Northeast Node of the National Drug Abuse Clinical Trials Network

国家药物滥用临床试验网络东北节点

• 批准号: 9274950
• 负责人: Lisa A. Marsch
• 金额: $ 74.84万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274950
• 关键词: Achievement; Adolescent; Adult; Alcohol or Other Drugs use; American; Analgesics; Behavioral; Caring; Chronic; Clinical; Clinical Trials Network; Collaborations; Communities; Community Networks; Comorbidity; Cost effectiveness research; Criminal Justice; Development; Disease; Drug abuse; Drug user; Effectiveness; Evaluation; Funding; Geographic Locations; HIV; HIV risk; Healthcare Systems; Home environment; Hospitals; Individual; Internet; Intervention; Knowledge; Leadership; Maine; Managed Care; Medical; Mental Health; Mental disorders; Modeling; National Clinical Trials Network; National Institute of Drug Abuse; New Hampshire; Operating System; Patients; Persons; Pharmaceutical Preparations; Pharmacology; Policies; Population; Practical trial; Prevention; Primary Health Care; Principal Investigator; Provider; Public Health; Recovery; Research; Research Infrastructure; Research Support; Resources; Risk; Risk Behaviors; Role; Rural; Rural Community; Rural Health; Sample Size; Sampling; Schools; Science; Seminal; Services; Site; Smoker; Substance Use Disorder; Substance abuse problem; System; Technology; Therapeutic; Time; Tranquilizing Agents; Vermont; Veterans; Work; Youth; addiction; adolescent substance use; aged; base; behavioral health; care systems; chronic pain; college; cost; effectiveness trial; evidence base; illicit drug use; implementation research; insight; marijuana use; medical specialties; opioid use disorder; payment; prescription opioid; primary care setting; programs; public health relevance; ranpirnase; research and development; science education; screening; substance abuse treatment; synergism; technology validation; therapy development; tool

 DESCRIPTION: We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 "Center of Excellence" that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectivenes, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth - both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.

 产品说明：我们建议建立一个新的NIDA临床试验网络（CTN）的节点-东北节点跨越新罕布什尔州，佛蒙特州和缅因州的农村社区。该节点将基于达特茅斯学院与几个大型提供商网络合作，涵盖400多个成人和/或青少年一般医疗保健合作伙伴，一系列成瘾专业计划和国家行为健康管理护理合作伙伴。达特茅斯是这个节点的理想家园，因为它也是NIDA资助的技术和行为健康中心（CTBH）的所在地，这是一个P30“卓越中心”，利用科学来告知技术（网络，移动的）的开发，评估和战略实施，基于技术的治疗工具针对物质使用障碍（SUD）和相关问题（包括艾滋病毒风险行为和精神病合并症）。CTBH由丽莎Marsch博士领导，她还将担任拟议CTN节点的主要研究者。我们的团队通过提高质量，成就的速度和科学研究的影响，专注于技术应用于SUD和行为健康治疗，引领了该领域。我们的团队在SUD干预开发的各个阶段都有专业知识，包括可行性，可接受性，有效性（包括多站点有效性试验），成本效益和在许多情况下的实施研究，包括成瘾和心理健康专业计划，医学专业计划，医院，学校，刑事司法环境和初级保健。这项工作包括关于将可持续发展的干预措施纳入农村保健系统的开创性研究。这项工作已经在广泛的人群中进行，包括慢性吸毒者、吸烟者、退伍军人、慢性疼痛患者、艾滋病毒高危人群以及同时发生SUD和精神疾病的人群。我们的小组在青年研究方面具有特殊的专业知识，包括青少年的筛查和评估，预防，治疗，康复支持和护理协调-包括专注于青少年大麻使用和处方阿片类药物使用障碍的几项研究。该提案的目的是（1）通过启动CTN东北节点，将NIDA CTN扩展到农村地区的新州，从而扩大我们与初级保健和其他社区治疗合作伙伴的合作，以识别和实施针对SUD的及时和重要试验，（2）支持和发展富有成效的研究议程，特别关注集中利用基于技术的工具和/或或优先关注青年--既在东北节点内，也通过在国家CTN社区内的领导和咨询作用，以及（3）发展和支持基础设施，以加强协同作用，支持CTBH和CTN之间的双向知识和资源共享。这些活动将为农村保健系统中与药物使用有关的需求和优先事项以及各种社区系统中基于技术的干预措施的有效性方面的关键科学发现和见解提供信息。