Environmental Determinants of Lupus among African Americans

非裔美国人狼疮的环境决定因素

• 批准号: 9354400
• 负责人: DIANE L KAMEN
• 金额: $ 17.24万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-19 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9354400
• 关键词: ARHGEF5 gene; Address; Affect; African American; Age; Americas; Autoantibodies; Autoimmune Diseases; Autoimmune Responses; Autoimmunity; Award; Biological Markers; Blood; Chronic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Communities; DNA; Data; Dedications; Development; Diagnosis; Diet; Disease; Educational Curriculum; Educational process of instructing; Ensure; Environment; Environmental Pollution; Environmental Risk Factor; Epitopes; Equilibrium; Etiology; Faculty; Feces; First Degree Relative; Food; Foundations; Frequencies; Funding; Future; Generations; Genes; Genetic; Genomics; Genotype; Goals; Grant; Health; Heavy Metals; Hour; Immune; Immune response; Incidence; Individual; Inflammatory; Intervention; Investigation; Island; K-Series Research Career Programs; Leadership; Longitudinal cohort; Lupus; Medical Students; Mentors; Metagenomics; Microbe; Modeling; Modification; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; Natural History; Operations Research; Participant; Pathogenesis; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Play; Population; Postdoctoral Fellow; Prevalence; Preventive; Prize; Production; Questionnaires; Recruitment Activity; Research; Research Personnel; Research Project Grants; Residencies; Rheumatology; Risk Factors; Role; Sampling; Sea; Severities; Smoking; Specificity; Structure; Students; Susceptibility Gene; Systemic Lupus Erythematosus; Talents; Taxonomy; Testing; Therapeutic; Time; Training; Trust; United States National Institutes of Health; Variant; Whole-Genome Shotgun Sequencing; Woman; Work; career; clinical development; cost; design; genetic variant; gut microbiome; gut microbiota; high throughput analysis; metagenome; microbial; microbial community; microbiome; next generation; patient oriented research; persistent organic pollutants; pre-clinical; public health relevance; risk variant; sex; trait; young woman

Project Description Dr. Kamen has devoted her career to conducting patient-oriented research in rheumatology with a focus on lupus and to mentoring the next generation of clinical investigators. Starting in residency, she has made continuous progress toward her goal of uncovering the natural history of autoimmune disorders in order to design preventive and therapeutic strategies around identified risk factors. While conducting highly interdisciplinary and collaborative research projects she has mentored 48 students, post-doctoral trainees and junior faculty. Dr. Kamen teaches medical students and residents as the co-Director of the Rheumatology Curriculum and oversees the clinical research operations as Director of Clinical Research for the Division of Rheumatology. Her dedication and track record for teaching and research mentoring were recognized in 2011 when she received the MUSC Developing Scholar Award and in 2012 when she received the Mary Betty Stevens Young Investigator Prize from the Lupus Foundation of America. This K24 Midcareer Investigator Award would ensure continued protected time for Dr. Kamen's research and mentoring. The proposed research project titled “Environmental Determinants of Lupus among African Americans” includes new aims which build upon ongoing work. This project explores the role of gut microbiota in the development of lupus-related autoimmunity. The proposed research has the strong support of the Sea Island Gullah African American community, with whom we have an established ongoing longitudinal cohort and a community-academic partnership. Participants for the proposed research project will be recruited from the existing ongoing longitudinal SLE in Gullah Health (SLEIGH) study to take advantage of genetic and clinical data already collected since the study's inception in 2003. Dr. Kamen's investigations have been continuously NIH funded, including a 5-year K23 Career Development Award from NIAMS that led to a 4-year R21 from NIEHS and a 5-year P60 project from NIAMS under Dr. Kamen's leadership. The vast amount of accumulated past exposure data, wealth of existing stored biospecimens, and enthusiasm from study participants to take part in a study of an autoimmune disease common in their community, present a unique opportunity to address the role of the gut microbiota in the development of autoimmunity.

项目描述 博士Kamen致力于开展以患者为导向的风湿病学研究，重点是 并指导下一代临床研究人员。从实习开始，她就 不断朝着她的目标，揭示自身免疫性疾病的自然史， 围绕确定的风险因素设计预防和治疗策略。在进行高度 跨学科和合作研究项目，她已经指导了48名学生，博士后学员， 初级教员。卡门博士教医学生和居民作为流变学的共同主任 课程，并作为临床研究总监监督临床研究操作， 流变学她在教学和研究指导方面的奉献精神和记录在2011年得到了认可 当她获得了MUSC发展学者奖，并在2012年，当她收到了玛丽贝蒂 美国狼疮基金会史蒂文斯青年研究者奖。K24职业中期调查员 该奖项将确保卡门博士的研究和指导继续受到保护。 拟议的研究项目名为“非裔美国人狼疮的环境决定因素”， 包括建立在正在进行的工作基础上的新目标。该项目探讨了肠道微生物群在 狼疮相关自身免疫的发展。所提出的研究得到了海岛的大力支持 Gullah非裔美国人社区，我们与他们建立了一个持续的纵向队列和一个 社区-学术伙伴关系。建议研究项目的参与者将从 Gullah Health（SLEIGH）现有正在进行的纵向SLE研究， 自2003年研究开始以来已经收集的数据。卡门博士的研究一直在 NIH资助，包括NIAMS的5年K23职业发展奖，导致4年R21 NIEHS和一个5年的P60项目从NIAMS在卡门博士的领导。大量的积累 过去的暴露数据、大量现有储存的生物标本以及研究参与者的热情， 参与他们社区中常见的自身免疫性疾病的研究，提供了一个独特的机会来解决 肠道微生物群在自身免疫发展中的作用。