SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

SPF 4 艾滋病研究恒河猴繁殖群

• 批准号: 10609283
• 负责人: Gregory Brion Timmel
• 金额: $ 10.45万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609283
• 关键词: AIDS prevention; AIDS vaccine development; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animals; Biomedical Research; Breeding; Disease; Ensure; Female; Genetic Variation; Genotype; HIV; Human; Immune system; Macaca; Macaca mulatta; Modeling; Oregon; Pathogenesis; Primates; Research; Research Subjects; Resources; SIV; Target Populations; Vaccines; Viral; Work; design; genetic testing; germ free condition; pandemic disease; pathogen; programs; simian human immunodeficiency virus; testing services; vaccine development; vector vaccine

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development, as well as other approaches for controlling AIDS, are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Domestic breeding programs that are designed to efficiently produce well characterized Indian-origin rhesus macaques are necessary to ensure the supply of biomedical research subjects required for AIDS vaccine development and treatments, and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.

项目概要，总体 安全、有效的疫苗仍然是控制人体免疫缺陷病毒的最大希望 (HIV)流行病由于印度恒河猴（Macaca mulatta）和人类之间的相似性， 免疫系统、疫苗开发以及其他控制艾滋病的方法， 依赖于SIV和SHIV猕猴模型。对印度恒河猴的持续需求 猕猴来支持这项工作。国内育种计划，旨在有效地生产良好的 有特征的印度恒河猴是确保生物医学研究供应所必需的 艾滋病疫苗开发和治疗以及发病机制研究所需的受试者。的目的 这项建议是为具有遗传特征的、无特定病原体的、印度原产的恒河猴提供支持 2001年在俄勒冈州国家灵长类动物中心建立的猕猴艾滋病研究群体资源 研究中心