High Sensitivity Flow Imaging of the Human Placenta with Coherence-Based Doppler Ultrasound

使用相干多普勒超声对人胎盘进行高灵敏度血流成像

• 批准号: 9270591
• 负责人: Jeremy Dahl
• 金额: $ 44.89万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-17 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270591
• 关键词: Acoustics; Angiography; Animals; Arteries; Blood; Blood Vessels; Blood flow; Caliber; Clinical; Clinical Research; Cues; Data; Detection; Development; Diagnostic; Discipline of obstetrics; Disease; Doppler Ultrasound; Fetal Growth Retardation; Fetus; Gadolinium; Gases; Growth; Human; Image; Imagery; Imaging technology; Lead; Link; Magnetic Resonance Imaging; Methodology; Methods; Monitor; Motion; Noise; Normal Range; Nutrient; Organ; Phase; Physiologic pulse; Physiological; Pilot Projects; Placenta; Placenta Accreta; Placenta Diseases; Placentation; Play; Pre-Eclampsia; Pregnancy; Pregnancy loss; Pregnant Women; Process; Radioisotopes; Radionuclide Imaging; Real-Time Systems; Request for Applications; Research Personnel; Resolution; Roentgen Rays; Role; Spiral Artery of the Endometrium; Structure; System; Techniques; Technology; Testing; Time; Tissues; Translating; Trees; Ultrasonics; Ultrasonography; Villous; X-Ray Computed Tomography; animal imaging; base; clinically relevant; cohort; cost; delivery complications; early onset; fetal; human imaging; imaging capabilities; imaging modality; imaging system; improved; in vivo; innovation; novel; programs; public health relevance; response; simulation; success; tool; uptake; wasting

 DESCRIPTION (provided by applicant): The placenta is a key organ during pregnancy that is rich in blood vessels, which facilitate nutrient uptake, waste elimination, and gas exchange. Due to the presence of the developing fetus and the fact that human placenta is very different from nearly all other animal placenta, many of the current imaging technologies that would provide the necessary resolution to visualize human placenta structure and function cannot be utilized in vivo. Ultrasound imaging is nearly alone in its capability to safely image human placenta; however current ultrasound imaging technology cannot adequately visualize the vessels supplying and traversing this organ during its developmental phase. Novel tools to visualize and study the vascular network would be useful for understanding normal and abnormal placental development, including common placenta disorders such as preeclampsia and intrauterine growth restriction. In this application, we propose to develop a new ultrasonic imaging method for flow detection, called Coherent Flow Power Doppler (CFPD) that greatly enhances the ability to visualize small vessels with slow blood flow. We present preliminary data demonstrating the success of this technique in simulations, phantoms, and off-line in vivo data. We also propose to build this imaging system onto a clinical scanner, for high-quality real-time imaging of the in viv placenta. We propose to analyze the real-time CFPD imaging system in a clinical study involving the maternal spiral arteries, which are key vessels in the placenta development process and are linked to placental disorders such as preeclampsia and intrauterine growth restriction.

 描述（申请人提供）：胎盘是怀孕期间的关键器官，血管丰富，有利于营养吸收、废物排除和气体交换。由于发育中胎儿的存在以及人类胎盘与几乎所有其他动物胎盘非常不同的事实，目前许多能够提供必要分辨率来可视化人类胎盘结构和功能的成像技术无法在体内使用。超声波成像几乎是唯一能够安全地对人类胎盘进行成像的技术。然而，当前的超声成像技术无法充分可视化在发育阶段供应和穿过该器官的血管。可视化和研究血管网络的新工具将有助于了解正常和异常胎盘发育，包括常见的胎盘疾病，如先兆子痫和宫内生长受限。在此应用中，我们建议开发一种新的用于血流检测的超声成像方法，称为相干流动功率多普勒（CFPD），它大大增强了血流缓慢的小血管的可视化能力。我们提供的初步数据证明了该技术在模拟、体模和离线体内数据方面的成功。我们还建议将该成像系统构建到临床扫描仪上，以对体内胎盘进行高质量实时成像。我们建议在一项涉及母体螺旋动脉的临床研究中分析实时 CFPD 成像系统，母体螺旋动脉是胎盘发育过程中的关键血管，与先兆子痫和宫内生长受限等胎盘疾病有关。