Optomechanical Characteristics of Lens Accommodation

项目摘要 根据PA-16-242（生物工程）提交的本延续项目的目标 研究赠款），是研究老视的机制，与年龄有关的渐进性损失， 近距离看得清楚的能力。长期目标是使发展 有效的策略，以恢复在老花眼的住宿。 该项目解决了在该领域取得进展的两个关键障碍： 了解导致老花眼的因素，特别是睫状肌的作用 和B）需要能够客观评估程序结果的技术， 在临床环境中恢复调节。 该项目有两个具体目标： 目的1：开发一种高速集成的多通道调节生物测量系统 住宿生物统计系统将建立在第一代系统的基础上， 项目前期开发。该系统将结合联合收割机动态自动验光仪和 在集成的硬件和软件平台中的两个光学相干断层扫描系统 这将使得能够在临床环境中由单个用户获取数据。它将使高速 并且精确同步测量睫状肌运动的动力学， 晶体透镜的形状变化，以及响应于脉冲阶跃的折射变化 和调节的斜坡刺激。 目的2：研究睫状肌的动力学特性与调节和年龄的关系 调节生物测量系统将用于量化睫状肌的动力学 以及年龄在14岁到18岁之间的参与者的晶体透镜形状的结果变化。 74岁，白内障手术患者，将在术前和术后1个月进行成像 人工晶状体植入后。数据将被分析，以测试预测，a）有年龄- 年龄中睫状肌动力学及其与透镜相互作用的相关变化 导致老花眼的范围; B）老花眼与睫状肌的改变有关 可能影响恢复调节能力的形态学;和c）替代 具有人工植入物的天然透镜改变了睫状肌对晶状体刺激的反应能力， 调节刺激。 该项目将对老视研究领域产生广泛影响。它将产生新的 实时成像眼睛的睫状肌及其与透镜的相互作用的技术 住宿期间。它还将产生关于老花眼原因的新知识， 将为新程序的开发和优化提供良好的生理基础 以及旨在恢复调节的植入物。

PROJECT SUMMARY The objective of this continuation project, submitted in response to PA-16-242 (Bioengineering Research Grants), is to study the mechanism of presbyopia, the progressive age-related loss of the ability to see clearly at near distances. The long-term goal is to enable the development of effective strategies to restore accommodation in presbyopes. The project addresses two critical barriers to progress in the field: a) the need for a better understanding of the factors contributing to presbyopia, particularly the role of the ciliary muscle and b) the need for technologies that can objectively assess the outcomes of procedures to restore accommodation in a clinical setting. The project has two specific aims: Aim 1: To develop a high speed integrated multimodal accommodation biometry system The accommodation biometry system will build on a first generation of the system that was developed in the previous project period. The system will combine a dynamic autorefractor and two optical coherence tomography systems in an integrated hardware and software platform that will enable acquisition of data by a single user in a clinical setting. It will enable high-speed and precisely synchronized measurements of the dynamics of ciliary muscle movement, changes in shape of the crystalline lens, and changes in refraction in response to pulse-step and ramp stimuli of accommodation. Aim 2: To characterize the dynamics of the ciliary muscle with accommodation and age The accommodation biometry system will be used to quantify the dynamics of the ciliary muscle and the resulting changes in crystalline lens shape in participants with ages ranging from 14 to 74 years and in cataract surgery patients who will be imaged pre-operatively and one month after IOL implantation. The data will be analyzed to test the predictions that a) there are age- related changes in the dynamics of the ciliary muscle and its interaction with the lens in the age range leading to presbyopia; b) presbyopia is associated with alterations in the ciliary muscle morphology that may affect the ability to restore accommodation; and c) replacement of the natural lens with an artificial implant alters the ability of the ciliary muscle to respond to an accommodation stimulus. The project will have a broad impact on the field of presbyopia research. It will produce new technology to image the ciliary muscle of the eye and its interaction with the lens in real-time during accommodation. It will also generate new knowledge on the causes of presbyopia that will form a sound physiological basis for the development and optimization of new procedures and implants designed to restore accommodation.