Caging Solution for Macaques Assigned to AIDS Research projects Requiring Antiretroviral Therapy

为需要抗逆转录病毒治疗的艾滋病研究项目提供的猕猴笼养解决方案

• 批准号: 10404868
• 负责人: Gregory Brion Timmel
• 金额: $ 9.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404868
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adult; Animal Welfare; Animals; Area; Back; Blood; Body Weight; Categories; Collection; Floor; Funding; Future; Goals; Grant; Height; Housing; Infectious Diseases Research; Macaca; Oregon; Personal Satisfaction; Primates; Procedures; Research; Research Project Grants; Research Support; Resources; Socialization; Update; antiretroviral therapy; base; design; male; programs; restraint; social; square foot

PROJECT SUMMARY The U42 SPF4 grant at the Oregon National Primate Research Center (ONPRC) helps to support an active and highly productive HIV/AIDS research program. Significant increases in grant funding and the need for larger group sizes have strained the Center's resources, particularly space and caging. Therefore, additional caging is being requested to support this research by providing optimal long-term housing that better addresses the welfare of the animal subjects that are assigned to projects requiring daily antiretroviral therapy (ART). The ONPRC has multiple caging types, which can broadly be split into two categories: standard cages 32 inches in height with 4.5 sq. ft. of floor space and large cages 36 inches in height with 6- 6.5 sq. ft. of floor space. Larger, taller cages are better suited for promoting positive well-being, and are necessary for social housing adult males over 10kg. ART studies tend to be of long duration resulting in animals often exceeding 10 kg in body weight and therefore requiring the larger size caging. In addition, the cages being requested have been optimized for ease of administration of ART. There is an enlarged opening in the front that allows for the technician to more easily and safely inject the animal, and the squeeze-back mechanism has been refined, compared to older caging to provide better restraint during this procedure. These cages have also been designed to better facilitate the attachment of procedure cages that are used for blood collection. At the ONPRC there are currently 115 macaques assigned to AIDS related research requiring ART. Based on current projections, HIV/AIDS NHP assignments requiring ART could increase to 250 within the next year. The ONPRC is in significant need of new, updated caging for our NHP research areas. This new caging will support HIV/AIDS research by providing right-sized housing that is optimized for macaques requiring daily antiretroviral therapy. Nine one-over-one Socialization Racks (18 cages total) will be purchased to be placed in infectious disease research appropriate animal holding rooms.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC）的U42 SPF4赠款有助于支持活跃 以及高产的艾滋病毒/艾滋病研究计划。赠款资金的大幅增加和需要 较大的群体尺寸使该中心的资源尤其是空间和笼子。因此，其他 通过提供更好的长期住房，要求笼子来支持这项研究 解决分配给需要每日抗逆转录病毒治疗项目的动物受试者的福利 （艺术）。 ONPRC具有多种笼子类型，可以将其大致分为两类：标准笼32 高度为4.5平方英尺的地板空间，高度为36英寸，地板的高度为36英寸 空间。更大，更高的笼子更适合促进积极的福祉，对于社会来说是必要的 住房成年男性超过10公斤。艺术研究往往持续很长，导致动物通常超过10 体重的千克，因此需要更大的笼子。此外，被要求的笼子 优化了以易于管理艺术。正面有一个扩大的开口，可以 技术人员更容易，更安全地注入动物，并且已经完善了挤压机制， 与较旧的笼子相比，在此过程中提供更好的约束。这些笼子也是 旨在更好地促进用于血液收集的程序笼的附着。在 ONPRC目前有115个猕猴分配给需要艺术的艾滋病相关研究。基于当前 预测，需要艺术的艾滋病毒/艾滋病NHP分配可能会在明年内增加到250。 ONPRC非常需要为我们的NHP研究领域提供新的更新的笼子。这个新的笼子将 通过提供针对需要每日猕猴进行优化的右尺寸住房来支持艾滋病毒/艾滋病研究 抗逆转录病毒疗法。将购买九个单位的社会化架子（总计18个笼子） 传染病研究适当的动物持有室。