3D Printed Surface Modified Porous Metal Coatings for Load-bearing Implants

用于承重植入物的 3D 打印表面改性多孔金属涂层

• 批准号: 9314997
• 负责人: AMIT BANDYOPADHYAY
• 金额: $ 38.1万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-16 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9314997
• 关键词: 3D Print; Affinity; Alloys; Biological; Bone Tissue; Cells; Chemicals; Deposition; Devices; Dimensions; Distal; Elasticity; Evaluation; Failure; Fatigue; Femur; Goals; Gold; HA coating; Human; Implant; In Vitro; Infiltration; Lasers; Location; Measures; Mechanics; Medical; Metallurgy; Metals; Methods; Modeling; Modification; Modulus; Nanotubes; Oryctolagus cuniculus; Osseointegration; Osteoblasts; Osteoclasts; Oxygen; Patients; Performance; Physiological; Polymers; Porosity; Printing; Process; Property; Rattus; Research; Resistance; Route; Sampling; Structure; Surface; Surface Properties; Tantalum; Techniques; Temperature; Testing; Time; Tissues; Titanium; Weight-Bearing state; Work; base; biomaterial compatibility; bone; bone preservation; carbon skeleton; cost; density; design; improved; in vivo; innovation; interfacial; melting; nano; nanoscale; operation; programs; public health relevance; success; surface coating; vapor

 DESCRIPTION (provided by applicant): Though non-cemented implants are becoming popular among both traditional and younger patients, a key challenge still remains with these implants i.e., early stage osseointegration. Porous metal coated implants take longer time to bond with the surrounding bone tissue than cemented implants. Moreover, current manufacturing practices for porous metal coating results in a weak interface between the coating and the implant as evidenced from many recalls of coated implants due to interface failures. Our application is focused on surface modified three dimensionally printed (3DP) porous tantalum (Ta) and titanium (Ti) coating for load- bearing implants to improve early-stage osseointegration abilities. Both Ta and Ti have excellent biocompatibility and are safe to use in vivo. The low modulus of elasticity of porous coatings allow for better physiologic load transfer and relative preservation of bone stock. The objective of this proposed research is to test our central hypothesis, which is porous surface modified 3D printed Ta or Ti coating on Ti can enhance early stage in vivo tissue integration ability in load-bearing implants. The rationale is that once we delineate the effect of porosity and surface modification along with mechanical, in vitro and in vivo biological properties, we can achieve fundamental information on tissue integration for porous Ta and Ti coated implants, and identify optimal material properties that can help us design bone replacement devices based on application needs. Our long range goal is to design and manufacture surface modified reliable porous Ta and Ti coatings with strong interfacial bonding to improve early stage osseointegration abilities that is comparable to bioactive HA coated implants (the gold standard). Our program has three specific aims - (1) To establish processing parameters for porous Ta and Ti coatings on medical grade commercial Ti6Al4V alloy using laser-based 3D printing; (2) To measure mechanical and in vitro biological properties of surface modified Ta- and Ti-coating on Ti6Al4V alloys; and (3) To measure in vivo biological properties of surface modified Ta- and Ti-coating on Ti6Al4V alloys. The success of our program lies with innovative and translational laser-based 3D printing of porous Ta and Ti coatings that will be safer to use due to reliable and mechanically strong interface with improved early-stage osseointegration ability because of both micro- and nano-scale surface modification.

 描述（由申请人提供）：尽管非骨水泥型植入物在传统和年轻患者中越来越流行，但这些植入物仍然存在一个关键挑战，即，早期骨整合。多孔金属涂层植入物与骨水泥型植入物相比，需要更长的时间与周围骨组织结合。此外，多孔金属涂层的当前制造实践导致涂层和植入物之间的界面较弱，这一点从许多因界面失效而召回的涂层植入物中得到了证明。我们的应用集中于用于承重植入物的表面改性三维打印（3DP）多孔钽（Ta）和钛（Ti）涂层，以提高早期骨整合能力。Ta和Ti均具有良好的生物相容性，在体内使用安全。多孔涂层的低弹性模量允许更好的生理负荷转移和骨量的相对保存。这项拟议研究的目的是检验我们的中心假设，即多孔表面改性的3D打印Ta或Ti涂层可以增强承重植入物的早期体内组织整合能力。其基本原理是，一旦我们描述了孔隙率和表面改性沿着的机械、体外和体内生物学特性的影响，我们就可以获得多孔Ta和Ti涂层植入物组织整合的基本信息，并确定最佳材料特性，以帮助我们根据应用需求设计骨置换器械。我们的长期目标是设计和制造具有强界面结合的表面改性可靠多孔Ta和Ti涂层，以改善早期骨整合能力，与生物活性HA涂层植入物（金标准）相当。 我们的计划有三个具体目标-（1）使用基于激光的3D打印建立医用级商业Ti6 Al 4V合金上多孔Ta和Ti涂层的工艺参数;（2）测量Ti6 Al 4V合金上表面改性Ta和Ti涂层的机械和体外生物学性能;（3）测量Ti6 Al 4V合金上表面改性Ta和Ti涂层的体内生物学性能。我们计划的成功在于多孔Ta和Ti涂层的创新和基于激光的平移3D打印，由于可靠和机械强度高的界面，由于微米和纳米尺度的表面改性，早期骨整合能力得到改善，因此使用起来更安全。