Development of a novel multi-modal spinal root interface

新型多模式脊柱根接口的开发

基本信息

批准号：
9529461
负责人：
Timothy M. Bruns
金额：
$ 14.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9529461
关键词：
Acute Adopted Adoption Adverse effects Affect Afferent Neurons American Anatomy Animal Experiments Animals Automobile Driving Axon Bilateral Bladder Bladder Control Bladder Dysfunction Caring Cells Chronic Complex Custom Data Collection Data Set Development Devices Dorsal Effectiveness Electric Stimulation Electrodes Electronics Electrophysiology (science)Etiology Family Felidae Frequencies Functional disorder Future Goals Healthcare Healthcare Systems Human Implant Individual Intestines Learning Link Literature Location Lower urinary tract Mechanics Microelectrodes Mission Modality Modeling Monitor Motor Motor Neurons Nerve Nervous System control Neurons Pathology Pathway interactions Pelvis Performance Peripheral Nerves Peripheral Nervous System Pharmaceutical Preparations Pharmacology Physiological Plant Roots Population Procedures Process Quality of life Risk Sensory Signal Transduction Silicon Site Spinal Spinal Ganglia Spinal nerve root structure Stimulus Surface System Technology Testing Thinness Time Tissues Urination Validation Ventral Roots Visceral Work afferent nerve awake base design effective therapy electrical property experimental study improved improved functioning in vivo insight knowledge of results mechanical properties multimodality nerve supply neural circuit neurophysiology neuroregulation neurotransmission novel patient subsets preference public health relevance relating to nervous system response scale up spine bone structure

项目摘要

DESCRIPTION (provided by applicant): Although bladder dysfunction is a significant healthcare problem, the underlying neural control is not well understood. This shortfall of knowledge results in only partially effective therapies, including drugs and neurostimulators. A neural interface is needed that will allow for monitoring the diverse neural anatomy in chronic, behaving animal experiments. The goal of this project is to develop and perform initial validation testing on a novel spinal root neural interface that we expect will yield a full concertof neural control signals from the sympathetic, parasympathetic, and somatic motor and sensory pathways that innervate the bladder and lower urinary tract. In Aim 1, electrode design and fabrication will yield several device iterations that will be evaluated in acute in vivo experiment. In Aim 2, a chronic distributed implant system will be developed and evaluated over several weeks of awake, behaving in vivo experiments. We expect that this technology and subsequent learning opportunities will lead to significant improvements in neuromodulation devices.

描述（由应用程序提供）：尽管膀胱功能障碍是一个重大的医疗保健问题，但基本的神经控制尚不清楚。知识短缺仅导致部分有效的疗法，包括药物和神经刺激剂。需要神经元界面，该界面将允许在慢性动物实验中监测发散的神经解剖结构。该项目的目的是在新型的脊柱根神经元界面上开发和执行初始验证测试，我们期望这些界面会产生来自交感神经，副交感神经，体细胞运动和感觉途径的神经元控制信号的全部关注，从而使膀胱和较低的泌尿道负责。在AIM 1中，电极设计和制造将产生几种将在急性体内实验中评估的设备迭代。在AIM 2中，将在几周的清醒中开发和评估慢性分布式植入物系统，并在体内实验。我们预计，这项技术和随后的学习机会将导致神经调节设备的重大改进。