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Development of a novel multi-modal spinal root interface

新型多模式脊柱根接口的开发

基本信息

批准号：
9529461
负责人：
Timothy M. Bruns
金额：
$ 14.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9529461
关键词：
Acute Adopted Adoption Adverse effects Affect Afferent Neurons American Anatomy Animal Experiments Animals Automobile Driving Axon Bilateral Bladder Bladder Control Bladder Dysfunction Caring Cells Chronic Complex Custom Data Collection Data Set Development Devices Dorsal Effectiveness Electric Stimulation Electrodes Electronics Electrophysiology (science)Etiology Family Felidae Frequencies Functional disorder Future Goals Healthcare Healthcare Systems Human Implant Individual Intestines Learning Link Literature Location Lower urinary tract Mechanics Microelectrodes Mission Modality Modeling Monitor Motor Motor Neurons Nerve Nervous System control Neurons Pathology Pathway interactions Pelvis Performance Peripheral Nerves Peripheral Nervous System Pharmaceutical Preparations Pharmacology Physiological Plant Roots Population Procedures Process Quality of life Risk Sensory Signal Transduction Silicon Site Spinal Spinal Ganglia Spinal nerve root structure Stimulus Surface System Technology Testing Thinness Time Tissues Urination Validation Ventral Roots Visceral Work afferent nerve awake base design effective therapy electrical property experimental study improved improved functioning in vivo insight knowledge of results mechanical properties multimodality nerve supply neural circuit neurophysiology neuroregulation neurotransmission novel patient subsets preference public health relevance relating to nervous system response scale up spine bone structure

项目摘要

DESCRIPTION (provided by applicant): Although bladder dysfunction is a significant healthcare problem, the underlying neural control is not well understood. This shortfall of knowledge results in only partially effective therapies, including drugs and neurostimulators. A neural interface is needed that will allow for monitoring the diverse neural anatomy in chronic, behaving animal experiments. The goal of this project is to develop and perform initial validation testing on a novel spinal root neural interface that we expect will yield a full concertof neural control signals from the sympathetic, parasympathetic, and somatic motor and sensory pathways that innervate the bladder and lower urinary tract. In Aim 1, electrode design and fabrication will yield several device iterations that will be evaluated in acute in vivo experiment. In Aim 2, a chronic distributed implant system will be developed and evaluated over several weeks of awake, behaving in vivo experiments. We expect that this technology and subsequent learning opportunities will lead to significant improvements in neuromodulation devices.