A Health IT based Psychoeducational Intervention for African American Prostate Cancer

描述（由申请人提供）：与白色男性相比，非裔美国人（AA）男性除了患前列腺癌和死于该疾病的风险增加外，诊断后生活质量（QOL）较差的风险也增加。以前的研究表明，新诊断的前列腺癌患者确实希望被告知，但患者仍然有未满足的信息需求。信息寻求已被证明在个人努力科普与癌症诊断和治疗相关的生活质量破坏方面发挥着关键作用。有充分的证据表明，AA获得推荐的前列腺癌教育的机会有限，并且在接受心理社会信息和服务方面遇到多重障碍。虽然越来越多的证据表明，心理教育干预措施可以改善新诊断的前列腺癌患者的生活质量，但仍然缺乏研究这些干预措施在AA中的疗效。更重要的是，前列腺癌焦虑和前列腺癌AA预后特征之间的关联尚未得到很好的研究。因此，前列腺癌焦虑与生活质量共同决定因素的关系仍然知之甚少。作为回应，我们开发了一种基于信息技术（IT）的心理教育干预，个性化健康信息导航（PHIN），以提高新诊断的前列腺癌患者的生活质量。这项以社区为基础的随机对照试验的目的是研究在新诊断为前列腺癌的AA男性中，为期6周的社区导航员（CN）指导的健康IT心理教育干预（PHIN）与印刷教育（PE）对QOL结局的影响。有资格参加这项研究的男性是年龄在18到75岁之间的AA男性，他们有活检证实的前列腺癌诊断。合格受试者将在Moffitt癌症中心（MCC）和位于坦帕湾地区的选定社区临床实践机构首次诊断后2个月内确定。在提供书面知情同意书后，将要求合格受试者完成基线电话访谈，并在基线评估后6周、3个月、6个月和12个月联系受试者进行随访电话访谈。将通过自我报告的数据和测量焦虑/压力相关生物标志物、皮质醇和端粒来证实改善的QOL。先前的研究报道，通过行为干预改善生活质量与端粒长度和皮质醇的变化相关。

DESCRIPTION (provided by applicant): For African American (AA) men, in addition to being at increased risk for developing prostate cancer and dying from this disease, they also have an increased risk of experiencing poorer quality of life (QOL) after diagnosis in comparison to white men. Previous studies have demonstrated that men with newly diagnosed prostate cancer do want to be informed, yet patients continue to have unmet information needs. Information seeking has been demonstrated to play a critical role in individuals' efforts to cope with the disruption of QOL associated with cancer diagnosis and treatment. It has been well documented that AAs have limited access to recommended prostate cancer education and experience multiple barriers to receiving psychosocial information and services. Although a growing body of evidence suggests that psychoeducational interventions improve QOL among newly diagnosed prostate cancer patients, there remains a lack of research examining the efficacy of these interventions among AAs. More so, associations between prostate cancer anxiety and prognostic features for prostate cancer among AA have not been well investigated. As a result, the relationship of prostate cancer anxiety to the common determinants of QOL remains poorly understood. In response, we developed an Information Technology (IT) based Psychoeducational intervention, Personalized Health Information Navigator (PHIN), to enhance QOL of newly diagnosed prostate cancer patients. The objectives of this community-based randomized control trial are to examine the impact on QOL outcomes of a six-week community navigator (CN) guided health IT psychoeducational intervention (PHIN) versus print education (PE) among AA men who are newly diagnosed with prostate cancer. Men eligible to participate in the study are AA men ages18 to 75 who have a biopsy-confirmed diagnosis of prostate cancer. Eligible subjects will be identified within 2-months of their initial diagnosis from the Moffitt Cancer Center (MCC) and select community-based clinical practices located in the Tampa Bay area. Following provision of written informed consent, eligible subjects will be asked to complete a baseline telephone interview and will be contacted for follow-up telephone interviews at 6-weeks, 3-, 6- and 12-months following the baseline assessment. The improved QOL will be confirmed by self-reported data and measuring anxiety/stress related biomarkers, cortisol and telomeres. Previous studies reported that improved QOL by behavioral interventions was associated with changes in telomere length and cortisol.