Caging Solution for Macaques Assigned to AIDS Research projects Requiring Antiretroviral Therapy

为需要抗逆转录病毒治疗的艾滋病研究项目提供的猕猴笼养解决方案

• 批准号: 10404868
• 负责人: Gregory Brion Timmel
• 金额: $ 9.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404868
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Adult; Animal Welfare; Animals; Area; Back; Blood; Body Weight; Categories; Collection; Floor; Funding; Future; Goals; Grant; Height; Housing; Infectious Diseases Research; Macaca; Oregon; Personal Satisfaction; Primates; Procedures; Research; Research Project Grants; Research Support; Resources; Socialization; Update; antiretroviral therapy; base; design; male; programs; restraint; social; square foot

PROJECT SUMMARY The U42 SPF4 grant at the Oregon National Primate Research Center (ONPRC) helps to support an active and highly productive HIV/AIDS research program. Significant increases in grant funding and the need for larger group sizes have strained the Center's resources, particularly space and caging. Therefore, additional caging is being requested to support this research by providing optimal long-term housing that better addresses the welfare of the animal subjects that are assigned to projects requiring daily antiretroviral therapy (ART). The ONPRC has multiple caging types, which can broadly be split into two categories: standard cages 32 inches in height with 4.5 sq. ft. of floor space and large cages 36 inches in height with 6- 6.5 sq. ft. of floor space. Larger, taller cages are better suited for promoting positive well-being, and are necessary for social housing adult males over 10kg. ART studies tend to be of long duration resulting in animals often exceeding 10 kg in body weight and therefore requiring the larger size caging. In addition, the cages being requested have been optimized for ease of administration of ART. There is an enlarged opening in the front that allows for the technician to more easily and safely inject the animal, and the squeeze-back mechanism has been refined, compared to older caging to provide better restraint during this procedure. These cages have also been designed to better facilitate the attachment of procedure cages that are used for blood collection. At the ONPRC there are currently 115 macaques assigned to AIDS related research requiring ART. Based on current projections, HIV/AIDS NHP assignments requiring ART could increase to 250 within the next year. The ONPRC is in significant need of new, updated caging for our NHP research areas. This new caging will support HIV/AIDS research by providing right-sized housing that is optimized for macaques requiring daily antiretroviral therapy. Nine one-over-one Socialization Racks (18 cages total) will be purchased to be placed in infectious disease research appropriate animal holding rooms.

项目总结 俄勒冈州国家灵长类研究中心(ONPRC)的U42 SPF4赠款有助于支持积极的 和高效的艾滋病毒/艾滋病研究计划。赠款资金大幅增加，需要 更大的群体规模使该中心的资源紧张，特别是空间和笼子。因此，额外的 要求CAGING通过提供更好的最佳长期住房来支持这项研究 解决分配给需要每日抗逆转录病毒治疗的项目的动物受试者的福利问题 (艺术)。 ONPRC有多种笼子类型，大致可以分为两类：标准笼子32 英寸高，4.5平方英尺英国《金融时报》占地面积和36英寸高、6-6.5平方英尺的大型笼子英国《金融时报》楼层数 太空。更大、更高的笼子更适合促进积极的幸福感，也是社交所必需的 收容10公斤以上的成年雄性。艺术研究往往持续很长时间，导致动物经常超过10只 体重为1000公斤，因此需要更大尺寸的笼子。此外，正在申请的笼子有 已针对ART的易管理性进行了优化。前面有一个扩大的开口，可以让 技术人员更轻松、更安全地为动物注射，挤压机构也得到了改进， 与老式笼子相比，可在此过程中提供更好的约束。这些笼子也被 设计用于更好地方便用于采血的程序笼子的连接。在 ONPRC目前有115只猕猴被分配到需要抗逆转录病毒治疗的艾滋病相关研究中。基于当前 据预测，需要抗逆转录病毒治疗的国家卫生计划的艾滋病毒/艾滋病作业可能在明年增加到250项。 ONPRC非常需要为我们的NHP研究领域提供新的、最新的笼子。这个新的笼子将会 通过提供适合猕猴日常需求的大小合适的住房来支持艾滋病毒/艾滋病研究 抗逆转录病毒治疗。将购买9个一对一社交架子(总共18个笼子)放在 传染病研究适宜动物拘留室。