Clinical Trials Network: The Texas Node

 描述：这是一个竞争性的续期申请，以继续资助NIDA临床试验网络（CTN）的德克萨斯节点（TxN）。在上一个资助期间，位于达拉斯的德克萨斯大学西南医学中心的TxN为CTN研究、科学文献、传播和培训活动做出了重大贡献，TxN研究中心在实施的8项CTN试验中表现最佳。TxN的科学家开发并领导了三项研究：第一项大型研究，评估运动作为兴奋剂使用的新干预措施，遗传学研究和使用电子健康记录（EHR）的研究。对该领域作出了杰出贡献，出版了38份出版物，作了57次专题介绍。通过TxN主办的年度讲习班，300多名戒毒治疗提供者接受了若干循证做法方面的培训。科学家指导初级研究人员，从而获得资助和出版物。在上一个供资期内为提高效率、减少支出和不断提高性能而进行的更改为TxN在下一个供资期内的出色表现做好了独特的准备。此更新申请利用了PI Madhukar H 20多年的经验。Trivedi，MD，和其他主要研究人员的经验，通过其对初级保健网络，大型护理系统的重视，以及使用EHR对物质使用产生积极影响。在TxN与专业成瘾社区治疗计划合作的坚实基础上，与医疗保健网络建立了更多的合作伙伴关系，为德克萨斯州和美国各地的不同患者群体提供服务。这些网络很高兴与TxN和CTN合作。合作伙伴包括美国最大的青少年门诊初级保健网络之一，美国最大的安全网医院系统之一，以及美国家庭医生学会国家研究网络。其他重要的合作团体包括国家VA物质使用障碍-质量增强研究计划，以患者为中心的结果研究所的大平原合作，以及国家推进转化科学中心临床试验累积。TxN研究议程侧重于早期识别和干预，与CTN的优先事项一致，解决了节点合作伙伴确定的临床需求，并利用了TxN的专业知识。TxN旨在通过利用创新干预措施以及EHR和其他基于技术的方法来回答对该领域至关重要的问题，在初级保健方面，以显着改善对滥用药物者的护理。

 DESCRIPTION: This is a competing renewal application to continue funding the Texas Node (TxN) of the NIDA Clinical Trials Network (CTN). During the previous funding period the TxN, based at the University of Texas Southwestern Medical Center in Dallas, made substantial contributions to CTN research, the scientific literature, and dissemination and training activities TxN study sites were top performers across the 8 CTN trials implemented. TxN scientists developed and led three studies: the first large study to evaluate exercise as a novel intervention for stimulant use, a genetics study, and a study using electronic health records (EHRs). Outstanding contributions to the field were made, with 38 publications and 57 presentations. Over 300 addiction treatment providers were trained in several evidence-based practices via annual workshops hosted by the TxN. Scientists mentored junior investigators, resulting in funded grants and publications. Changes made to increase efficiency, decrease expenditures, and continually improve performance during the previous funding period have uniquely prepared the TxN to perform superbly during the next period. This renewal application capitalizes on over 20 years of experience of the PI, Madhukar H. Trivedi, MD, and the experiences of other key investigators through its emphasis on primary care networks, large systems of care, and use of EHRs to positively impact substance use. Building on the TxN's solid foundation of collaborating with specialty addiction community treatment programs, additional partnerships have been secured with healthcare networks that provide access to varied patient populations throughout Texas and the US. These networks are excited to work with the TxN and the CTN. Partners include one of the largest adolescent outpatient primary care networks in the US, one of the largest safety net hospital systems in the US, and the American Academy of Family Physicians National Research Network. Other important collaborating groups include the national VA Substance Use Disorder - Quality Enhancement Research Initiative, Patient Centered Outcomes Research Institute's Greater Plains Collaborative, and the National Center for Advancing Translational Sciences Accrual for Clinical Trials. The TxN research agenda, which focuses on early identification and intervention, is consistent with the CTN's priorities, addresses clinical needs identified by node partners, and capitalizes on expertise in the TxN. The TxN aims to answer questions of critical importance to the field by utilizing innovative interventions as well as EHR- and other technology-based methods, at the point of primary care, to significantly improve the care of persons who misuse substances.