SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

SPF 4 艾滋病研究恒河猴繁殖群

• 批准号: 9493113
• 负责人: Gregory Brion Timmel
• 金额: $ 16.88万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9493113
• 关键词: AIDS prevention; AIDS vaccine development; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Animals; Biomedical Research; Breeding; Caring; Disease; Ensure; Funding; Genetic Variation; Genetic screening method; Genotype; HIV; Health Sciences; Human; Immune system; Macaca; Macaca mulatta; Modeling; Oregon; Pathogenesis; Primates; Request for Applications; Research; Resources; SIV; Services; Testing; Universities; Vaccines; Viral; Work; design; germ free condition; offspring; pandemic disease; pathogen; programs; simian human immunodeficiency virus; vaccine development; vector vaccine

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development as well as other approaches for controlling AIDS are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Efficient domestic breeding programs, effectively managed to produce well characterized animals, with enhanced usefulness in biomedical research offer the best solution to ensuring the supply of Indian-origin rhesus macaques for AIDS vaccine development and other treatment and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

项目概要，总体 安全、有效的疫苗仍然是控制人体免疫缺陷病毒的最大希望 (HIV)流行病由于印度恒河猴（Macaca mulatta）和人类之间的相似性， 免疫系统、疫苗开发以及其他控制艾滋病的方法， 依赖于SIV和SHIV猕猴模型。对印度恒河猴的持续需求 猕猴来支持这项工作。高效的国内育种计划，有效地管理生产良好 特征化的动物，在生物医学研究中具有更高的实用性，为确保 为艾滋病疫苗开发和其他治疗及发病提供印度恒河猴 问题研究该提案的目的是为具有遗传特征的特定病原体提供支持 免费的，印度起源的恒河猴艾滋病研究群体资源，成立于2001年， 俄勒冈州国家灵长类动物研究中心。