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Core B

核心B

基本信息

批准号：
9149705
负责人：
SUZANNE J BAKER
金额：
$ 15.57万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9149705
关键词：
Affect Binding Bioinformatics Biological Assay Biological Process Biometry Brain ChIP-seq Childhood Brain Neoplasm Childhood Cancer Genome Project Chromatin Comparative Genomic Analysis Computational Biology DNA Methylation Data Data Analyses Data Quality Data Set Encyclopedia of DNA Elements Ensure Epigenetic Process Gene Expression Genetic Genomics Glioma High Performance Computing Histones Human Lesion Metadata Methods Methylation Molecular Profiling Mus Neoplasms Occupations Pattern Primary Neoplasm Principal Investigator Program Research Project Grants Recurrence Reproducibility Research Infrastructure Research Project Grants Resources Saint Jude Children&apos s Research Hospital Scientist Services The Cancer Genome Atlas Transcriptional Regulation Transposase Universities Washington Work analytical tool base bisulfite sequencing chromatin modification data management data sharing epigenomics exome sequencing genomic data histone modification medulloblastoma methylation pattern mouse model next generation sequencing novel programs relational database transcriptome sequencing transcriptomics tumor tumor xenograft whole genome

项目摘要

The Bioinformatics Core is responsible for providing high-quality genomic and epigenomic data analysis for the four research projects outlined in this Program, for developing infrastructure for cross-project data sharing, and for identifying important biological processes involved in the initiation and progression of glioma and medulloblastoma by integrating cross-project genomic data sets, and for comparing data from the Program Project Grant with the extensive data resource generated by the other large-scale genomic projects including St. Jude/Washington University Pediatric Cancer Genome Project (PCGP), The Encyclopedia of DNA Elements (ENCODE) and The Cancer Genome Atlas Project (TCGA). Core B has access to state of art computing infrastructure at the St. Jude High Performance Computing Facility (HPCF) as well as analytical tools, computational pipeline and data management infrastructure established at the Department of Computational Biology. Core B will be responsible for analyzing data generated from the Program Project including exome sequencing, RNA-Seq, whole-genome bisulfite sequencing (WGBS), ChIP-Seq, Assay for Transposase-Accessible Chromatin using sequencing (ATAC-Seq) and methylation array. We will apply the most advanced public methods as well as novel methods developed by the Department of Computational Biology or the Biostatistics Department. We will also provide biostatistical expertise for all projects.

生物信息学核心负责为研究人员提供高质量的基因组和表观基因组数据分析。本计划中概述的四个研究项目，用于开发跨项目数据共享的基础设施，以及用于鉴定参与神经胶质瘤的起始和进展的重要生物学过程，通过整合跨项目基因组数据集，并比较来自该计划的数据，利用其他大型基因组项目产生的广泛数据资源，包括圣裘德/华盛顿大学儿科癌症基因组计划（PCGP），DNA百科全书 Elements（ENCODE）和癌症基因组图谱计划（TCGA）。核心B可访问最新技术圣裘德高性能计算设施（HPCF）的计算基础设施以及分析在该部建立的工具、计算管道和数据管理基础设施计算生物学核心B将负责分析从计划项目生成的数据包括外显子组测序、RNA-Seq、全基因组亚硫酸氢盐测序（WGBS）、ChIP-Seq、使用测序（ATAC-Seq）和甲基化阵列的转座酶可扩增染色质。我们将应用最先进的公共方法以及计算科学部开发的新方法生物学或生物统计学系。我们还将为所有项目提供生物统计专业知识。