Frontiers: University of Kansas Clinical and Translational Science Institute

前沿：堪萨斯大学临床与转化科学研究所

• 批准号: 9514338
• 负责人: Richard J. Barohn
• 金额: $ 406.37万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-07 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9514338
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Contact PD/PI: Barohn, Richard Joel OVERALL: ABSTRACT Frontiers: The Heartland Institute for Clinical and Translational Research has been a catalyst for bringing together translational science investigators and stakeholders across the KC region, and beyond. Located at the University of Kansas Medical Center (KUMC) under the leadership of Dr. Barohn, our commitment to team science and multidisciplinary collaboration reaches beyond the walls of our academic health science center and promotes collaboration among investigators from diverse disciplines across local partner academic institutions and affiliated health care institutions. The vision of Frontiers is to contribute to and lead national efforts to transform the way we do clinical and translational research (CTR), and to ensure research is more rapidly and more efficiently translated to the point of care so that it may contribute to improved health. Specifically, Frontiers aims to: 1) Engage in bi-directional collaboration with all stakeholders to develop, demonstrate, and disseminate advances across the translational science spectrum that insures inclusion and integration of complex and diverse populations and individuals across the lifespan from birth to end of life; 2) Create a sustainable translational workforce of multi-disciplinary investigators, research personnel, and community and patient stakeholders in the use of translational science tools through innovative and creative programs; and 3) Strengthen institutional and regional infrastructure to accelerate translational research. We will accomplish these aims by drawing on our considerable strengths: a) developing informatics tools for making EHR data `research ready' and implementing clinic- and community-based registries for study recruitment and other translational research applications; b) nurturing and sustaining strong patient and community engagement relationships that will support research with African American, Latino, American Indian, LGBTQ, pediatric, geriatric, rare disease, prison, and rural populations; c) offering innovative training programs for the entire CTR workforce (not just investigators), including plans for comprehensive entrepreneurship and implementation research training and creating new team science brainstorming mechanisms that will lead to multidisciplinary discovery projects and d) advancing medical devices and re-purposed drugs to patients through novel strategies developed by Frontiers' Institute for Advancing Medical Innovations (IAMI)that is nationally known for its product development translational research and high impact collaborations with industry, academia, government, and disease philanthropy partners. All Frontiers units are linked by a group of Navigators that can be accessed by Frontiers investigative teams and community partners. These plans position Frontiers to contribute to goals, and lead initiatives of the CTSA network by building on technological, computational, and health/disease knowledge to advance translational research. Project Summary/Abstract Page 274 Contact PD/PI: Barohn, Richard Joel OVERALL NARRATIVE Frontiers: The Heartland Institute for Clinical and Translational Research provides infrastructure and educational programs to develop the next generation of CTR investigative teams. As a regional organization involving two states and three universities, Frontiers is able to blend the best resources available to advance team, community and clinical translational science. This results in accelerating discoveries and research findings that may be more rapidly brought to the point of care and contribute to population health.

联系PD/PI：Barohn，Richard Joel 总体：摘要 前沿：哈特兰临床和转化研究所一直是一个催化剂， 在整个KC地区及其他地区的转化科学研究人员和利益相关者一起。位于 在堪萨斯大学医学中心（KUMC）的Barohn博士的领导下，我们的承诺 团队科学和多学科合作超越了我们的学术健康的墙壁 科学中心，促进来自不同学科的研究人员在当地 伙伴学术机构和附属卫生保健机构。Frontiers的愿景是 领导国家努力改变我们进行临床和转化研究（CTR）的方式， 确保研究更迅速、更有效地转化到护理点，以便为 to improve改善health健康.具体而言，Frontiers的目标是：1）与所有人进行双向合作 利益相关者开发，展示和传播整个转化科学的进步 确保包容和整合复杂多样的人口和个人， 从出生到生命结束的寿命; 2）创建多学科的可持续翻译队伍 研究人员，研究人员，社区和患者利益相关者在使用翻译 通过创新和创造性的计划科学工具;和3）加强机构和区域 加快转化研究的基础设施。我们将通过利用我们的 相当大的优势：a）开发信息学工具，使EHR数据“为研究做好准备”， 为研究招募和其他转化研究实施基于诊所和社区的登记 B）培养和维持强大的患者和社区参与关系， 支持非裔美国人，拉丁美洲人，美洲印第安人，LGBTQ，儿科，老年人，罕见 疾病，监狱和农村人口; c）为整个CTR提供创新的培训计划 劳动力（不仅仅是调查人员），包括全面创业和实施计划 研究培训和创建新的团队科学头脑风暴机制，这将导致 多学科发现项目和d）推进医疗设备和患者重新使用的药物 通过前沿推进医学创新研究所（AAMI）开发的新策略， 以其产品开发转化研究和高影响力的合作而闻名于全国， 工业界、学术界、政府和疾病慈善合作伙伴。所有边境单位都由一个 Frontiers调查团队和社区合作伙伴可以访问的导航器组。 这些计划使Frontiers能够为目标做出贡献，并通过建立CTSA网络来领导CTSA网络的倡议。 技术，计算和健康/疾病知识，以推进转化研究。 项目摘要/摘要第274页 联系PD/PI：Barohn，Richard Joel 整体叙事 前沿：哈特兰临床和转化研究所提供基础设施和 教育计划，以发展下一代的CTR调查团队。作为一个区域组织 涉及两个州和三所大学，前沿是能够混合最好的资源，以促进 团队、社区和临床转化科学。这将加速发现和研究 这些发现可以更快地用于护理，并有助于人口健康。