Genetic factors controlling the intensity of social behavior

控制社会行为强度的遗传因素

基本信息

  • 批准号:
    10413011
  • 负责人:
  • 金额:
    $ 48.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-11 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The overarching goal of the Asahina lab is to understand the neurogenetic mechanisms by which animals ad- just tactics during social behaviors in a context-dependent manner. To this end, they study agonistic interac- tions between Drosophila melanogaster fruit flies. Flies choose between different types and intensities of social behaviors based on both internal and external conditions (e.g., feeding status, mating status, outcomes of pre- vious interactions). Powerful tools for manipulating gene and neuronal function in Drosophila with high preci- sion provides a unique platform for understanding the neurogenetic mechanisms underlying this rich behavioral flexibility. One major finding from the Asahina lab during the past 4 years is that a specific subset of octopamin- ergic neurons suppress aggression, and that the transcriptional regulator nervy controls the expression of genes necessary for these neurons to function as an aggression “brake”. They also characterized the genetic origins of the functional differences between three male-specific aggression-promoting neurons. With the ability to genetically control previously characterized aggression-promoting neurons and their development of novel computational methodologies for characterizing agonistic interactions at fine resolution, goals of the Asahina lab over the next five years are to: 1) elucidate how animals establish dominant-submissive hierarchies based on experience, and 2) characterize the neuronal and genetic mechanisms by which deficits in specific nutrients modulate behavioral tactics during competition for food. The first goal will be pursued by building upon their recent finding that the dominant-submissive relationship can override experimental activation of aggression- promoting neurons. They will test the prediction that experience-dependent modulation of aggressive behav- iors is implemented by an uncharacterized neuronal or molecular mechanism. The second goal is inspired by their finding that amino-acid deprivation dramatically increases aggression in both male and female flies, but only when live yeast is present in the environment. They will elucidate how specific nutrition deficits alter the function of aggression-controlling neuronal and genetic modules. These studies build upon strengths of the lab in genetics and advanced behavioral quantification, plus their ingenuity in developing novel behavioral para- digms for addressing longstanding questions in the field of animal behavior, most importantly: how do animals strategically choose between behavioral options? Theoretical analyses have predicted that animals must have evolved sophisticated mechanisms to integrate information and calculate costs and benefits associated with a particular behavior during agonistic interactions. However, experimental systems to quantitatively characterize the neural bases of these behavioral choices have remained elusive. The proposed experiments provide entry points for solving this problem by re-defining functions of genes and neurons from the perspective of cost/ben- efit calculations during competition. Proposed research will bridge this critical gap by illuminating operational principles by which genes and neurons control context-dependent adjustment of social behaviors.
项目摘要 Asahina实验室的首要目标是了解动物AD的神经发生机制, 在社会行为中以一种依赖于上下文的方式使用策略。为此,他们研究了竞争性相互作用- 果蝇之间的关系。苍蝇在不同类型和强度的社会性 基于内部和外部条件的行为(例如,饲养状况、交配状况、预处理结果 可见的相互作用)。高精度操纵果蝇基因和神经元功能的强大工具 锡永提供了一个独特的平台,用于了解这种丰富的行为背后的神经遗传机制。 灵活性.在过去的4年里,Asahina实验室的一个主要发现是章鱼胺的一个特定子集- 能神经元抑制攻击性,转录调节因子nervy控制 这些神经元发挥攻击性“刹车”功能所必需的基因。他们还描述了基因的特征, 三种男性特有的攻击促进神经元之间的功能差异的起源。有能力 基因控制先前表征的攻击促进神经元及其新的 在精细分辨率下表征激动相互作用的计算方法,Asahina的目标 在未来五年的实验室是:1)阐明动物如何建立支配-服从等级, 2)描述特定营养素缺乏的神经和遗传机制 在争夺食物时调整行为策略。第一个目标将通过建立在他们的基础上来实现。 最近的研究发现,支配-服从关系可以覆盖实验中的攻击性激活- 促进神经元。他们将测试攻击性神经元的经验依赖性调节的预测, IORS通过未表征的神经元或分子机制实现。第二个目标的灵感来自于 他们的发现是,氨基酸的缺失会显著增加雄性和雌性果蝇的攻击性, 只有当活酵母存在于环境中时。他们将阐明特定的营养缺乏如何改变 攻击控制神经元和遗传模块的功能。这些研究建立在实验室的优势之上 在遗传学和先进的行为量化,加上他们在开发新的行为帕拉, 在动物行为领域解决长期存在的问题,最重要的是:动物如何 策略性地在行为选择中做出选择理论分析预测,动物必须 发展了复杂的机制,以整合信息并计算与 在对抗性互动中的特殊行为。然而,定量表征的实验系统 这些行为选择的神经基础仍然难以捉摸。这些实验提供了进入 通过从成本/收益的角度重新定义基因和神经元的功能来解决这个问题的要点。 在竞争中计算。拟议的研究将通过阐明可操作性来弥合这一关键差距 基因和神经元控制社会行为的情境依赖性调整的原理。

项目成果

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KENTA ASAHINA其他文献

KENTA ASAHINA的其他文献

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{{ truncateString('KENTA ASAHINA', 18)}}的其他基金

Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
控制化学感觉诱导行为的微电路肽能神经调节
  • 批准号:
    9890786
  • 财政年份:
    2017
  • 资助金额:
    $ 48.93万
  • 项目类别:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
控制化学感觉诱导行为的微电路肽能神经调节
  • 批准号:
    10132286
  • 财政年份:
    2017
  • 资助金额:
    $ 48.93万
  • 项目类别:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
控制化学感觉诱导行为的微电路肽能神经调节
  • 批准号:
    10668875
  • 财政年份:
    2017
  • 资助金额:
    $ 48.93万
  • 项目类别:
Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors
控制化学感觉诱导行为的微电路肽能神经调节
  • 批准号:
    9311836
  • 财政年份:
    2017
  • 资助金额:
    $ 48.93万
  • 项目类别:
Genetic factors controlling the intensity of social behavior
控制社会行为强度的遗传因素
  • 批准号:
    10799472
  • 财政年份:
    2016
  • 资助金额:
    $ 48.93万
  • 项目类别:
Genetic factors controlling the intensity of social behavior
控制社会行为强度的遗传因素
  • 批准号:
    9330873
  • 财政年份:
    2016
  • 资助金额:
    $ 48.93万
  • 项目类别:
Genetic factors controlling the intensity of social behavior
控制社会行为强度的遗传因素
  • 批准号:
    10634758
  • 财政年份:
    2016
  • 资助金额:
    $ 48.93万
  • 项目类别:
Genetic factors controlling the intensity of social behavior
控制社会行为强度的遗传因素
  • 批准号:
    10207243
  • 财政年份:
    2016
  • 资助金额:
    $ 48.93万
  • 项目类别:

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