Multimodal Neuroimaging of Stress, Arousal and Alcoholism Risk

压力、觉醒和酗酒风险的多模式神经影像学

• 批准号: 9256397
• 负责人: DONGJU SEO
• 金额: $ 19.51万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9256397
• 关键词: Alcohol abuse; Alcohol consumption; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Area; Arousal; Autonomic nervous system; Award; Behavior; Brain; Chronic; Cities; Clinical; Clinical Investigator; Clinical Psychology; Clinical Research; Data; Data Collection; Doctor of Medicine; Doctor of Philosophy; Emotional; Emotions; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Grant; Heart Rate; Heavy Drinking; Hyperactive behavior; Intake; International; Learning; Light; Longitudinal Studies; Measures; Mentors; Minnesota; Monitor; Motivation; Neurosciences; Neurosciences Research; Outcome; Pattern; Physiological; Pilot Projects; Postdoctoral Fellow; Prefrontal Cortex; Prevention strategy; Psychiatry; Public Health; Regulation; Research; Research Design; Research Methodology; Research Personnel; Resources; Rest; Rewards; Risk; Role; Sampling; Scientist; Sex Characteristics; Stress; Study Skills; System; Techniques; Technology; Testing; Training; Training Programs; Training Support; Translational Research; Twin Multiple Birth; Universities; Visual; Voice; Woman; addiction; alcohol craving; alcohol cue; alcohol measurement; alcohol research; alcohol risk; alcohol use disorder; base; binge drinking; career; craving; design; disorder risk; drinking; drinking behavior; follow-up; heart rate variability; high risk; high risk drinking; men; multimodality; neurodevelopment; neuroimaging; neuromechanism; novel; post-doctoral training; programs; prospective; public health relevance; relating to nervous system; response; skills; social; training opportunity; translational neuroscience; treatment strategy; visual stimulus

DESCRIPTION (provided by applicant): Dr. Dongju Seo is an associate research scientist in the Department of Psychiatry at Yale University specializing in functional magnetic resonance imaging (fMRI). Dr. Seo received a Ph.D. in Clinical Psychology from the University of Minnesota, Twin Cities in 2008 and subsequently completed postdoctoral training at Yale University with a focus on stress and addiction. The long-term goal of the candidate is to develop an interdisciplinary program of research to competitively conduct and interpret translational neuroscience research on alcoholism using multimodal neuroimaging and connectivity mapping. Specifically, her research focuses on stress- and autonomic nervous system (ANS)- related neural dysregulation associated with heavy alcohol use, discovering vulnerability markers for alcoholism risk, and developing effective prevention and treatment strategies. Her short-term goal is to obtain the skills and resources required to achieve her long-term goals and to become an independent researcher through the training and support provided by this K08 Award. Her preliminary findings indicate that binge and heavy alcohol use is influenced by a functional disconnectivity between the VmPFC regulatory system and the ANS arousal regions, brain areas involved in the modulation of emotions and rewarding states. Based on this result, it is hypothesized that decreased functional connectivity in the VmPFC-ANS circuit contributes to emotional and ANS disruption and alcohol intake in heavy social drinkers. The candidate aims to test this hypothesis in a larger sample and seeks support to learn new skills for this study. Her research strategy will be to examine brain and ANS response in heavy and light social drinkers using simultaneous fMRI and ANS recording, functional connectivity mapping, and combined clinical design to identify neural measures associated with risk for alcohol abuse. Her training program will cover the following topics relating to the interdisciplinary neuroscience of alcoholism: 1) learning fMRI connectivity mapping and translational neuroscience of alcoholism 2) combining fMRI and ANS techniques and analysis, and 3) developing expertise in longitudinal study design and analysis for alcohol research. Her mentors include internationally prominent experts in translational research on alcoholism (Rajita Sinha, Ph.D.; John H. Krystal, M.D.), multimodal neuroimaging and connectivity mapping (Todd Constable, Ph.D.) and longitudinal research on alcoholism (Howard Tennen, Ph.D.; Ralitza Gueorguieva, Ph.D.). The K08 Award will allow the candidate to acquire new skills and resources to test the hypothesis and provide Dr. Seo with a valuable opportunity to grow into an independent clinical investigator, with expertise in the application of state-of-the art, multimoda neuroimaging techniques to conduct translational neuroscience research on alcoholism.

描述（由申请人提供）：Dongju Seo博士是耶鲁大学精神病学系的副研究员，专门从事功能性磁共振成像（fMRI）。徐博士获得博士学位。2008年，他从明尼苏达大学双城分校获得临床心理学博士学位，随后在耶鲁大学完成了博士后培训，重点是压力和成瘾。候选人的长期目标是开发一个跨学科的研究计划，使用多模态神经成像和连接映射竞争性地进行和解释关于酒精中毒的转化神经科学研究。具体来说，她的研究重点是与大量饮酒相关的压力和自主神经系统（ANS）相关的神经失调，发现酗酒风险的脆弱性标志物，并制定有效的预防和治疗策略。她的短期目标是获得实现长期目标所需的技能和资源，并通过K 08奖提供的培训和支持成为一名独立研究人员。她的初步研究结果表明，酗酒和酗酒受到VmPFC调节系统和ANS唤醒区域之间功能性断开的影响，这些区域参与情绪和奖励状态的调节。基于这一结果，假设VmPFC-ANS回路中的功能连接性降低有助于重度社交饮酒者的情绪和ANS破坏以及酒精摄入。候选人的目标是在更大的样本中测试这一假设，并寻求支持，以学习本研究的新技能。她的研究策略将是检查大脑和ANS反应在重度和轻度社会饮酒者使用同时功能磁共振成像和ANS记录，功能连接映射，并结合临床设计，以确定与酒精滥用风险相关的神经措施。她的培训计划将涵盖与酒精中毒的跨学科神经科学相关的以下主题：1）学习fMRI连接映射和酒精中毒的转化神经科学2）结合fMRI和ANS技术和分析，以及3）开发纵向研究设计和分析酒精研究的专业知识。她的导师包括国际知名的酗酒转化研究专家（Rajita Sinha，博士; John H. Krystal，医学博士），多模态神经成像和连接映射（托德康斯特布尔，博士）和纵向研究酗酒（霍华德Tennen，博士; Ralitza Gueorguieva，Ph.D.）。K 08奖将使候选人获得新的技能和资源来测试假设，并为徐博士提供一个宝贵的机会，使其成长为一名独立的临床研究者，并具有应用最先进的多模态神经成像技术进行酒精中毒转化神经科学研究的专业知识。