Development of a novel multi-modal spinal root interface

 描述(由申请人提供)：尽管膀胱功能障碍是一个重要的医疗问题，但潜在的神经控制还没有被很好地理解。这种知识的缺乏只导致了包括药物和神经刺激剂在内的部分有效的治疗方法。需要一种神经接口，以便在慢性行为动物实验中监测不同的神经解剖结构。该项目的目标是开发并对一种新的脊神经根神经接口进行初步验证测试，我们预计该接口将产生来自交感、副交感和躯体运动和感觉通路的完整神经控制信号，这些通路支配膀胱和下尿路。在目标1中，电极的设计和制造将产生几次设备迭代，这些设备将在急性活体实验中进行评估。在目标2中，将开发一种慢性分布式植入系统，并在几周的清醒状态下进行体内实验。我们预计，这项技术和随后的学习机会将导致神经调节设备的显著改进。

 DESCRIPTION (provided by applicant): Although bladder dysfunction is a significant healthcare problem, the underlying neural control is not well understood. This shortfall of knowledge results in only partially effective therapies, including drugs and neurostimulators. A neural interface is needed that will allow for monitoring the diverse neural anatomy in chronic, behaving animal experiments. The goal of this project is to develop and perform initial validation testing on a novel spinal root neural interface that we expect will yield a full concertof neural control signals from the sympathetic, parasympathetic, and somatic motor and sensory pathways that innervate the bladder and lower urinary tract. In Aim 1, electrode design and fabrication will yield several device iterations that will be evaluated in acute in vivo experiment. In Aim 2, a chronic distributed implant system will be developed and evaluated over several weeks of awake, behaving in vivo experiments. We expect that this technology and subsequent learning opportunities will lead to significant improvements in neuromodulation devices.