Multimodal Neuroimaging of Stress, Arousal and Alcoholism Risk

压力、觉醒和酗酒风险的多模式神经影像学

• 批准号: 9256397
• 负责人: DONGJU SEO
• 金额: $ 19.51万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9256397
• 关键词: Alcohol abuse; Alcohol consumption; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Area; Arousal; Autonomic nervous system; Award; Behavior; Brain; Chronic; Cities; Clinical; Clinical Investigator; Clinical Psychology; Clinical Research; Data; Data Collection; Doctor of Medicine; Doctor of Philosophy; Emotional; Emotions; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Grant; Heart Rate; Heavy Drinking; Hyperactive behavior; Intake; International; Learning; Light; Longitudinal Studies; Measures; Mentors; Minnesota; Monitor; Motivation; Neurosciences; Neurosciences Research; Outcome; Pattern; Physiological; Pilot Projects; Postdoctoral Fellow; Prefrontal Cortex; Prevention strategy; Psychiatry; Public Health; Regulation; Research; Research Design; Research Methodology; Research Personnel; Resources; Rest; Rewards; Risk; Role; Sampling; Scientist; Sex Characteristics; Stress; Study Skills; System; Techniques; Technology; Testing; Training; Training Programs; Training Support; Translational Research; Twin Multiple Birth; Universities; Visual; Voice; Woman; addiction; alcohol craving; alcohol cue; alcohol measurement; alcohol research; alcohol risk; alcohol use disorder; base; binge drinking; career; craving; design; disorder risk; drinking; drinking behavior; follow-up; heart rate variability; high risk; high risk drinking; men; multimodality; neurodevelopment; neuroimaging; neuromechanism; novel; post-doctoral training; programs; prospective; public health relevance; relating to nervous system; response; skills; social; training opportunity; translational neuroscience; treatment strategy; visual stimulus

DESCRIPTION (provided by applicant): Dr. Dongju Seo is an associate research scientist in the Department of Psychiatry at Yale University specializing in functional magnetic resonance imaging (fMRI). Dr. Seo received a Ph.D. in Clinical Psychology from the University of Minnesota, Twin Cities in 2008 and subsequently completed postdoctoral training at Yale University with a focus on stress and addiction. The long-term goal of the candidate is to develop an interdisciplinary program of research to competitively conduct and interpret translational neuroscience research on alcoholism using multimodal neuroimaging and connectivity mapping. Specifically, her research focuses on stress- and autonomic nervous system (ANS)- related neural dysregulation associated with heavy alcohol use, discovering vulnerability markers for alcoholism risk, and developing effective prevention and treatment strategies. Her short-term goal is to obtain the skills and resources required to achieve her long-term goals and to become an independent researcher through the training and support provided by this K08 Award. Her preliminary findings indicate that binge and heavy alcohol use is influenced by a functional disconnectivity between the VmPFC regulatory system and the ANS arousal regions, brain areas involved in the modulation of emotions and rewarding states. Based on this result, it is hypothesized that decreased functional connectivity in the VmPFC-ANS circuit contributes to emotional and ANS disruption and alcohol intake in heavy social drinkers. The candidate aims to test this hypothesis in a larger sample and seeks support to learn new skills for this study. Her research strategy will be to examine brain and ANS response in heavy and light social drinkers using simultaneous fMRI and ANS recording, functional connectivity mapping, and combined clinical design to identify neural measures associated with risk for alcohol abuse. Her training program will cover the following topics relating to the interdisciplinary neuroscience of alcoholism: 1) learning fMRI connectivity mapping and translational neuroscience of alcoholism 2) combining fMRI and ANS techniques and analysis, and 3) developing expertise in longitudinal study design and analysis for alcohol research. Her mentors include internationally prominent experts in translational research on alcoholism (Rajita Sinha, Ph.D.; John H. Krystal, M.D.), multimodal neuroimaging and connectivity mapping (Todd Constable, Ph.D.) and longitudinal research on alcoholism (Howard Tennen, Ph.D.; Ralitza Gueorguieva, Ph.D.). The K08 Award will allow the candidate to acquire new skills and resources to test the hypothesis and provide Dr. Seo with a valuable opportunity to grow into an independent clinical investigator, with expertise in the application of state-of-the art, multimoda neuroimaging techniques to conduct translational neuroscience research on alcoholism.

描述（由申请人提供）：Dongju SEO博士是耶鲁大学精神病学系的副研究科学家，专门研究功能磁共振成像（fMRI）。 SEO博士获得博士学位明尼苏达大学的临床心理学博士学位，2008年双城，随后在耶鲁大学完成了博士后培训，重点是压力和成瘾。候选人的长期目标是制定跨学科研究计划，以使用多模式神经影像和连通性映射来竞争性地进行和解释酒精中毒的转化神经科学研究。具体而言，她的研究重点是压力和自主神经系统（ANS） - 与大量饮酒有关的相关神经失调，发现酒精中毒风险的脆弱性标志物以及制定有效的预防和治疗策略。她的短期目标是获得实现长期目标所需的技能和资源，并通过本K08奖提供的培训和支持成为独立的研究人员。她的初步发现表明，暴饮暴食和大量饮酒受到VMPFC调节系统与ANS唤醒区域的功能脱节性的影响。基于此结果，假设VMPFC-ANS电路中功能连通性的降低有助于激烈的社交饮酒者的情绪和ANS的破坏和酒精摄入。候选人旨在在更大的样本中检验这一假设，并寻求支持以学习这项研究的新技能。她的研究策略将是使用同时fMRI和ANS记录，功能连接映射以及合并的临床设计来检查重和轻饮者中的大脑和ANS反应，以识别与酒精滥用风险相关的神经测量。她的培训计划将涵盖与酒精中毒的跨学科神经科学有关的以下主题：1）学习fMRI连通性映射和酒精中毒的转化神经科学2）将fMRI和ANS技术和分析结合在一起，以及3）研究纵向研究和分析酒精研究的专业知识。她的导师包括酗酒转化研究的国际知名专家（Rajita Sinha，Ph.D。; John H. Krystal，M.D。），多模式的神经影像学和连通性映射（Todd Constable，Ph.D。）和酒精中毒的纵向研究（Howard Tennen，Ph.d。howard tennen，Ph.d。; Ralitza gueorguiev a。 K08奖将使候选人能够获取新的技能和资源来检验假设，并为SEO博士提供宝贵的机会，使其成为独立的临床研究者，并在采用最先进的Multimoda神经影像学技术方面具有专业知识，以进行转化神经科学研究。