SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

SPF 4 艾滋病研究恒河猴繁殖群

• 批准号: 10083095
• 负责人: Gregory Brion Timmel
• 金额: $ 36.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10083095
• 关键词: AIDS prevention; AIDS vaccine development; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animals; Biomedical Research; Breeding; Disease; Ensure; Female; Genetic Variation; Genotype; HIV; Human; Immune system; Macaca; Macaca mulatta; Modeling; Oregon; Pathogenesis; Primates; Research; Research Subjects; Resources; SIV; Target Populations; Vaccines; Viral; Work; design; genetic testing; germ free condition; pandemic disease; pathogen; programs; simian human immunodeficiency virus; testing services; vaccine development; vector vaccine

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development, as well as other approaches for controlling AIDS, are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Domestic breeding programs that are designed to efficiently produce well characterized Indian-origin rhesus macaques are necessary to ensure the supply of biomedical research subjects required for AIDS vaccine development and treatments, and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

项目摘要，总体 安全有效的疫苗仍然是控制人类免疫缺陷病毒的最佳希望 （艾滋病毒）大流行。由于印度 - 原来的恒河猕猴（Macaca Mulatta）和人类之间的相似之处 免疫系统，疫苗开发以及其他控制艾滋病的方法 取决于SIV和SHIV猕猴模型。对印度 - 原来的恒河神有持续的需求 猕猴支持这项工作。旨在有效生产良好的家庭育种计划 必须进行特征的印度 - 原来的恒河猕猴，以确保生物医学研究的供应 艾滋病疫苗发育和治疗以及发病机理研究所需的受试者。目的 该建议是为遗传表征，特定病原体的，印度 - 原始恒河神提供支持 猕猴艾滋病研究殖民地资源于2001年在俄勒冈国家灵长类动物上建立 研究中心。