Translational Core

翻译核心

• 批准号: 9269562
• 负责人: Kisha A Mitchell
• 金额: $ 13.49万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9269562
• 关键词: Address; Animal Model; Archives; Award; Biological; Calcium; Cell model; Chronic; Clinical Data; DNA; Data; Gene Proteins; Genetic Materials; Hepatocyte; Liver; Liver diseases; Pathologist; Pathology; Patients; Program Research Project Grants; Protocols documentation; Publications; Regulation; Research; Sample Size; Serum; Specimen; Specimen Handling; Tissues; Work; clinically relevant; human tissue; interest; liver biopsy; liver injury; patient oriented; patient registry; power analysis; response

PROJECT SUMMARY/ABSTRACT The purpose of the Translational Core (Core D) is to provide access to human tissue, genetic material, clinical data, and statistical support to determine the clinical relevance of the biological questions being investigated in the projects of this Program Project Grant. Archived liver biopsies stored by the Department of Pathology plus the Yale Liver Center's patient registry and serum, DNA and tissue specimens will be available, which in total represents specimens and/or patient data from nearly 20,000 unique patients. The Core's Liver Pathologist and Research Coordinator will work with the Project Leaders to identify, retrieve and interpret relevant bio- specimens and handle necessary IRB protocols. The Core's statistician will work with the Project Leaders and Translational Core staff to address power analyses, sample sizes, and other relevant statistical considerations. This core will enable each Project Leader to relate their basic observations in cells and animal models to changes in expression and tissue localization of the corresponding genes and proteins of interest in patients under normal conditions and in specific liver disease states.

项目摘要/摘要 翻译核心（核心D）的目的是提供对人体组织，遗传物质，临床的访问权限 数据和统计支持，以确定正在研究的生物学问题的临床相关性 该计划项目赠款的项目。病理部存储的存档肝活检 耶鲁肝脏中心的患者注册表和血清，DNA和组织标本将提供，总共 代表来自近20,000名独特患者的标本和/或患者数据。核心的肝病学家 研究协调员将与项目负责人合作，以识别，检索和解释相关的生物 标本和处理必要的IRB协议。核心的统计学家将与项目负责人一起工作 转化核心人员解决功能分析，样本量和其他相关统计考虑因素。 该核心将使每个项目负责人能够将其在细胞和动物模型中的基本观察结果与 患者相应基因和感兴趣蛋白的表达和组织定位的变化 在正常情况下和特定的肝病状态下。