Psychoneurological Symptoms in Situationally Stressed Low Income Mothers

处于情境压力的低收入母亲的心理神经症状

• 批准号: 9393384
• 负责人: Rebecca Salomon
• 金额: $ 3.5万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9393384
• 关键词: Address; Applied Research; Behavioral; Behavioral Research; Biological; Biological Markers; Breast; Characteristics; Child; Child Behavior; Child Development; Chronic; Chronic Disease; Complex; Data; Data Analyses; Data Set; Depressed mood; Development; Disease; Economic Burden; Economics; Emotional; Exposure to; Fatigue; Fibromyalgia; Foundations; Future; Goals; Health; Impaired cognition; Impairment; Individual; Infant; Intervention; Knowledge; Lead; Link; Low Income Population; Low income; Methods; Mothers; Neurologic; Neurosciences; North Carolina; Outcome; Pain; Parents; Pathway interactions; Physical Function; Population; Population Heterogeneity; Poverty; Quality of life; Regression Analysis; Reporting; Research; Resources; Role; Sampling; Sleep disturbances; Social Environment; Social Functioning; Societies; Stress; Subgroup; Symptoms; System; Toddler; Training; Treatment Efficacy; United States; Universities; Variant; Woman; associated symptom; cancer therapy; chronic pain; cost; cytokine; depressive symptoms; disturbance in affect; experience; functional status; health disparity; hypothalamic-pituitary-adrenal axis; improved; improved outcome; innovation; lifestyle factors; lifetime risk; member; monoamine; motherhood; multidisciplinary; neurotransmission; novel strategies; reduce symptoms; secondary analysis; skills; stressor; symptom management; symptom science

Project Summary/Abstract In the United States, more than 10% of mothers, or 8.5 million, live in poverty, placing the mothers in conditions of chronic situational stress. Low income mothers are exposed to chronic situational stress, due in part to the economic hardship and additional stressors associated with the responsibilities of motherhood. Exposure to economic hardship is associated with higher reports of pain, fatigue, sleep disturbance, depressed mood, and cognitive dysfunction, known as the psychoneurological symptoms. These symptoms can significantly impair a mother by interfering with her ability to function and mother. Compromises to a mother's functioning places her children at higher lifetime risks of impaired cognitive and emotional development; infants and toddlers are the most vulnerable to these consequences. To date, attempts to intervene on situational stress-related symptoms in low income mothers have focused on depressive symptoms. These interventions have met with varied levels of efficacy. The limited efficacy may be because interventions addressing depressive symptoms do not include pain, which is experienced by 50% of low income mothers. An alternative and novel approach is to reconceptualize the stress-related symptoms as psychoneurological symptoms in order to consider underlying biological mechanisms that could be targeted by interventions. The proposed study will describe psychoneurological symptoms in a sample of low income mothers under chronic situational stress and determine the associations of the symptoms with situational stress and with maternal and child outcomes. This study will be a secondary analysis of data from 356 low income mothers and will combine the data from two parent studies conducted at the University of North Carolina at Chapel Hill. The proposed study will analyze key variables of situational stress, psychoneurological symptoms, maternal functioning, and child behavior and development. The project has three aims: to describe the intensity of the psychoneurological symptoms by comparing a simple, data-naïve approach (composite score) against a complex, innovative data-driven approach (reduced rank regression); to use multiple regression analyses to explore how variations in levels of chronic situational stress are associated with intensity of psychoneurological symptoms; and to use multiple regression analyses to determine the relationship of psychoneurological symptoms to mother's functional status (physical functioning, social functioning, role functioning, mothering) and child behavioral and developmental status. This study addresses NINR's Innovative Questions in Symptom Science concerning the impact of adverse symptoms across diverse populations by researching the behavioral dynamics of symptoms (1-1) and how lifestyle factors and environmental conditions impact symptoms (1-3). The findings from this study will be the first step towards determining personalized biomarkers of psychoneurological symptoms and, eventually, developing targeted symptom management interventions to improve quality of life for the mothers.

项目总结/摘要 在美国，超过10%的母亲，即850万人，生活在贫困之中， 慢性情境压力低收入母亲长期面临环境压力， 部分原因是经济困难和与母亲责任有关的额外压力。 暴露于经济困难与疼痛，疲劳，睡眠障碍，抑郁 情绪和认知功能障碍，被称为心理神经症状。这些症状可能 通过干扰母亲的功能和母亲的能力而严重损害母亲。对母亲的妥协 功能使她的孩子在认知和情感发育受损的一生中面临更高的风险;婴儿 而蹒跚学步的孩子最容易受到这些后果的影响。到目前为止，试图干预局势， 低收入母亲的压力相关症状集中在抑郁症状上。这些干预措施 都有不同程度的效果疗效有限可能是因为干预措施解决了 抑郁症状不包括疼痛，50%的低收入母亲经历过疼痛。一个替代 新的方法是将压力相关症状重新概念化为心理神经症状， 以便考虑干预措施可能针对的潜在生物机制。 这项拟议的研究将描述一个样本的低收入母亲的心理神经症状， 慢性情境压力，并确定症状与情境压力和 产妇和儿童的结果。本研究将对356位低收入母亲的数据进行二次分析 并将联合收割机的数据从两个家长在查佩尔山的北卡罗来纳州大学进行的研究。 这项研究将分析情境压力、心理神经症状、母亲的 功能，儿童行为和发展。该项目有三个目标：描述地震的强度 心理神经症状，通过比较一个简单的，数据幼稚的方法（综合评分）与 复杂、创新的数据驱动方法（降秩回归）;使用多元回归分析， 探索慢性情境压力水平的变化如何与心理神经学的强度相关 症状;并使用多元回归分析，以确定心理神经的关系， 症状与母亲的功能状态（身体功能、社会功能、角色功能、母性） 以及儿童行为和发育状况。 这项研究解决了NINR在症状科学中关于不良反应的影响的创新问题。 通过研究症状的行为动力学（1-1）以及如何在不同人群中发现症状， 生活方式因素和环境条件影响症状（1-3）。这项研究的结果将是 确定心理神经症状的个性化生物标志物的第一步，最终， 制定有针对性的症状管理干预措施，以改善母亲的生活质量。