paresthesia Pathway interactions Pelvis Penetration Peripheral Nerves Peripheral Nervous System Pharmaceutical Preparations Physiological Quality of life Rattus Research Personnel Sacral nerve Sensory Sexual Arousal Signal Transduction Sorting - Cell Movement Spinal Cord Spinal nerve root structure Stress Stretching Structure Surface System Techniques Technology Temperature Testing Time Tissues Utah Validation Volition Wireless Technology alertness awake body system density design digital effective therapy experimental study flexibility improved in vivo interfacial knowledge of results millimeter neural circuit neuroregulation neurotransmission novel physical separation relating to nervous system social tool usability

项目摘要

Project Summary A neural interface is needed that will allow for monitoring the diverse neural anatomy in chronic, behaving animal experiments. The state-of-the-art tools including both flexible surface arrays and stiff penetrating arrays have well-known limitations including low signal-to-noise and unstable recordings over time. The goal of this project is to develop and test a novel device concept that combines stretchable substrates with high-density needles to penetrate through the epineurium of ganglia and peripheral nerves. Nothing in this scale has been demonstrated or attempted to date. This approach has the potential to mitigate the poor fidelity of surface arrays and eliminate damage induced from larger penetrating arrays. Initial validation testing on ganglionic and nerve interfaces will yield a variety of control signals from the sympathetic, parasympathetic, and somatic motor and sensory pathways that innervate the bladder and lower urinary tract. Although bladder dysfunction is a significant healthcare problem, the underlying neural control is not well understood. This shortfall of knowledge results in only partially effective therapies, including drugs and neurostimulators. In Aim 1, microneedle array design and fabrication will yield several device iterations will be evaluated in benchtop phantom experiments to demonstrate insertion effectiveness and ease-of-use. In Aim 2, acute and short-term chronic in vivo experiments will allow us to further evaluate and improve usability, demonstrate signal fidelity, and perform histological evaluation. We expect that this technology and subsequent learning opportunities will lead to significant improvements in neuromodulation devices.

项目概要需要一个神经接口来监测慢性行为的不同神经解剖结构动物实验。最先进的工具，包括柔性表面阵列和刚性穿透阵列具有众所周知的局限性，包括信噪比低和随着时间的推移录音不稳定。此举的目标该项目是开发和测试一种新颖的设备概念，将可拉伸基材与高密度相结合针刺穿神经节和周围神经的神经外膜。在这个规模上还没有迄今为止已证明或尝试过。这种方法有可能减轻表面保真度差的问题阵列并消除较大穿透阵列引起的损坏。神经节和神经节的初步验证测试神经接口将产生来自交感神经、副交感神经和躯体神经的各种控制信号支配膀胱和下尿路的运动和感觉通路。虽然膀胱功能障碍作为一个重大的医疗保健问题，潜在的神经控制尚不清楚。这一不足知识只能导致部分有效的治疗，包括药物和神经刺激器。在目标 1 中，微针阵列设计和制造将产生多个设备迭代，将在台式机上进行评估模型实验证明插入有效性和易用性。在目标 2 中，急性和短期长期体内实验将使我们能够进一步评估和提高可用性，证明信号保真度，并进行组织学评估。我们期望这项技术和后续的学习机会导致神经调节装置的显着改进。