Diagnostic signatures of Zika virus pathogenesis

寨卡病毒发病机制的诊断特征

• 批准号: 9298458
• 负责人: Catherine A Blish
• 金额: $ 21.98万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-21 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298458
• 关键词: Acute; Aedes; Affect; Americas; Amniotic Fluid; Area; Automobile Driving; Brain; Brazil; Child; Cohort Studies; Congenital Abnormality; Culicidae; Dengue Virus; Detection; Diagnostic; Diagnostic tests; Enrollment; Epidemic; Fetus; Gene Expression Profile; Genetic Transcription; Health; Human; Immune response; Infection; Inflammatory; Inflammatory Response; Influenza; Latin America; Microcephaly; Mothers; Neurological outcome; Notification; Outcome; Pathogenesis; Pathology; Pathway interactions; Placenta; Pregnancy; Pregnant Women; Premature Birth; Prospective Studies; Prospective cohort; Public Health; Risk; Seasons; Structure; Therapeutic; Viral; Viremia; Virus; Virus Diseases; Whole Blood; Woman; Zika Virus; adverse pregnancy outcome; base; combat; experience; fetal; fetal infection; global health; improved; malformation; novel diagnostics; novel therapeutic intervention; placental infection; predictive signature; predictive tools; pregnant; prognostic; response; stillbirth; tool; transmission process; vector; virus pathogenesis

ABSTRACT As the Zika virus (ZIKV) epidemic sweeps through the Americas, the risks to public health are tremendous. Although prospective studies are limited, microcephaly and other major fetal abnormalities may occur in up to 30% of children born to ZIKV-infected mothers. There is a pressing need for new diagnostic, prognostic, and therapeutic tools to combat this global health threat. We propose that the maternal immune response may provide a window into understanding the pathogenesis of ZIKV during pregnancy. We therefore aim to define the transcriptional signatures of the immune response to ZIKV during pregnancy and to identify signatures predictive of adverse fetal outcomes. Defining these signatures could have a significant impact on the management of pregnant women exposed to ZIKV by serving as a basis for improved diagnostic tests for detecting ZIKV, therapeutic approaches targeting identified pathways, and an improved ability to predict fetal risk.

摘要 随着寨卡病毒(ZIKV)疫情席卷美洲，公共卫生面临的风险是巨大的。 尽管前瞻性研究有限，但小头畸形和其他主要胎儿畸形可能发生在 感染寨卡病毒的母亲所生的孩子中有30%。迫切需要新的诊断、预后和 治疗工具，以对抗这一全球健康威胁。我们认为母体免疫反应可能 为了解ZIKV在妊娠期的发病机制提供了一个窗口。因此，我们的目标是定义 孕期寨卡病毒免疫应答的转录特征及其识别特征 预示着不良的胎儿结局。定义这些签名可能会对 对暴露于寨卡病毒的孕妇进行管理，作为改进诊断试验的基础 检测ZIKV，针对已识别路径的治疗方法，以及改进的预测胎儿的能力 风险。