Neuroimaging Core

神经成像核心作为仪器，数据采集，处理和分析的资源。 支持项目1和2中进行的实验的分析。这个核心将提供尖端的 神经成像的进步和计算工具，这对优化数据处理很重要。的 该核心的主任，托马斯刘博士，也是加州大学圣地亚哥分校功能磁中心主任 共振成像（fMRI），因此，承担了UCSD现有的重要基础设施 为这个提案提供了一个功能磁共振成像中心。此外，刘博士在灌注成像方面的专业知识将有助于提供 分析方法，以确定是否一般差异，血液灌注跨组解释 BOLD功能磁共振成像差异期间的内感受和线索反应任务，并将确保高质量 神经成像数据。该核心的具体目标是： (1)利用加州大学圣地亚哥分校功能磁共振成像中心开发的神经成像程序， 控制正在进行的实验。 这一目标将帮助我们优化成像分析步骤，并实施明确的质量控制 与其他大规模fMRI研究相似。 (2)提供核心计算基础设施，以标准化和优化神经成像管道。 这将有助于我们比较项目1和项目2获得的图像，以更好地描绘 成瘾周期中内感受失调的程度。 (3)为所有CIDIA相关研究者提供神经影像学的基础和高级培训 采集和分析。 这一目标主要集中在神经影像学核心的联合收割机教育和培训活动， 为了节省我们引进新研究者的能力，保持神经影像学的高水平专业知识， 研究人员，并结合新的见解，从文献中优化图像分析途径。 通过实现这些目标，核心将主要支持项目1和2，这将使其更容易， 更适合于跨项目比较数据集。然而，我们也设想这个核心将开始 探索未来动物神经成像的可能性，这可以在一个完整的中心扩展， 这个最初的项目。

The Neuroimaging Core functions as a resource for instrumentation, data acquisition, processing, and analysis in support of the experiments conducted in Projects 1 and 2. This core will provide cutting edge neuroimaging advances and computational tools, which are important to optimize data processing. The director of this core, Dr. Thomas Liu, is also the Director of the UCSD Center for Functional Magnetic Resonance Imaging (fMRI) and, therefore, brings to bear the significant existing infrastructure of the UCSD Center for fMRI for this proposal. Moreover, Dr. Liu's expertise in perfusion imaging will help provide analysis approaches to determine whether general differences in blood perfusion across groups account for BOLD fMRI differences during the interoception and cue reactivity tasks, and will ensure high quality neuroimaging data. The specific aims of this core are: (1) To utilize neuroimaging procedures developed at the UCSD Center for fMRI to provide continued quality control of ongoing experiments. This aim will help us to optimize our imaging analyses steps and to have explicit quality control implemented similar to that of other large-scale fMRI studies. (2) To provide a core computational infrastructure to standardize and optimize the neuroimaging pipeline. This will help us to compare images obtained for Project 1 with those of Project 2 to better delineate the degree of dysregulated interoception across the addiction cycle. (3) To provide basic and advanced training for all CIDIA associated investigators for neuroimaging acquisition and analysis. This aim is focused primarily on combine educational and training activities in the Neuroimaging Core so as to economize our ability to bring in new investigators, maintain high level of expertise among neuroimaging investigators, and incorporate new insights from the literature to optimize the image analysis pathway. By accomplishing these aims, the core will primarily support Projects 1 and 2, which will make it easier and more appropriate to compare data sets across projects. However, we also envision that this core will begin to explore the possibility for future animal neuroimaging, which could be done in a full center extension of this initial project.