SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

SPF 4 艾滋病研究恒河猴繁殖群

• 批准号: 10609283
• 负责人: Gregory Brion Timmel
• 金额: $ 10.45万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609283
• 关键词: AIDS prevention; AIDS vaccine development; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animals; Biomedical Research; Breeding; Disease; Ensure; Female; Genetic Variation; Genotype; HIV; Human; Immune system; Macaca; Macaca mulatta; Modeling; Oregon; Pathogenesis; Primates; Research; Research Subjects; Resources; SIV; Target Populations; Vaccines; Viral; Work; design; genetic testing; germ free condition; pandemic disease; pathogen; programs; simian human immunodeficiency virus; testing services; vaccine development; vector vaccine

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development, as well as other approaches for controlling AIDS, are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Domestic breeding programs that are designed to efficiently produce well characterized Indian-origin rhesus macaques are necessary to ensure the supply of biomedical research subjects required for AIDS vaccine development and treatments, and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

项目概要，总体 安全、有效的疫苗仍然是控制人类免疫缺陷病毒的最佳希望 （艾滋病毒）大流行。由于原产于印度的恒河猴（Macaca mulatta）与人类有相似之处 免疫系统、疫苗开发以及其他控制艾滋病的方法都受到严重影响 依赖于 SIV 和 SHIV 猕猴模型。对印度恒河猴的需求持续增长 猕猴来支持这项工作。旨在高效生产优质产品的国内育种计划 具有特征的印度原产恒河猴对于确保生物医学研究的供应是必要的 艾滋病疫苗开发和治疗以及发病机制研究所需的受试者。目的 该提案旨在为具有遗传特征、无特定病原体、印度产恒河猴提供支持 2001 年在俄勒冈国家灵长类动物中心建立的猕猴艾滋病研究群资源 研究中心。