Assessing vigilance with resting-state fMRI

项目摘要 静息态功能磁共振成像（rsfMRI）是一种领先的无创性方法， 表征人类大脑的功能连接和静息状态活动。在我们之前的工作中 我们已经发现，rsfMRI测量的连接性和信号方差可以显着改变， 受试者的警戒状态。除非考虑到这些警惕性的差异， 连接强度和信号方差可以被解释为疾病相关的变化。目前， 脑活动的脑电图（EEG）测量被认为是用于测量脑活动的标准方法。 警惕性评估。然而，由于技术上的挑战， 同时获得rsfMRI和EEG测量所涉及的物流。一种替代方法， 不需要采集EEG数据将极大地方便在广泛的范围内评估警惕性， rsfMRI研究。本项目的目标是开发和验证基于rsfMRI的警戒措施。的 本研究的目的是（1）开发和优化基于rsfMRI的警戒水平和波动措施 和（2）在患有精神分裂症的受试者的样品中进行该方法的功效的初步测试。

Project Summary Resting-state functional magnetic resonance imaging (rsfMRI) is a leading method for the non-invasive characterization of the functional connectivity and resting-state activity of the human brain. In our prior work we have found that rsfMRI measures of connectivity and signal variance can be significantly altered by the subject's vigilance state. Unless these differences in vigilance are taken into account, differences in connectivity strength and signal variance might be interpreted as a disease-related changes. Currently, electroencephalographic (EEG) measures of brain activity are considered the standard approach for the assessment of vigilance. However, their use in rsfMRI studies is limited due to the technical challenges and logistics involved in obtaining simultaneous rsfMRI and EEG measurements. An alternative approach that does not require the acquisition of EEG data would greatly facilitate the assessment of vigilance in a wide range of rsfMRI studies. The goal of this project is to develop and validate an rsfMRI-based measure of vigilance. The aims of the study are to (1) Develop and optimize rsfMRI-based measures of vigilance levels and fluctuations and (2) Perform a preliminary test of the efficacy of the method in a sample of subjects with schizophrenia.