Northeast Node of the National Drug Abuse Clinical Trials Network

国家药物滥用临床试验网络东北节点

• 批准号: 9901399
• 负责人: Lisa A. Marsch
• 金额: $ 122.16万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901399
• 关键词: Achievement; Adolescent; Adult; Alcohol or Other Drugs use; American; Analgesics; Behavioral; Caring; Chronic; Clinical; Clinical Trials Network; Collaborations; Communities; Community Networks; Comorbidity; Cost effectiveness research; Criminal Justice; Development; Drug abuse; Drug user; Effectiveness; Evaluation; Funding; Geographic Locations; HIV; HIV risk; Healthcare Systems; Home environment; Hospitals; Individual; Infrastructure; Internet; Intervention; Knowledge; Leadership; Maine; Managed Care; Medical; Mental Health; Mental disorders; Modeling; National Clinical Trials Network; National Institute of Drug Abuse; New Hampshire; Persons; Pharmaceutical Preparations; Pharmacology; Policies; Population; Practical trial; Prevention; Primary Health Care; Principal Investigator; Public Health; Recovery; Research; Research Infrastructure; Research Support; Resources; Risk; Risk Behaviors; Role; Rural Community; Sample Size; Sampling; Schools; Science; Seminal; Services; Site; Smoker; Substance Use Disorder; Substance abuse problem; System; Technology; Therapeutic; Time; Tranquilizing Agents; Vermont; Veterans; Work; Youth; addiction; adolescent substance use; aged; base; behavioral health; care coordination; care systems; chronic pain patient; college; effectiveness trial; evidence base; illicit drug use; implementation research; insight; marijuana use; medical specialties; opioid use disorder; payment; prescription opioid; primary care setting; programs; provider networks; ranpirnase; research and development; rural area; rural healthcare; science education; screening; service delivery; substance abuse treatment; synergism; technology validation; therapy development; tool

Project Summary/Abstract We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 “Center of Excellence” that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectiveness, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth – both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.

项目摘要/摘要 我们建议建立NIDA临床试验网络(CTN)的一个新节点--东北节点 横跨新罕布夏州、佛蒙特州和缅因州的农村社区。此节点将基于 达特茅斯学院与几家大型提供商合作，覆盖400多名成年人和/或 青少年一般医疗护理伙伴，一系列成瘾专科项目，以及国家行为 健康管理型保健合作伙伴。达特茅斯是这个节点的理想家园，因为它也是NIDA的家乡- 资助的技术和行为健康中心(CTBH)，一个使用科学的P30“卓越中心” 为基于技术(网络、移动)的开发、评估和战略实施提供信息 针对物质使用障碍(SODS)和相关问题(包括艾滋病毒危险行为和 精神合并症)。CTBH由Lisa Marsch博士领导，她也将担任首席调查员 在拟议的CTN节点上。我们的团队通过提高质量、实现速度和 科学研究的影响集中在将技术应用于SUD和行为健康治疗。 我们的团队在SUD干预开发的所有阶段都有专业知识，从可行性、可接受性、 疗效、疗效-效果、效果(包括多点效果试验)、成本效益和 在许多情况下的执行研究，包括成瘾和心理健康专业方案、医疗 专科项目、医院、学校、刑事司法机构和初级保健。这项工作包括 将sud干预措施整合到农村卫生保健系统的开创性研究。这项工作已经完成了 在广泛的人群中进行，包括长期吸毒者、吸烟者、退伍军人、慢性疼痛 患者、艾滋病毒高危人群以及同时患有肥皂泡和精神疾病的人群。我们的团队已经 在青年研究方面的特殊专长，从筛查和评估、预防、治疗、 对青少年的康复支持和护理协调--包括以下几个方面的研究 青少年中的大麻使用和处方阿片使用障碍。这项建议的目的是(1)扩大 通过启动CTN的东北节点，将NIDA CTN扩展到农村地区的新州，从而 扩大我们与初级保健和其他社区治疗伙伴的合作，以确定和 及时实施针对肥胖症的重大试验，(2)支持和发展富有成效的研究议程 特别关注集中利用基于技术的工具和/或具有优先重点的CTN试验 关于青年--既在东北节点内，也通过在国家CTN中的领导和咨询作用 社区，以及(3)开发和支持基础设施，以增强协同效应并支持双向 CTBH和CTN之间的知识和资源共享。这些活动将使关键的科学研究 关于农村卫生保健系统中与物质使用相关的需求和优先事项的发现和见解 以及各种社区系统中以技术为基础的干预措施的有效性。