Optomechanical Characteristics of Lens Accommodation

项目总结 本延续项目的目标，根据PA-16-242(生物工程)提交 研究基金)，是为了研究老花眼的机制，进行性年龄相关的损失 近距离看得很清楚的能力。我们的长期目标是使 有效的策略，以恢复老人的住宿。 该项目解决了在实地取得进展的两个关键障碍：a)需要更好的 了解导致老花眼的因素，特别是睫状肌的作用 和b)需要能够客观评估程序结果的技术 恢复临床环境中的适应能力。 该项目有两个具体目标： 目标1：开发一种高速集成多通道住宿生物测量系统 住宿生物测定系统将建立在第一代系统的基础上，该系统 在前一个项目期内开发的。该系统将结合动态自动屈光仪和 硬件和软件集成平台上的两个光学相干层析成像系统 这将使单个用户能够在临床环境中获取数据。它将使高速 以及对睫状肌运动动力学的精确同步测量， 晶体形状的变化，以及对脉冲阶跃响应的折射的变化 以及调节的坡道刺激。 目的2：描述睫状肌的动态变化与调节和年龄的关系 调节生物测量系统将被用来量化睫状肌的动力学 以及由此导致的14岁至14岁参与者晶状体形状的变化 74岁和白内障手术患者将在手术前和一个月内进行成像 人工晶状体植入术后。将对数据进行分析，以检验以下预测：a)存在年龄- 年龄与睫状肌动力学及其与晶状体相互作用的相关变化 导致老花眼；b)老花眼与睫状肌的改变有关 可能影响恢复调节能力的形态；以及c)替换 带有人工植入物的天然晶状体改变了睫状肌对 通融刺激。 该项目将对老花眼研究领域产生广泛影响。它将产生新的 实时成像眼睛睫状肌及其与晶状体的相互作用的技术 在住宿期间。它还将产生关于老花眼病因的新知识， 将为新程序的开发和优化奠定良好的生理基础 以及为恢复住宿而设计的植入物。

PROJECT SUMMARY The objective of this continuation project, submitted in response to PA-16-242 (Bioengineering Research Grants), is to study the mechanism of presbyopia, the progressive age-related loss of the ability to see clearly at near distances. The long-term goal is to enable the development of effective strategies to restore accommodation in presbyopes. The project addresses two critical barriers to progress in the field: a) the need for a better understanding of the factors contributing to presbyopia, particularly the role of the ciliary muscle and b) the need for technologies that can objectively assess the outcomes of procedures to restore accommodation in a clinical setting. The project has two specific aims: Aim 1: To develop a high speed integrated multimodal accommodation biometry system The accommodation biometry system will build on a first generation of the system that was developed in the previous project period. The system will combine a dynamic autorefractor and two optical coherence tomography systems in an integrated hardware and software platform that will enable acquisition of data by a single user in a clinical setting. It will enable high-speed and precisely synchronized measurements of the dynamics of ciliary muscle movement, changes in shape of the crystalline lens, and changes in refraction in response to pulse-step and ramp stimuli of accommodation. Aim 2: To characterize the dynamics of the ciliary muscle with accommodation and age The accommodation biometry system will be used to quantify the dynamics of the ciliary muscle and the resulting changes in crystalline lens shape in participants with ages ranging from 14 to 74 years and in cataract surgery patients who will be imaged pre-operatively and one month after IOL implantation. The data will be analyzed to test the predictions that a) there are age- related changes in the dynamics of the ciliary muscle and its interaction with the lens in the age range leading to presbyopia; b) presbyopia is associated with alterations in the ciliary muscle morphology that may affect the ability to restore accommodation; and c) replacement of the natural lens with an artificial implant alters the ability of the ciliary muscle to respond to an accommodation stimulus. The project will have a broad impact on the field of presbyopia research. It will produce new technology to image the ciliary muscle of the eye and its interaction with the lens in real-time during accommodation. It will also generate new knowledge on the causes of presbyopia that will form a sound physiological basis for the development and optimization of new procedures and implants designed to restore accommodation.