Asymmetric Meiotic Cell Division of Mammalian Oocytes
哺乳动物卵母细胞的不对称减数分裂
基本信息
- 批准号:9352238
- 负责人:
- 金额:$ 33.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-12 至 2020-06-30
- 项目状态:已结题
- 来源:
- 关键词:ANGPTL2 geneActinsActomyosinAgingAutomobile DrivingBiological ModelsCell PolarityCell divisionCellsChromatinChromosomesClinicalComplexCongenital AbnormalityCytoplasmCytoplasmic streamingCytoskeletonDataDefectDevelopmentEmbryonic DevelopmentEndoplasmic ReticulumExperimental ModelsF-ActinFamilyFertilityFertilizationFutureGenerationsGenomeGoalsHumanImaging technologyImportinsInfertilityKnowledgeLiquid substanceMeasurementMeasuresMediatingMeiosisMembraneMethodsModelingMolecularMolecular GeneticsMorphologyMovementMusMyosin Type IINuclearOocytesOrganellesOrganismPathway interactionsPatternPeripheralPositioning AttributeProcessProductionPropertyResearchSignal TransductionSiteStem cellsSystemTestingbiological systemsbiophysical toolscell typedesignfascinateimprovedinnovationinsightmathematical analysismigrationnovelnovel therapeuticspreventsegregationself organizationspatiotemporaltreadmillvectorzygote
项目摘要
The goal of this project is to understand how a mammalian organism initiates its multicellular
development by completing its very first asymmetric cell divisions (ACD) - during meiotic
maturation and fertilization of the oocyte. Meiotic ACD not only is critically important for successful
fertilization and full developmental potential of the zygote, but also offers unique and fascinating
insights into the mechanism of self-organization, a most fundamental property of biological
systems. Recent studies from our lab and others using mouse oocytes as the model system have
begun to unravel dynamic and bi-directional interplays between the chromosomes and the actin
cytoskeleton in setting up oocyte cell polarity for ACD and potentially also for future embryonic
development. In the proposed research, we plan to build on these exciting recent findings to
answer three mechanistic questions: 1) how actin dynamics drive oocyte symmetry breaking
(Aim1); 2) how the nuclear genome directly signals morphological reorganization on the cellular
level (Aim2); and 3) how an unusual mechanism of dynamic force production patterns a large cell
(the oocyte) and potentially impacts organelle segregation and early embryonic development
(Aim3). To answer these questions, we will employ a highly innovative approach that entails a full
integration of molecular genetic methods with cutting-edge imaging technologies, biophysical tools
and mathematical analysis. Because clinical evidence suggests that defects in the polarized
organization of mature oocytes are associated with aging-related infertility, our study not only has
the potential for novel intellectual contribution to the understanding of self-organization in cellular
systems but may also provide the basis for future development of new methods that help improve
human fertility and prevent birth defects.
这个项目的目标是了解哺乳动物生物体是如何启动其多细胞的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('RONG LI', 18)}}的其他基金
Cellular dynamics in division, motility and evolutionary adaptation
分裂、运动和进化适应的细胞动力学
- 批准号:
9489376 - 财政年份:2016
- 资助金额:
$ 33.93万 - 项目类别:
Cellular dynamics in division, motility and evolutionary adaptation
分裂、运动和进化适应的细胞动力学
- 批准号:
9265495 - 财政年份:2016
- 资助金额:
$ 33.93万 - 项目类别:
Cellular dynamics in division, motility and evolutionary adaptation
分裂、运动和进化适应的细胞动力学
- 批准号:
9071732 - 财政年份:2016
- 资助金额:
$ 33.93万 - 项目类别:
The impact of aneuploidy on neuronal cell behavior
非整倍体对神经细胞行为的影响
- 批准号:
9101062 - 财政年份:2015
- 资助金额:
$ 33.93万 - 项目类别:
The impact of aneuploidy on neuronal cell behavior
非整倍体对神经细胞行为的影响
- 批准号:
8684077 - 财政年份:2014
- 资助金额:
$ 33.93万 - 项目类别:
The effect of aneuploidy on cellular physiology and adaptation
非整倍性对细胞生理学和适应的影响
- 批准号:
8657052 - 财政年份:1999
- 资助金额:
$ 33.93万 - 项目类别:
The effect of aneuploidy on cellular physiology and adaptation
非整倍性对细胞生理学和适应的影响
- 批准号:
8392874 - 财政年份:1999
- 资助金额:
$ 33.93万 - 项目类别:
The Mechanism and Regulation of Cytokinesis in Yeast
酵母细胞分裂的机制和调控
- 批准号:
6781734 - 财政年份:1999
- 资助金额:
$ 33.93万 - 项目类别:
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