Environmental Determinants of Lupus among African Americans

项目说明 卡门博士致力于风湿病学方面以患者为导向的研究，重点是 并指导下一代临床研究人员。从住院医生开始，她取得了 她不断朝着发现自身免疫性疾病的自然历史的目标前进，以便 围绕已确定的风险因素设计预防和治疗策略。同时进行了高度的 她指导了48名学生、博士后实习生和 初级教员。卡门博士作为风湿病联合主任教授医学生和住院医生 课程设置，并作为临床研究总监监督临床研究业务 风湿病。她在教学和研究指导方面的奉献精神和业绩记录在2011年得到认可 当她获得MUSC发展学者奖时，她在2012年获得玛丽·贝蒂奖 史蒂文斯青年研究员奖，来自美国狼疮基金会。这位K24职业生涯中期调查员 该奖项将确保卡门博士的研究和指导得到持续的保护时间。 拟议的研究项目名为“非裔美国人中红斑狼疮的环境决定因素” 包括建立在正在进行的工作基础上的新目标。这个项目探索了肠道微生物区系在 狼疮相关自身免疫的研究进展。这项拟议的研究得到了海岛的大力支持 古拉非裔美国人社区，我们与他们建立了持续的纵向队列和 社区-学术合作伙伴关系。拟议研究项目的参与者将从 现有正在进行的古拉健康(雪橇)纵向系统性红斑狼疮研究利用遗传和临床优势 自2003年该研究开始以来已经收集的数据。卡门博士的调查一直在进行 NIH资助，包括NIAMS颁发的为期5年的K23职业发展奖，该奖项导致从 NIEHS和NIAMS在卡门博士的领导下进行的一个为期5年的P60项目。积累了大量的 过去的暴露数据，现有储存的生物标本的财富，以及研究参与者对采取 对他们社区中常见的一种自身免疫性疾病的研究提供了一个独特的机会来解决 肠道微生物区系在自身免疫发展中的作用。

Project Description Dr. Kamen has devoted her career to conducting patient-oriented research in rheumatology with a focus on lupus and to mentoring the next generation of clinical investigators. Starting in residency, she has made continuous progress toward her goal of uncovering the natural history of autoimmune disorders in order to design preventive and therapeutic strategies around identified risk factors. While conducting highly interdisciplinary and collaborative research projects she has mentored 48 students, post-doctoral trainees and junior faculty. Dr. Kamen teaches medical students and residents as the co-Director of the Rheumatology Curriculum and oversees the clinical research operations as Director of Clinical Research for the Division of Rheumatology. Her dedication and track record for teaching and research mentoring were recognized in 2011 when she received the MUSC Developing Scholar Award and in 2012 when she received the Mary Betty Stevens Young Investigator Prize from the Lupus Foundation of America. This K24 Midcareer Investigator Award would ensure continued protected time for Dr. Kamen's research and mentoring. The proposed research project titled “Environmental Determinants of Lupus among African Americans” includes new aims which build upon ongoing work. This project explores the role of gut microbiota in the development of lupus-related autoimmunity. The proposed research has the strong support of the Sea Island Gullah African American community, with whom we have an established ongoing longitudinal cohort and a community-academic partnership. Participants for the proposed research project will be recruited from the existing ongoing longitudinal SLE in Gullah Health (SLEIGH) study to take advantage of genetic and clinical data already collected since the study's inception in 2003. Dr. Kamen's investigations have been continuously NIH funded, including a 5-year K23 Career Development Award from NIAMS that led to a 4-year R21 from NIEHS and a 5-year P60 project from NIAMS under Dr. Kamen's leadership. The vast amount of accumulated past exposure data, wealth of existing stored biospecimens, and enthusiasm from study participants to take part in a study of an autoimmune disease common in their community, present a unique opportunity to address the role of the gut microbiota in the development of autoimmunity.