Genetic factors controlling the intensity of social behavior
Genetic factors controlling the intensity of social behavior
批准号:
9330873
负责人:
KENTA ASAHINA
金额:
$48.5万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-11 至 2021-05-31
关键词:
AffectAggressive behaviorAgonistic BehaviorAnimal ModelAnimalsArousalAutistic DisorderBehaviorBehavior ControlBehavioralCarbon DioxideComplexConflict (Psychology)Cyclic AMP-Dependent Protein KinasesDiseaseDisease modelDrosophila genusDrosophila melanogasterElementsEndocrine systemEnvironmentEtiologyExhibitsFMRFamideFoundationsG-Protein-Coupled ReceptorsGenesGeneticGenetic VariationGoalsHumanHungerIndividualKnowledgeLabelLightMental disordersMolecularMutationNeurodegenerative DisordersNeuromodulatorNeuronsNeuropeptidesOutputPatientsPhenotypePhysiologicalPopulationPost-Traumatic Stress DisordersProcessRNA interference screenReactionResearchResearch PersonnelSchizophreniaSignal TransductionSleepSocial BehaviorSocial EnvironmentSocial InteractionStudy modelsSystemTachykininTextTranscription Repressor/CorepressorTweensViolenceWorkbasecell typefeedingflygenetic elementgenome wide association studynervous system disorderneural circuitpromoterreceptorrelating to nervous systemresponsevinegar fly
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
To engage in productive social interactions, an animal must modulate its behavior based on the current situa-
tion. Neural and genetic factors regulating homeostatic behaviors (e.g., feeding and sleeping) have been well
studied, but the genetic mechanisms by which social behaviors are adjusted remain largely unexplored. Social
behaviors are intrinsically more complex than homeostatic behaviors, because in a social context an animal
must take into account its own internal state (e.g., hunger, arousal), as well as the reactions and perceived in-
tentions of the other individual. Understanding how behavior-related neural circuits are modulated in these con-
texts may shed light on human neural disorders that compromise patients' ability to interact with others (e.g.,
schizophrenia and autism). To identify genetic elements that correlate with behavioral phenotypes, genome-
wide association studies have been performed involving patients with psychiatric disorders or animal models.
Results from these approaches have been difficult to interpret, however, because: (1) most identified mutations
had a small effect, 2) causality between mutation and behavioral phenotype often could not be established,
and 3) mutations generally did not involve neuromodulators and neurohormonal systems known to control
these processes. To develop more direct approaches for tackling this problem, researchers have turned to
Drosophila melanogaster, which exhibits a rich repertoire of stereotypical social behaviors. The Drosophila sys-
tem allows for precise genetic alterations, and the labeling and functional manipulation of specific cell types,
making it an attractive model for studying how genes control behavioral choice by affecting specific neuronal
populations. Research into fly agonistic behavior has been particularly informative, as specific neurons ex-
pressing the neuropeptide tachykinin, which functions as a neuromodulator, have been shown to promote ag-
gression. However, elements that dampen aggression levels have not been found. Using an RNAi screening
approach, five genes that negatively regulate aggression were identified. Proposed research aims to elucidate
the molecular mechanisms by which these genes control the intensity of agonistic interactions. These genes
encode: (1) the neuropeptide FMRFamide, which may function as a neuromodulator to suppress agonistic be-
havior, (2 and 3) PKA-R2 and nervy, which act downstream of G-protein coupled receptors and therefore may
regulate signaling of aggression-promoting neuromodulators such as tachykinin, (4) TBPH, a transcriptional
repressor implicated in neurodegenerative diseases, and (5) Gr21a, a CO2 co-receptor. Finally, interplay be-
tween these negative regulators of aggression and known aggression promoters will be studied. As previous
work on the genetics of Drosophila aggression has consistently identified genes that regulate mammalian ag-
gression, the proposed project promises to illuminate genetic and neuronal networks that dynamically regulate
agonistic interaction across animal phyla. Such knowledge will fill critical gap in our understanding about how
genes influence social behaviors through specific neurons and circuits.
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会议论文
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
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批准号:9890786
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项目类别:
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资助金额:$41.23万
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财政年份:2017
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负责人:KENTA ASAHINA
-
依托单位:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
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批准号:10132286
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项目类别:
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资助金额:$41.23万
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财政年份:2017
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负责人:KENTA ASAHINA
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依托单位:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
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批准号:10668875
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项目类别:
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资助金额:$51.16万
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财政年份:2017
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负责人:KENTA ASAHINA
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依托单位:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
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批准号:9311836
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项目类别:
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资助金额:$41.23万
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财政年份:2017
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负责人:KENTA ASAHINA
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依托单位:
Genetic factors controlling the intensity of social behavior
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批准号:10799472
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项目类别:
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资助金额:$7.2万
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财政年份:2016
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负责人:KENTA ASAHINA
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依托单位:
Genetic factors controlling the intensity of social behavior
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批准号:10413011
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项目类别:
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资助金额:$48.93万
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财政年份:2016
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负责人:KENTA ASAHINA
-
依托单位:
Genetic factors controlling the intensity of social behavior
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批准号:10634758
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项目类别:
-
资助金额:$48.93万
-
财政年份:2016
-
负责人:KENTA ASAHINA
-
依托单位:
Genetic factors controlling the intensity of social behavior
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批准号:10207243
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项目类别:
-
资助金额:$48.93万
-
财政年份:2016
-
负责人:KENTA ASAHINA
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依托单位:
海外基金